Enhancement of PLGF production by 15-(S)-HETE via PI3K-Akt, NF-κB and COX-2 pathways in rheumatoid arthritis synovial fibroblast

European Journal of Pharmacology

Volumn 714, Issue 1-3, 2013, Pages 388-396

  Wu, Ming Yueh ^a   Yang, Rong Sen ^a   Lin, Tzu Hung ^a   Tang, Chih Hsin ^b   Chiu, Yung Cheng ^c   Liou, Houng Chi ^a   Fu, Wen Mei ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

15 lipoxygenase; COX 2; Inflammation; PLGF; Synovial fibroblasts

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PLACENTAL GROWTH FACTOR; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; PROTEIN KINASE B; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROBLAST; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SYNOVIUM; UPREGULATION;

15-LIPOXYGENASE; COX-2; INFLAMMATION; PLGF; SYNOVIAL FIBROBLASTS;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; ARTHRITIS, RHEUMATOID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; FIBROBLASTS; GENE KNOCKOUT TECHNIQUES; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PREGNANCY PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; UP-REGULATION;

EID: 84885470455     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.07.010     Document Type: Article

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