Decreased expression of serotonin in the jejunum and increased numbers of mast cells in the terminal ileum inpatients with irritable bowel syndrome

World Journal of Gastroenterology

Volumn 13, Issue 45, 2007, Pages 6041-6047

  Wang, Shen Hao ^a   Dong, Lei ^a   Luo, Jin Yan ^a   Gong, Jun ^a   Li, Lu ^a   Lu, Xiao Lan ^a   Han, Shui Ping ^b  

^a THE SECOND AFFILIATED HOSPITAL OF XI AN JIAOTONG UNIVERSITY   (China)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

Author keywords

Enterochromaffin cell; Irritable bowel syndrome; Mast cell; Serotonin; Small intestinal mucosa

Indexed keywords

SEROTONIN;

ADULT; AGED; ARTICLE; CELL COUNT; CELLULAR DISTRIBUTION; COLONOSCOPY; CONSTIPATION; CONTROLLED STUDY; DIARRHEA; ELECTROCHEMISTRY; ENTEROCHROMAFFIN CELL; FEMALE; GASTROINTESTINAL ENDOSCOPY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; IRRITABLE COLON; MALE; MAST CELL; PATHOGENESIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMALL INTESTINE;

EID: 36949037766     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.13.6041     Document Type: Article

References (28)

1. Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology 2002; 123: 2108-2131
2. Han SH, Lee OY, Bae SC, Lee SH, Chang YK, Yang SY, Yoon BC, Choi HS, Hahm JS, Lee MH, Lee DH, Kim TH. Prevalence of irritable bowel syndrome in Korea: population-based survey using the Rome II criteria. J Gastroenterol Hepatol 2006; 21: 1687-1692
3. Pare P, Gray J, Lam S, Balshaw R, Khorasheh S, Barbeau M, Kelly S, McBurney CR. Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: baseline results from LOGIC (Longitudinal Outcomes Study of Gastrointestinal Symptoms in Canada), a naturalistic study. Clin Ther 2006; 28: 1726-1735; discussion 1710-1711
4. Lau EM, Chan FK, Ziea ET, Chan CS, Wu JC, Sung JJ. Epidemiology of irritable bowel syndrome in Chinese. Dig Dis Sci 2002; 47: 2621-2624
5. Si JM, Chen SJ, Sun LM. An epidemiological and quality of life study of irritable bowel syndrome in Zhejiang province. Zhonghua Neike Zazhi 2003; 42: 34-37
6. Mawe GM, Coates MD, Moses PL. Review article: intestinal serotonin signalling in irritable bowel syndrome. Aliment Pharmacol Ther 2006; 23: 1067-1076
7. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology 2006; 130: 1480-1491
8. Harris LA, Chang L. Irritable bowel syndrome: new and emerging therapies. Curr Opin Gastroenterol 2006; 22: 128-135
9. Gershon MD. Nerves, reflexes, and the enteric nervous system: pathogenesis of the irritable bowel syndrome. J Clin Gastroenterol 2005; 39: S184-S193
10. Barbara G, Stanghellini V, De Giorgio R, Corinaldesi R. Functional gastrointestinal disorders and mast cells: implications for therapy. Neurogastroenterol Motil 2006; 18: 6-17
11. Crowell MD. Role of serotonin in the pathophysiology of the irritable bowel syndrome. Br J Pharmacol 2004; 141: 1285-1293
12. Coates MD, Mahoney CR, Linden DR, Sampson JE, Chen J, Blaszyk H, Crowell MD, Sharkey KA, Gershon MD, Mawe GM, Moses PL. Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome. Gastroenterology 2004; 126: 1657-1664
13. Bian X, Patel B, Dai X, Galligan JJ, Swain G. High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression. Gastroenterology 2007; 132: 2438-2447
14. van Lelyveld N, Ter Linde J, Schipper ME, Samsom M. Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum. Neurogastroenterol Motil 2007; 19: 342-348
15. Liu H, Irving HR, Tan YY, Meng L, Chetty N, Coupar IM. Influences of gender and region on responses to 5-HT in the rat small intestine. Pharmacology 2004; 72: 220-224
16. Wang ZJ, Ouyang Q, Zou YG, Peng L, Wang YF. Comparison of intestinal mucosal monamine neurotransmitter of ulcerative colitis and irritable bowel syndrome. Zhonghua Neike Zazhi 2005; 11: 851-852
17. Miwa J, Echizen H, Matsueda K, Umeda N. Patients with constipation-predominant irritable bowel syndrome (IBS) may have elevated serotonin concentrations in colonic mucosa as compared with diarrhea-predominant patients and subjects with normal bowel habits. Digestion 2001; 63: 188-194
18. Dunlop SP, Jenkins D, Spiller RC. Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. Am J Gastroenterol 2003; 98: 1578-1583
19. Dunlop SP, Jenkins D, Neal KR, Spiller RC. Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology 2003; 125: 1651-1659
20. Spiller RC, Jenkins D, Thornley JP, Hebden JM, Wright T, Skinner M, Neal KR. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000; 47: 804-811
21. Li ZS, Zhan LX, Zou DW, Xu GM, Man XH, Ye XT. Morphological and functional alteration of serotonin-producing intestinal enterochromatin in cells in patients with irritable bowel syndrome. Zhonghua Xiaohua Zazhi 2004; 24: 94-97
22. Jiang M, Lin LP, Fu BY. Distribution feature of colonic 5-HT in irritable bowel syndrome. Shijie Huaren Xiaohua Zazhi 2005; 13: 541-543
23. Park JH, Rhee PL, Kim HS, Lee JH, Kim YH, Kim JJ, Rhee JC. Mucosal mast cell counts correlate with visceral hypersensitivity in patients with diarrhea predominant irritable bowel syndrome. J Gastroenterol Hepatol 2006; 21: 71-78
24. Stead RH. Innervation of mucosal immune cells in the gastrointestinal tract. Reg Immunol 1992; 4: 91-99
25. Barbara G, Stanghellini V, De Giorgio R, Cremon C, Cottrell GS, Santini D, Pasquinelli G, Morselli-Labate AM, Grady EF, Bunnett NW, Collins SM, Corinaldesi R. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126: 693-702
26. Dong WZ, Li ZS, Zou DW, Xu GM, Zou XP, Zhu AY, Yin N, Gong YF. The changes of mucosal mast cells and substance P in patients with irritable bowel syndrome. Zhonghua Neike Zazhi 2003; 42: 611-614
27. Chen WK, Zou YY, Li FJ, Luo D. Changes of psychosocial factors, enteric mucosal mast cells and 5-hydroxytryptamine in irritable bowel syndrome. Shijie Huaren Xiaohua Zazhi 2007; 15: 46-50
28. Phillips SF, Camilleri M. The ileocecal area and the irritable bowel syndrome. Gastroenterol Clin North Am 1991; 20: 297-311