New water-soluble ruthenium(II) cytotoxic complex: Biological activity and cellular distribution

Journal of Inorganic Biochemistry

Volumn 130, Issue 1, 2014, Pages 1-14

  Morais, Tânia S ^a   Santos, Filipa C ^a   Jorge, Tiago F ^a   Côrte Real, Leonor ^b   Madeira, Paulo J Amorim ^a   Marques, Fernanda ^b   Robalo, M Paula ^c,d   Matos, António ^a,e   Santos, Isabel ^b   Garcia, M Helena ^a  

^a UNIVERSITY OF LISBON   (Portugal)

^b INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^c INSTITUTO SUPERIOR DE ENGENHARIA DE LISBOA   (Portugal)

^d INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^e INSTITUTO SUPERIOR DE CIÊNCIAS DA SAÚDE EGAS MONIZ   (Portugal)

Author keywords

Albumin; Cellular uptake; Cyclopentadienyl; Cytotoxicity; Ruthenium; Ubiquitin

Indexed keywords

CISPLATIN; CYTOCHROME C; RUTHENIUM; UBIQUITIN; WATER;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CELL DAMAGE; CELL DEATH; CELL MEMBRANE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG SOLUBILITY; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; ENDOCYTOSIS; FLOW CYTOMETRY; GOLGI COMPLEX; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; LOW TEMPERATURE; MASS SPECTROMETRY; MITOCHONDRION; MOLECULAR MECHANICS; SOLUBILITY; TEMPERATURE DEPENDENCE; TRANSMISSION ELECTRON MICROSCOPY;

ALBUMIN; CELLULAR UPTAKE; CYCLOPENTADIENYL; CYTOTOXICITY; RUTHENIUM; UBIQUITIN;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COORDINATION COMPLEXES; CYTOCHROMES C; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROCHEMICAL TECHNIQUES; ENDOCYTOSIS; FLUORESCENCE; GOLGI APPARATUS; HUMANS; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; SERUM ALBUMIN; SOLUBILITY; TEMPERATURE; UBIQUITIN; WARFARIN; WATER;

EID: 84885498325     PISSN: 01620134     EISSN: 18733344     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2013.09.013     Document Type: Article

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