Exogenous polyamines promote osteogenic differentiation by reciprocally regulating osteogenic and adipogenic gene expression

Journal of Cellular Biochemistry

Volumn 114, Issue 12, 2013, Pages 2718-2728

  Lee, Mon Juan ^a   Chen, Yuhsin ^a,b   Huang, Yuan Pin ^c   Hsu, Yi Chiang ^a   Chiang, Lan Hsin ^a   Chen, Tzu Yu ^a   Wang, Gwo Jaw ^d,e,f,g  

^a CHANG JUNG CHRISTIAN UNIVERSITY   (Taiwan)

^b FISHERIES RESEARCH INSTITUTE   (Taiwan)

^c CHENG SHIU UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^g UNIVERSITY OF VIRGINIA   (United States)

Author keywords

ADIPOGENIC DIFFERENTIATION; MESENCHYMAL STEM CELLS; OSTEOGENIC DIFFERENTIATION; POLYAMINES

Indexed keywords

ALKALINE PHOSPHATASE; COMPLEMENT FACTOR D; LIPID; MESSENGER RNA; ORNITHINE DECARBOXYLASE; OSTEOCALCIN; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYAMINE DERIVATIVE; POLYAMINE MODULATED FACTOR 1; PUTRESCINE; SPERMIDINE; SPERMIDINE SPERMINE N ACETYLTRANSFERASE; SPERMINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; CELL DENSITY; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; DOWN REGULATION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MINERALIZATION; OSTEOBLAST; POLYAMINE METABOLISM; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; UPREGULATION;

ADIPOGENIC DIFFERENTIATION; MESENCHYMAL STEM CELLS; OSTEOGENIC DIFFERENTIATION; POLYAMINES;

ADIPOGENESIS; ALKALINE PHOSPHATASE; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; PUTRESCINE; SPERMIDINE; SPERMINE;

EID: 84885591157     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24620     Document Type: Article

References (36)

1. Babal P, Manuel SM, Olson JW, Gillespie MN,. 2000. Cellular disposition of transported polyamines in hypoxic rat lung and pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 278: L610-L617.
2. Chen HT, Lee MJ, Chen CH, Chuang SC, Chang LF, Ho ML, Hung SH, Fu YC, Wang YH, Wang HI, Wang GJ, Kang L, Chang JK,. 2012. Proliferation and differentiation potential of human adipose-derived mesenchymal stem cells isolated from elderly patients with osteoporotic fractures. J Cell Mol Med 16: 582-593.
3. Curran JM, Chen R, Hunt JA,. 2005. Controlling the phenotype and function of mesenchymal stem cells in vitro by adhesion to silane-modified clean glass surfaces. Biomaterials 26: 7057-7067.
4. Dredge K, Kink JA, Johnson RM, Bytheway I, Marton LJ,. 2009. The polyamine analog PG11047 potentiates the antitumor activity of cisplatin and bevacizumab in preclinical models of lung and prostate cancer. Cancer Chemother Pharmacol 65: 191-195.
5. Facchini A, Borzi RM, Olivotto E, Platano D, Pagani S, Cetrullo S, Flamigni F,. 2012. Role of polyamines in hypertrophy and terminal differentiation of osteoarthritic chondrocytes. Amino Acids 42: 667-678.
6. Gimble JM, Nuttall ME,. 2012. The relationship between adipose tissue and bone metabolism. Clin Biochem 45: 874-879.
7. Heby O,. 1981. Role of polyamines in the control of cell proliferation and differentiation. Differentiation 19: 1-20.
8. Huang Y, Keen JC, Pledgie A, Marton LJ, Zhu T, Sukumar S, Park BH, Blair B, Brenner K, Casero RA, Jr., Davidson NE,. 2006. Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells. J Biol Chem 281: 19055-19063.
9. Huang S, Wang S, Bian C, Yang Z, Zhou H, Zeng Y, Li H, Han Q, Zhao RC,. 2012. Upregulation of miR-22 promotes osteogenic differentiation and inhibits adipogenic differentiation of human adipose tissue-derived mesenchymal stem cells by repressing HDAC6 protein expression. Stem Cells Dev 21: 2531-2540.
10. Ishii I, Ikeguchi Y, Mano H, Wada M, Pegg AE, Shirahata A,. 2012. Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids 42: 619-626.
11. Kuijpers G, Schneider B, Stadel B, Colman E,. 2002. Recombinant human parathyroid hormone. Preclinical data on rat osteosarcoma were not dismissed. BMJ 324: 1218; author reply 1218.
12. Kumar AP, Butler AP,. 1997. Transcription factor Sp3 antagonizes activation of the ornithine decarboxylase promoter by Sp1. Nucleic Acids Res 25: 2012-2019.
13. Kurian L, Palanimurugan R, Godderz D, Dohmen RJ,. 2011. Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA. Nature 477: 490-494.
14. Lee NK, Skinner JP, Zajac JD, MacLean HE,. 2011. Ornithine decarboxylase is upregulated by the androgen receptor in skeletal muscle and regulates myoblast proliferation. Am J Physiol Endocrinol Metab 301: E172-E179.
15. Livak KJ, Schmittgen TD,. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25: 402-408.
16. Lopez-Garcia C, Lopez-Contreras AJ, Cremades A, Castells MT, Marin F, Schreiber F, Penafiel R,. 2008. Molecular and morphological changes in placenta and embryo development associated with the inhibition of polyamine synthesis during midpregnancy in mice. Endocrinology 149: 5012-5023.
17. Lux GD, Marton LJ, Baylin SB,. 1980. Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats. Science 210: 195-198.
18. Matsui-Yuasa I, Otani S, Morisawa S, Takigawa M, Enomoto M, Suzuki F,. 1985. Induction of spermidine/spermine N1-acetyltransferase by parathyroid hormone in rabbit costal chondrocytes in culture. J Biochem 97: 387-390.
19. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH,. 2001. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344: 1434-1441.
20. Nemoto T, Hori H, Yoshimoto M, Seyama Y, Kubota S,. 2002. Overexpression of ornithine decarboxylase enhances endothelial proliferation by suppressing endostatin expression. Blood 99: 1478-1481.
21. Palanimurugan R, Scheel H, Hofmann K, Dohmen RJ,. 2004. Polyamines regulate their synthesis by inducing expression and blocking degradation of ODC antizyme. EMBO J 23: 4857-4867.
22. Pendeville H, Carpino N, Marine JC, Takahashi Y, Muller M, Martial JA, Cleveland JL,. 2001. The ornithine decarboxylase gene is essential for cell survival during early murine development. Mol Cell Biol 21: 6549-6558.
23. Pignatti C, Tantini B, Stefanelli C, Flamigni F,. 2004. Signal transduction pathways linking polyamines to apoptosis. Amino Acids 27: 359-365.
24. Poulin R, Soulet D, Gagnon B, Rivest S, Audette M,. 2006. Evidence for a multistep model for eukaryotic polyamine transport. In:, Wang JY, Casero RA, editors. Polyamine cell signaling: Physiology, pharmacology, and cancer research. Totowa, NJ: Humana Press, Inc. pp 415-432.
25. Ramot Y, Tiede S, Biro T, Abu Bakar MH, Sugawara K, Philpott MP, Harrison W, Pietila M, Paus R,. 2011. Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PLoS ONE 6: e22564.
26. Sasaki T, Matsuoka H, Saito M,. 2008. Generation of a multi-layer muscle fiber sheet from mouse ES cells by the spermine action at specific timing and concentration. Differentiation 76: 1023-1030.
27. Shirahata A, Takahashi N, Beppu T, Hosoda H, Samejima K,. 1993. Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues. Biochem Pharmacol 45: 1897-1903.
28. Tjabringa GS, Vezeridis PS, Zandieh-Doulabi B, Helder MN, Wuisman PI, Klein-Nulend J,. 2006. Polyamines modulate nitric oxide production and COX-2 gene expression in response to mechanical loading in human adipose tissue-derived mesenchymal stem cells. Stem Cells 24: 2262-2269.
29. Tjabringa GS, Zandieh-Doulabi B, Helder MN, Knippenberg M, Wuisman PI, Klein-Nulend J,. 2008. The polymine spermine regulates osteogenic differentiation in adipose stem cells. J Cell Mol Med 12: 1710-1717.
30. Trotter J,. 2000. WinMDI 2.8 software. Windows multiple document interface flow cytometry application.
31. Vittur F, Lunazzi G, Moro L, Stagni N, de Bernard B, Moretti M, Stanta G, Bacciottini F, Orlandini G, Reali N, Casti A,. 1986. A possible role for polyamines in cartilage in the mechanism of calcification. Biochim Biophys Acta 881: 38-45.
32. Vuohelainen S, Pirinen E, Cerrada-Gimenez M, Keinanen TA, Uimari A, Pietila M, Khomutov AR, Janne J, Alhonen L,. 2010. Spermidine is indispensable in differentiation of 3T3-L1 fibroblasts to adipocytes. J Cell Mol Med 14: 1683-1692.
33. Wang Y, Devereux W, Stewart TM, Casero RA, Jr., 1999. Cloning and characterization of human polyamine-modulated factor-1, a transcriptional cofactor that regulates the transcription of the spermidine/spermine N(1)-acetyltransferase gene. J Biol Chem 274: 22095-22101.
34. Wolff AC, Armstrong DK, Fetting JH, Carducci MK, Riley CD, Bender JF, Casero RA, Jr., Davidson NE,. 2003. A Phase II study of the polyamine analog N1,N11-diethylnorspermine (DENSpm) daily for five days every 21 days in patients with previously treated metastatic breast cancer. Clin Cancer Res 9: 5922-5928.
35. Yuan Q, Ray RM, Viar MJ, Johnson LR,. 2001. Polyamine regulation of ornithine decarboxylase and its antizyme in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 280: G130-G138.
36. Yusa N, Watanabe K, Yoshida S, Shirafuji N, Shimomura S, Tani K, Asano S, Sato N,. 2000. Transcription factor Sp3 activates the liver/bone/kidney-type alkaline phosphatase promoter in hematopoietic cells. J Leukoc Biol 68: 772-777.