Mitochondrial Changes in Aging with Particular Reference to Muscle, and Possible Clinical Consequences

Muscle Aging, Inclusion-Body Myositis and Myopathies

Volumn , Issue , 2011, Pages 81-88

  DiMauro, Salvatore ^a   Schon, Eric ^a   Hirano, Michio ^a  

^a Department of Medicine   (United States)

Author keywords

Apoptosis; Dietary restriction; Exercise; Mitochondria; Mitochondrial DNA; MtDNA; Oxidative stress

Indexed keywords

EID: 84885529926     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444398311.ch4     Document Type: Chapter

References (61)

1. Wallace DC. (2005) A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer. A dawn for evolutionary medicine. Annu Rev Genet 39, 359-407.
2. Harman, D. (1981) The aging process. Proc Natl Acad Sci USA 78, 7124-7128.
3. Soong NW, Hinton DR, Cortopassi G, Arnheim, N. (1992) Mosaicism for a specific mitochondrial DNA mutation in adult human brain. Nat Genet 2, 318-323.
4. Harding AE. (1992) Growing old: the most common mitochondrial disease of all?. Nat Genet 2, 251-252.
5. Bua E, Johnson J, Herbst A et al. (2006) Mitochondrial DNA-deletion mutation accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers. Am J Hum Genet 79, 469-480.
6. Lang T, Streeper T, Cawton P et al. (2010) Sarcopenia: etiology, clinical consequences, intervention, and assessment. Osteoporos Int 21, 543-559.
7. Arnold A-S, Egger A, Hansdschin C. (2011) PGC-1 alpha and myokines in the aging muscle - A minireview. Gerontology 57, 37-43.
8. Bua E, McKiernan SH, Waganat J et al. (2002) Mitochondrial abnormalities are more frequent in muscle undergoing sarcopenia. J Appl Physiol 92, 2617-2624.
9. Muller-Hocker, J. (1992) Mitochondria and ageing. Brain Pathol 2, 149-158.
10. DiMauro S, Schon EA. (2003) Mitochondrial respiratory- chain diseases. New Engl J Med 348, 2656-2668.
11. Johnston W, Karpati G, Carpenter S et al. (1995) Late-onset mitochondrial myopathy. Ann Neurol 37, 16-23.
12. Simonetti S, Chen X, DiMauro S, Schon EA. (1992) Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR. Biochim Biophys Acta 1180, 113-122.
13. Pallotti F, Chen X, Bonilla E, Schon EA. (1996) Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am J Hum Genet 59, 591-602.
14. Cortopassi GA, Arnheim, N. (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res 18, 6927-6933.
15. Schon EA, Rizzuto R, Moraes CT et al. (1989) A direct repeat is a hotspot for large-scale deletions of human mitochondrial DNA. Science 244, 346-349.
16. Cortopassi GA, Shibata D, Soong NW, Arnheim, N. (1992) A pattern of accumulation of a somatic deletion of mitochondrialDNAin aginghumantissues. Proc Natl Acad Sci USA 89, 7370-7374.
17. Moraes CT, DiMauro S, Zeviani M et al. (1989) Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearns-Sayre syndrome. NEngl J Med 320, 1293-1299.
18. Chen X, Simonetti S, DiMauro S, Schon EA. (1993) Accumulations of mitochondrial DNA deletions in organisms with various lifespans. Bull Mol Biol Med 18, 57-66.
19. Melov S, Shoffner JM, Kaufman A, Wallace DC. (1995) Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acid Res 23, 4122-4126.
20. Melov S, Hinerfeld D, Esposito L, Wallace DC. (1997) Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age. Nucleic Acid Res 25, 974-982.
21. Cao Z, Waganat J, McKiernan SH, Aiken JM. (2001) Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: analysis by laser-capture microdissection. Nucleic Acids Res 29, 4502-4508.
22. Waganat J, Cao Z, Pathare P, Aiken JM. (2001) MitochondrialDNAdeletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia. FASEB J 15, 322-332.
23. Chomyn A, Martinuzzi A, Yoneda M et al. (1992) MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proc Natl Acad Sci USA 89, 4221-4225.
24. Chinnery PF, Taylor DJ, Brown DT et al. (2000) Very low levels of the mtDNA A3243G mutation associated with mitochondrial dysfunction in vivo. Ann Neurol 47, 381-384.
25. Munscher C, Rieger T, Muller-Hocker J, Kadenbach, B. (1993) The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages. FEBS Lett 317, 27-30.
26. Munscher C, Muller-Hocker J, Kadenbach, B. (1993) Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA. Biol Chem Hoppe Seyler 374, 1099-1104.
27. Zhang C, LinnaneAW, Nagley, P. (1993) Occurrence of a particular base substitution (3243 A to G) in mitochondrial DNA of tissues of aging humans. Biochem Biophys Res Commun 195, 1104-1110.
28. Fayet G, Jansson M, Sternberg D et al. (2000) Mitochondrial DNA mutations in cytochrome c oxidase deficient muscle fibers associated with aging. Neuromusc Disord 10, 346.
29. Wang Y, Michikawa Y, Mallidis C et al. (2001) Musclespecific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci USA 98, 4022-4027.
30. Trifunovic A, Wredenberg A, Falkenberg M et al. (2004) Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429, 417-423.
31. Kujoth GC, Hiona A, Pugh TD et al. (2005) Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science 309, 481-484.
32. Trifunovic A, Hansson A, Wredenberg A et al. (2005) Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production. Proc Natl Acad Sci USA 102, 17993-17998.
33. Khrapko K, Kraytsberg Y, de GreyADet al. (2006) Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging?. Aging Cell 5, 279-282.
34. Vermulst M, Bielas JH, Kujoth GC et al. (2007) Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet 39, 540-543.
35. Boffoli D, Scacco SC, Vergari R et al. (1994) Decline with age of the respiratory chain activity in human skeletal muscle. Biochim Biophys Acta 1236, 73-82.
36. Byrne E, Dennett X, Trounce, I. (1991) Oxidative energy failure in post-mitotic cells: A major factor in senescence. Rev Neurol 147, 532-535.
37. Cardellach F, Galofre J, Cusso, R. (1989) Decline in skeletal muscle mitochondrial respiratory chain function with ageing. Lancet 2, 637-639.
38. Cooper JM, MannVM, Schapira AH. (1992) Analysis of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: effect of ageing. J Neurol Sci 113, 91-98.
39. Hseih RH, Hou JH, Hsu HS, Wei YH. (1994) Agedependent respiratory function decline and DNA deletions in human muscle mitochondria. Biochem Mol Biol Intern 32, 1009-1022.
40. Papa, S. (1996) Mitochondrial oxidative phosphorylation changes in the life span. Molecular aspects and physiopathological implications. Biochem Biophys Acta 1276, 87-105.
41. Trounce I, Byrne E, Marzuki, S. (1989) Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing. Lancet 1, 637-639.
42. Zahn JM, Sonu R, Vogel H et al. (2006) Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet 2, e115.
43. Marzetti E, Hwang JCY, Lees HA et al. (2010) Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy. Biochim Biophys Acta 1800, 235-244.
44. Guarente, L. (2008) Mitochondria - a nexus for aging, calorie restriction, and sirtuins?. Cell 132, 171-176.
45. Melov S, Ravenscroft J, Malik S et al. (2000) Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 1567-1569.
46. Jang YC, Lustgarten MS, Liu Y et al. (2010) Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J 24, 1376-1390.
47. Marzetti E, Leeuwenburgh, C. (2006) Skeletal muscle apoptosis, sarcopenia and frailty at old age. Exp Geront 41, 1234-1238.
48. Lin J, Wu, H., Tarr PT et al. (2002) Transcriptional co-activator PGC-1alpha drives the formation of slowtwitch muscle fibers. Nature 418, 797801.
49. Rohas LM, St-Pierre J, Uldry M et al. (2007) A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proc Natl Acad Sci USA 104, 7933-7938.
50. Ling C, Poulsen P, Carlsson E et al. (2004) Multiple environmental and genetic factors influence skeletal muscle PGC1-alpha and PGC-1beta gene expression in twins. J Clin Invest 114, 1518-1526.
51. Handschin C, Spiegelman BM. (2006) Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev 27, 728-735.
52. Reznick RM, Zong H, Morino K et al. (2007) Agingassociated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab 5, 151-156.
53. Wenz T, Diaz F, Spiegelman BM, Moraes CT. (2008) Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab 8, 249-255.
54. Wenz T, Rossi S, Rotundo RL et al. (2009) Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci USA 106, 20405-20410.
55. Wenz T, Diaz F, Hernandez D, Moraes CT. (2009) Endurance exercise is protective for mice with mitochondrial myopathy. J Appl Physiol 106, 1712-1719.
56. Wenz, T. (2009) PGC-1alpha activation asa therapeutic approach in mitochondrial disease. IUBMB Life 61, 1051-1062.
57. Pilegaard H, Saltin B, Neufer PD. (2003) Exercise induces transient transcriptional activation of the PGC- 1alpha gene in human skeletal muscle. J Physiol 546, 851-858.
58. Mathai AS, Bonen A, Benton CR et al. (2008) Rapid exercise-induced changes in PGC-1alpha mRNA and protein in human skeletal muscle. J Appl Physiol 105, 1098-1105.
59. Taivassalo T, Shoubridge EA, Chen J et al. (2001) Aerobic conditioning in patients with mitochondrial myopathies: physiological, biochemical, and genetic effects. Ann Neurol 50, 133-141.
60. Sandri M, Lin J, Handschin C et al. (2006) PGC- 1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and arophy-specific gene transcription. Proc Natl Acad Sci USA 103, 16260-16265.
61. Civitarese AE, Carling S, Heilbronn LK et al. (2007) Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 4, e76.