Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism

Toxicology and Applied Pharmacology

Volumn 163, Issue 3, 2000, Pages 221-230

  Jiang, Nanfei ^a   Dreher, Kevin L ^b   Dye, Janice A ^b   Li, Yuehua ^a   Richards, Judy H ^b   Martin, Linda D ^a   Adler, Kenneth B ^a  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cytotoxicity; Mucin; Oxidant; Residual oil fly ash

Indexed keywords

BUTHIONINE SULFOXIMINE; DIMETHYLTHIOUREA; GLUTATHIONE; IRON; LACTATE DEHYDROGENASE; MESSENGER RNA; MONOCLONAL ANTIBODY; MUCIN; NICKEL; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; VANADIUM;

AIR POLLUTION; AMBIENT AIR; ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ELECTRIC POWER PLANT; ENZYME LINKED IMMUNOSORBENT ASSAY; FLY ASH; GUINEA PIG; IN VITRO STUDY; NONHUMAN; OXIDATIVE STRESS; PARTICULATE MATTER; PROTEIN SECRETION; TRACHEA MUCOSA;

ANIMALIA; BRONCHUS; CAVIA PORCELLUS; SUS SCROFA;

EID: 0034654155     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1999.8886     Document Type: Article

References (49)

1. Adler K. B., Akley N. J., Glasgow W. C. Platelet-activating factor provokes release of mucin-like glycoproteins from guinea pig respiratory epithelial cells via a lipoxygenase-dependent mechanism. Am. J. Respir. Cell Mol. Biol. 6:1992;550-556.
2. Adler K. B., Cheng P. W., Kim K. C. Characterization of guinea pig tracheal epithelial cells maintained in biphasic organotypic culture: Cellular composition and biochemical analysis of released glycoconjugates. Am. J. Respir. Cell Mol. Biol. 2:1990a;145-154.
3. Adler K. B., Fisher B. M., Li H., Choe N. H., Wright D. T. Hypersecretion of mucin in response to inflammatory mediators by guinea pig tracheal epithelial cells in vitro is blocked by inhibition of nitric oxide synthase. Am. J. Respir. Cell Mol. Biol. 13:1995;526-530.
4. Adler K. B., Holden-Stauffer W. J., Repine J. E. Oxygen metabolites stimulate release of high-molecular-weight glycoconjugates by cell and organ cultures of rodent respiratory epithelium via an arachidonic acid-dependent mechanism. J. Clin. Invest. 85:1990b;75-85.
5. Anderson M. E. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol. 113:1985;548-555.
6. Byrne A. R., Kosta L. Vanadium in foods and human body fluids and tissues. Sci. Total Environ. 10:1978;17-30.
7. Cohn L. A., Kinnula V. L., Adler K. B. Antioxidant properties of guinea pig tracheal epithelial cells in vitro. Am. J. Physiol. (London). 266:1994;L397-L404.
8. Costa D. L., Dreher K. L. Bioavailable metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environ. Health Perspect. 105:1997;1053-1060.
9. Ding M., Li J. J., Leonard S. S., Ye J. P., Shi X., Colburn N. H., Castranova V., Vallyathan V. Vanadate-induced activation of activator protein-1: Role of reactive oxygen species. Carcinogenesis. 20:1999;663-668.
10. Dockery D. W., Pope C. A. III. Acute respiratory effects of particulate air pollution. Annu. Rev. Public Health. 15:1994;107-132.
11. Dreher K., Jaskot R., Kodavanti U., Lehmann J., Winsett D., Costa D. Soluble transition metals mediate the acute pulmonary injury and airway hyperreactivity induced by residual oil fly ash particles. Chest. 109:1996;33S-34S.
12. Dreher K. L., Jaskot R. H., Lehmann J. R., Richard J. H., McGee J. K., Ghio A. J., Costa D. L. Soluble transition metals mediate residual oil fly ash induced acute lung injury. J. Toxicol. Environ. Health. 50:1997;285-305.
13. Dye J. A., Adler K. B., Richards J. H., Dreher K. L. Injury of rat tracheal epithelia cultures by exposure to residual oil fly ash (ROFA) involves generation of hydroxyl radical-like reactive oxygen species. Am. J. Respir. Crit. Care Med. 153:1996.
14. Dye J. A., Adler K. B., Richards J. H., Dreher K. L. Epithelial injury induced by exposure to residual oil fly-ash particles: Role of reactive oxygen species. Am. J. Respir. Cell Mol. Bio. 17:1997;625-633.
15. Gad S. C., Weil C. S. Statistics for toxicologists. Hayes A. W. Principles and Methods of Toxicology. 1995;221-274 Raven Press, New York.
16. Gavett S. H., Madison S. L., Dreher K. L., Winsett D. W., McGee J. K., Costa D. L. Metal and sulfate composition of residual oil fly ash determines airway hyperreactivity and lung injury in rats. Environ. Res. 72:1997;162-172.
17. Grabowski G. M., Paulauskis J. D., Godleski J. J. Mediating phosphorylation events in the vanadium-induced respiratory burst of alveolar macrophages. Toxicol. Appl. Pharmacol. 156:1991;170-178.
18. Hatch G. E., Boykin E., Graham J. A., Lewatas J., Pott F., Loud K., Mumford J. L. Inhalable particles and pulmonary host defense: In vivo and in vitro effects of ambient air and combustion particles. Environ. Res. 36:1985;67-80.
19. Hauser R., Elreedy S., Ryan P. B., Christiani D.C. Urine vanadium concentrations in workers overhauling an oil-fired boiler. Am. J. Ind. Med. 33:1998;55-60.
20. Henry W. M., Knapp K. T. Compound forms of fossil fuel fly ash emissions. Environ. Sci. Technol. 14:1980;450-456.
21. Jany, B., Gallup, M., Tsuda, T., and Basbaum, C.1991. Mucin gene expression in rat airways following infection and irritation. Biochem. Biophys. Res. Commun.181, 1-8.
22. Jaskot R. H., Costa D. L., Kodavanti U. P., Lehmann J. R., Winsett D., Dreher K. Comparison of lung inflammation and airway reactivity in three strains of rats exposed to residual oil fly ash particles. Am. J. Respir. Crit. Care Med. 151:1995.
23. Keller R. J., Couloumbe R. A. Jr., Sharma R. P., Grover T. A., Piette L. H. Importance of hydroxyl radical in the vanadium-stimulated oxidation of NADH. Free Radic. Biol. Med. 6:1989;15-22.
24. Keller R. J., Sharma R. P., Grover T. A., Piette L. H. Vanadium and lipid peroxidation: Evidence for involvement of vanadyl and hydroxyl radical. Arch. Biochem. Biophys. 265:1988;524-533.
25. Kleeberger S. R., Levitt R. C., Zhang L. Y., Longphere M., Harkema J., Jedlicka A., Eleff S. M., Disilvestre D., Holroyd K. J. Linkage analysis of susceptibility to ozone-induced lung inflammation in inbred mice. Nat. Genet. 17:1997;475-478.
26. Kleinbaum D. G., Kupper L. L., Muller K. E. Applied Regression Analysis and Multivariate Methods. 1988;PWS-Kent, Boston.
27. Kresja C. M., Nadler S. G., Esselstyn J. M., Kavanaugh T. J., Ledbetter J. A., Schievan G. L. Role of oxidative stress in the action of vanadium phosphotyrosine phosphatase inhibitors. Redox independent activation of NF-kappaB. J. Biol. Chem. 272:1997;11541-11549.
28. Lees R. M. Changes in lung function after exposure to vanadium compounds in fuel oil fly ash. Br. J. Ind. Med. 37:1980;252-256.
29. Li C., Cheng P. W., Adler K. B. Production and characterization of monoclonal antibodies against guinea pig tracheal mucins. Hybridoma. 13:1994;281-287.
30. Li D., Gallup M., Fan N., Szymkowski D. E., Basbaum C. B. Cloning of the amino-terminal and 5′-flanking region of the human MUC5AC mucin gene and transcriptional up-regulation by bacterial exoproducts. J. Biol. Chem. 12:1998;6812-6820.
31. Li Y., Greenfeder S., Martin L. D., Minnicozzi M., Voynow J. A., Adler K. B. Cloning and expression of guinea pig Muc2 and Muc5AC genes. Am. J. Respir. Crit. Care Med. 159:1999.
32. Li Y., Martin L. D., Minnicozzi M., Adler K. B. Cloning of guinea pig MUC2 cDNA and MUC2 gene expression in guinea pig airway epithelium in vitro. Am. J. Respir. Crit. Care Med. 157:1998.
33. Longphere M., Bice D. E., Basbaum C. B. Bronchoalveolar lavage (BAL) from ragweed-challenged dogs stimulates mucin production in cultured airway epithelial cells. Am. J. Respir. Crit. Care Med. 157:1998.
34. Lundgren J. D., Shelhamer J. H. Pathogenesis of airway mucus hypersecretion. J. Allergy Clin. Immunol. 85:1998;399-417.
35. Oster M. H., Llobet J. M., Domingo J. L., German J. B., Keen C. L. Vanadium treatment of diabetic Sprague-Dawley rats results in tissue vanadium accumulation and pro-oxidant effects. Toxicology. 83:1993;115-130.
36. Parker N. B., Berger E. M., Curtis W. J., Muldrow M. E., Linas S. L., Repine J. E. Hydrogen peroxide causes dimethylthiourea consumption while hydroxyl radical causes dimethylsulfoxide consumption in vitro. Free Radic. Biol. Med. 1:1985;415-419.
37. Pritchard R. J., Ghio A. J., Lehmann L. R., Winsett D. W., Tepper J. S., Park P., Gilmour M. I., Dreher K. L., Costa D. L. Oxidant generation and lung injury after particulate air pollutant exposure increase with the concentrations of associated metals. Inhalation Toxicol. 8:1996;457-477.
38. Rieves R. D., Goff J., Wu T., Larivee P., Logun C., Shelhamer J. H. Airway epithelial cell mucin release: Immunologic quantitation and response to platelet-activating factor. Am. J. Respir. Cell Mol. Biol. 6:1992;158-167.
39. Rochelle L. G., Fischer B. M., Adler K. B. Concurrent measure of reactive oxygen and nitrogen species in airway epithelial cells in vitro. Free Radic. Biol. Med. 24:1998;863-868.
40. Rogers D. F. Airway goblet cells: Responsive and adaptable front-line defenders. Eur. Respir. J. 7:1994;1690-1706.
41. Samet J., Silbajouris R., Wu W., Graves L. M. Tyrosine phosphatases as targets in metal-induced signaling in human airway epithelial cells. Am. J. Respir. Cell Mol. Biol. 21:1999;357-364.
42. Samet J. M., Stonehuerner J., Reed W., Devlin R. B., Dailey L. A., Kennedy T. P., Bromberg P. A., Ghio A. J. Disruption of protein tyrosine phosphate homeostasis in bronchial epithelial cells exposed to oil fly ash. Am. J. Physiol. (London). 272:1997;L426-L432.
43. Schwartz J. Particulate air pollution and chronic respiratory disease. Environ. Res. 62:1993;7-17.
44. Southorn P., Powis G. Free radicals in medicine. II. Involvement in human disease. Mayo Clin. Proc. 63:1988;390-408.
45. Su W. Y., Kodavanti U. P., Jaskot R. H., Costa D. L., Dreher K. L. Temporal expression and cellular distribution of pulmonary fibronectin gene induction following exposure to an emission source particle. J. Environ. Pathol. Toxicol. Oncol. 14:1995;215-225.
46. Wasil M., Halliwell B., Grootveld M., Moorhouse C. P., Hutchison D. C. S., Baum H. The specificity of thiourea, dimethylthiourea, and dimethylsulphoxide as scavengers of hydroxyl radicals. Biochem. J. 243:1987;867-870.
47. Whiteman M., Halliwell B. Thiourea and dimethylthiourea inhibit peroxynitrite-dependent damage: Nonspecificity as hydroxyl radical scavengers. Free Radic. Biol. Med. 22:1997;1309-1312.
48. Wright D. T., Fischer B. M., Li C., Rochelle L. G., Akley N. J., Adler K. B. Oxidant stress stimulates mucin secretion and PLC in airway epithelium via a nitric oxide-dependent mechanism. Am. J. Physiol. (London). 271:1996;L854-L861.
49. Younes M., Albrecht M., Siegers C. P. Lipid peroxidation and lysosomal enzyme release induced by vanadate in vitro. Res. Commun. Chem. Pathol. Pharmacol. 43:1984;487-495.