Aerobic conditioning in patients with mitochondrial myopathies: Physiological, biochemical, and genetic effects

Annals of Neurology

Volumn 50, Issue 2, 2001, Pages 133-141

  Taivassalo, Tanja ^a   Shoubridge, Eric A ^b   Chen, Jacqueline ^b   Kennaway, Nancy G ^e   Dimauro, Salvatore ^b   Arnold, Douglas L ^c   Haller, Ronald G ^d  

^a PRESBYTERIAN HOSPITAL OF DALLAS   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d Columbia University College of Physicians and Surgeons ^*  (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AEROBIC CAPACITY; AEROBIC METABOLISM; ARTICLE; BICYCLE; CLINICAL ARTICLE; EXERCISE; FEMALE; GENE MUTATION; HUMAN; MALE; MITOCHONDRIAL MYOPATHY; MUSCLE BIOPSY; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; PRIORITY JOURNAL; SKELETAL MUSCLE;

ADULT; BIOPSY, NEEDLE; EXERCISE; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MITOCHONDRIAL MYOPATHIES; MUSCLES; TIME FACTORS;

EID: 0034905495     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.1050     Document Type: Article

References (41)

1. Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
2. Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy
3. Mitochondrial genetics and human disease
4. Mitochondrial diseases in man and mouse
5. Skeletal muscle adaptability: Significance for metabolism and performance
6. Effects of aerobic training in patients with mitochondrial myopathies
7. Exercise intolerance, lactic acidosis, and abnormal cardiopulmonary regulation in exercise associated with adult skeletal muscle cytochrome c oxidase deficiency
8. Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA
9. Exercise intolerance due to a nonsense mutation in the mtDNA ND4 gene
10. A microdeletion in cytochrome c oxidase (COX) subunit III associated with COX deficiency and recurrent myoglobinuria
11. A novel mutation in the mitochondrial tRNATrp gene in a sporadic case of mitochondrial myopathy
12. Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA
13. Non-invasive determination of cardiac output by a modified acetylene rebreathing procedure utilizing mass spectrometer
14. The cardiac output - Oxygen uptake relationship of men during graded bicycle ergometry
15. ADP recovery after a brief ischemic exercise in normal and diseased human muscle - A 31P MRS study
16. Fitting cytosolic ADP recovery after exercise with a step response function
17. Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: An analytical review
18. Cytochrome oxidase from beef heart mitochondria
19. Deficiency of the iron-sulfur clusters of mitochondrial reduced nicotinamide-adenine dinulcleotide-ubiquinone oxidoreductase (Complex I) in an infant with lactic acidosis
20. Laboratory diagnosis of mitochondrial disease
21. An enzymatic approach to the study of the Krebs tricarboxylic acid cycle
22. Mitochondrial DNA depletion: Prevalence in a pediatric population referred for neurologic evaluation
23. Mechanical and physiological calibration of four cycle ergometers
24. Deficiency of skeletal muscle succinate dehydrogenase and aconitase. Pathophysiology of exercise in a novel human muscle oxidative defect
25. Maximal oxygen uptake
26. Circulatory regulation in muscle disease
27. Quantitative analysis by 31P magnetic resonance spectroscopy of abnormal mitochondrial oxidation in skeletal muscle during recovery from exercise
28. Abnormal oxidative metabolism in exercise intolerance of undetermined origin
29. Metabolic recovery after exercise and the assessment of mitochondrial function in vivo in human skeletal muscle by means of 31P NMR
30. Bioenergetics of intact human muscle. A 31P nuclear magnetic resonance study
31. Time course of changes in human skeletal muscle succinate dehydrogenase and cytochrome oxidase activities and maximal oxygen uptake with physical activity and inactivity
32. Assembly of the cellular powerhouse: Current issues in muscle mitochondrial biogenesis
33. Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease
34. Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions
35. A new mtDNA mutation showing accumulation with time and restriction to skeletal muscle
36. Mitochondrial DNA (mtDNA) diseases: Correlation of genotype to phenotype
37. The kinetic basis of threshold effects observed in mitochondrial diseases: A systemic approach
38. MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts
39. Progressive increase of the mutated mitochondrial DNA fraction in Kearns-Sayre syndrome
40. Single muscle fiber analysis of myoclonus epilepsy with ragged-red fibers
41. Distribution and threshold expression of the tRNALys mutation in skeletal muscle of patients with myoclonic epilepsy and ragged-red fibers (MERRF)