Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics

Channels

Volumn 7, Issue 4, 2013, Pages 263-274

  Wang, Ging Kuo ^a   Russell, Gabriella ^a   Wang, Sho Ya ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Batrachotoxin; Cardiac sodium channel; Class 1 antiarrhythmic agents; HNav1.5; Inactivation deficient sodium channel; Local anesthetics; Persistent late sodium current; Stable cell line; Tetrodotoxin

Indexed keywords

ANTIARRHYTHMIC AGENT; BATRACHOTOXIN; DISOPYRAMIDE; FLECAINIDE; LIDOCAINE; MEXILETINE; QUINIDINE; SODIUM CHANNEL NAV1.5; TETRODOTOXIN; SCN5A PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IC 50; MAMMAL CELL; PROTEIN EXPRESSION; SODIUM CURRENT; CHANNEL GATING; DRUG EFFECTS; ELECTROPHYSIOLOGY; GENETIC TRANSFECTION; GENETICS; HEART MUSCLE CELL; HEK293 CELL LINE; METABOLISM; MUTATION; TIME;

MAMMALIA;

ANTI-ARRHYTHMIA AGENTS; BATRACHOTOXINS; ELECTROPHYSIOLOGICAL PROCESSES; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MUTATION; MYOCYTES, CARDIAC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; TIME FACTORS; TRANSFECTION;

EID: 84885589172     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.25056     Document Type: Article

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