Two conformational states involved in the use-dependent TTX blockade of human cardiac Na+ channel

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 270, Issue 6 39-6, 1996, Pages

  Dumaine, Robert ^a,b   Hartmann, Hali A ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

site directed mutagenesis; tetrodotoxin; use dependent block; Xenopus oocytes

Indexed keywords

SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CONFORMATION; ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HUMAN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; XENOPUS LAEVIS;

EID: 33750840351     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.270.6.h2029     Document Type: Article

References (30)

1. Aiyar, A., and J. Leis. Modification of the megaprimer method of PCR mutagenesis: improved amplification of the final product. BioTechniques 14: 366-369, 1993.
2. Aldrich, R. W., D. P. Corey, and C. F. Stevens. A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature Lond. 306: 436-441, 1983.
3. Baer, M., P. M. Best, and H. Reuter. Voltage dependent action of tetrodotoxin in mammalian cardiac muscle. Nature Lond. 263: 344-345, 1976.
4. Bezanilla, F., and C. M. Armstrong. Activation of the sodium channel. I. Sodium current experiments. J. Gen. Physiol. 79: 21-40, 1977.
5. Carmeliet, E. Voltage-dependent block by tetrodotoxin of the sodium channel in rabbit cardiac Purkinje fibres. Biophys. J. 51: 109-114, 1987.
6. Chernoff, D. M. Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine. Biophys. J. 58: 53-68, 1990.
7. Clarkson, C. W., T. Matsubara, and L. Hondeghem. Evidence for voltage dependent block of cardiac sodium channels by tetrodotoxin. J. Mol. Cell. Cordial. 20: 1119-1131, 1988.
8. Cohen, C. J., B. P. Bean, T. J. Colatsky, and R. W. Tsien. Tetrodotoxin block of sodium channels in rabbit Purkinje fibers: interactions between toxin binding and channel gating. J. Gen. Physiol. 78: 383-411, 1981.
9. Colquhoun, D., and A. G. Hawkes. Relaxation and fluctuations of membrane currents that flow through drug-operated channels. Proc. R. Soc. Lond. B Biol. Sci. 199: 231-262, 1977.
10. Drewe, J. A., H. A. Hartmann, and G. E. Kirsch. Potassium channels in mammalian brain: a molecular approach. In: Methods in Neuroscience, edited by T. Narahashi. San Diego, CA: Academic, 1994, vol. 19 p. 243-209.
11. Dugas, M., P. Honerjäger, and U. Masslich. Tetrodotoxin block of single germitrine-activated sodium channels in cultured rat cardiac cells. J. Physiol. Lond. 411: 611-626, 1989.
12. Eickhorn, R. J., J. Weinrich, D. Hornung, and H. Antoni. Use dependence of sodium current inhibition by tetrodotoxin in rat cardiac muscle: influence of channel state. Pfluegers Arch. 416: 398-405, 1990.
13. + channel inactivation gating. Circ. Res. 75: 114-122, 1994.
14. Hodgkin, A. L., and A. F. Huxley. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. Lond. 117: 500-544, 1952.
15. Huang, L. M., A. Yatani, and A. M. Brown. The properties of batrachotoxin-modified cardiac Na channels, including state dependent block by tetrodotoxin. J. Gen. Physiol. 90: 341-360, 1985.
16. Lonnendonker, U. Use-dependent block of sodium channels in frog myelinated nerve by tetrodotoxin and saxitoxin at negative holding potentials. Biochim. Biophys. Acta 985: 153-160, 1989.
17. Makielski, J. C., J. Satin, and Z. Fan. Post-repolarization block of cardiac sodium channels by saxitoxin. Biophys. J. 65: 790-798, 1993.
18. Moorman, J. R., G. E. Kirsch, A. M. Brown, and R. H. Joho. Changes in sodium channel gating produced by point mutations in the cytoplasmic linker. Science Wash. DC 250: 688-691, 1990.
19. Narahashi, T. Chemicals as tools in the study of excitable membranes. Physiol. Rev. 54: 813-889, 1974.
20. + channels. Physiol. Rev. 71: 1047-1079, 1991.
21. Patton, D. E., and A. L. Goldin. A voltage-dependent gating transition induces use-dependent block by tetrodotoxin of rat IIa sodium channels expressed in Xenopus oocytes. Neuron 7: 637-647, 1991.
22. +-channel inactivation: charge neutralizations and deletions in the III-IV linker. Proc. Natl. Acad. Sci. USA 89: 10905-10909, 1992.
23. Ritchie, J. M., and R. B. Rogart. The binding of saxitoxin and tetrodotoxin to excitable tissue. Rev. Physiol. Biochem. Pharmacol. 79: 1-50, 1977.
24. Salgado, V. L., J. Z. Yeh, and T. Naharashi. Use- and voltage-dependent block of the sodium channel by saxitoxin. In: Tetrodotoxin, Saxitoxin and the Molecular Biology of the Sodium Channel, edited by C. Y. Kao and S. R. Levinson. New York: NY Acad. Sci., 1986, vol. 479, p. 84-95.
25. Satin, J., J. W. Kyle, Z. Fan, R. Rogart, and H. A. Fozzard. Post repolarization block of cloned sodium channels by saxitoxin: the contribution of pore-region amino acids. Biophys. J. 66: 1353-1363, 1993.
26. Strichartz, G. R. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J. Gen. Physiol. 62: 37-57, 1973.
27. Stühmer, W., F. Conti, H. Suzuki, X. Wang, M. Noda, N. Yahadi, H. Kubo, and S. Noma. Structural parts involved in activation and inactivation of the sodium channel. Nature Lond. 339: 597-603, 1989.
28. Ulbricht, W., H. H. Wagner, and J. Schmidtmayer. Kinetics of TTX-STX block of sodium channels. In: Tetradotoxin, Saxitoxin and the Molecular Biology of the Sodium Channel, edited by C. Y. Kiao and S. R. Levinson. New York: NY Acad. Sci., 1986, vol. 479, p. 68-83.
29. Vassilev, P. M., R. W. Hadley, K. S. Lee, and J. R. Hume. Voltage dependent action of tetrodotoxin in mammalian cardiac myocytes. Am. J. Physiol. 251 (Heart Circ. Physiol. 20): H475-H480, 1986.
30. +-channel inactivation. Proc. Natl. Acad. Sci. USA 89: 10910-10914, 1992.