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Volumn 405, Issue 26, 2013, Pages 8409-8417

VIZR - An automated chemometric technique for metabolic profiling

Author keywords

Biomarker detection; Chemometrics; Disease detection; Metabolomics; Metabonomics; NMR spectroscopy; Toxicological profiling; Z score

Indexed keywords

BODY FLUIDS; DIAGNOSIS; DIETARY SUPPLEMENTS; DISEASE CONTROL; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OPEN SOURCE SOFTWARE; OPEN SYSTEMS;

EID: 84885430814     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7254-x     Document Type: Article
Times cited : (4)

References (44)
  • 1
    • 84856682672 scopus 로고    scopus 로고
    • Urine metabolic signature of pancreatic ductal adenocarcinoma by H-1 nuclear magnetic resonance: Identification, mapping, and evolution
    • 10.1021/pr200960u 1:CAS:528:DC%2BC3MXhsVansLvP
    • Napoli C, Sperandio N, Lawlor RT, Scarpa A, Molinari H, Assfalg M (2012) Urine metabolic signature of pancreatic ductal adenocarcinoma by H-1 nuclear magnetic resonance: identification, mapping, and evolution. J Proteome Res 11:1274-1283
    • (2012) J Proteome Res , vol.11 , pp. 1274-1283
    • Napoli, C.1    Sperandio, N.2    Lawlor, R.T.3    Scarpa, A.4    Molinari, H.5    Assfalg, M.6
  • 2
    • 84865593022 scopus 로고    scopus 로고
    • Serum metabolomics as a novel diagnostic approach for disease: A systematic review
    • 10.1007/s00216-012-6117-1 1:CAS:528:DC%2BC38XnslKqu7Y%3D
    • Zhang A, Sun H, Wang X (2012) Serum metabolomics as a novel diagnostic approach for disease: a systematic review. Anal Bioanal Chem 404:1239-1245
    • (2012) Anal Bioanal Chem , vol.404 , pp. 1239-1245
    • Zhang, A.1    Sun, H.2    Wang, X.3
  • 3
    • 84155170857 scopus 로고    scopus 로고
    • Morphine-induced conditioned place preference in mice: Metabolomic profiling of brain tissue to find "molecular switch" of drug abuse by gas chromatography/mass spectrometry
    • 10.1016/j.aca.2011.09.033 1:CAS:528:DC%2BC3MXhsFegt7rM
    • Meng J, Zhang X, Wu H, Bu J, Shi C, Deng C, Mao Y (2012) Morphine-induced conditioned place preference in mice: metabolomic profiling of brain tissue to find "molecular switch" of drug abuse by gas chromatography/mass spectrometry. Anal Chim Acta 710:125-130
    • (2012) Anal Chim Acta , vol.710 , pp. 125-130
    • Meng, J.1    Zhang, X.2    Wu, H.3    Bu, J.4    Shi, C.5    Deng, C.6    Mao, Y.7
  • 4
    • 84861226161 scopus 로고    scopus 로고
    • Metabonomic analysis of saliva reveals generalized chronic periodontitis signature
    • 10.1007/s11306-011-0331-2 1:CAS:528:DC%2BC38XmvFGnt7Y%3D
    • Aimetti M, Cacciatore S, Graziano A, Tenori L (2012) Metabonomic analysis of saliva reveals generalized chronic periodontitis signature. Metabolomics 8:465-474
    • (2012) Metabolomics , vol.8 , pp. 465-474
    • Aimetti, M.1    Cacciatore, S.2    Graziano, A.3    Tenori, L.4
  • 5
    • 0030611827 scopus 로고    scopus 로고
    • 750 MHz H-1 NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease
    • 10.1016/S0731-7085(97)00066-6 1:CAS:528:DyaK2sXlsVGrs7o%3D
    • Holmes E, Foxall PJD, Spraul M, Farrant RD, Nicholson JK, Lindon JC (1997) 750 MHz H-1 NMR spectroscopy characterisation of the complex metabolic pattern of urine from patients with inborn errors of metabolism: 2-hydroxyglutaric aciduria and maple syrup urine disease. J Pharm Biomed Anal 15:1647-1659
    • (1997) J Pharm Biomed Anal , vol.15 , pp. 1647-1659
    • Holmes, E.1    Foxall, P.J.D.2    Spraul, M.3    Farrant, R.D.4    Nicholson, J.K.5    Lindon, J.C.6
  • 7
    • 39149126712 scopus 로고    scopus 로고
    • Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts
    • 10.1038/nprot.2007.376 1:CAS:528:DC%2BD2sXhtlSlsr3E
    • Beckonert O, Keun HC, Ebbels TMD, Bundy JG, Holmes E, Lindon JC, Nicholson JK (2007) Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat Protoc 2:2692-2703
    • (2007) Nat Protoc , vol.2 , pp. 2692-2703
    • Beckonert, O.1    Keun, H.C.2    Ebbels, T.M.D.3    Bundy, J.G.4    Holmes, E.5    Lindon, J.C.6    Nicholson, J.K.7
  • 8
    • 19144371287 scopus 로고    scopus 로고
    • NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition
    • 10.1002/nbm.935 1:CAS:528:DC%2BD2MXltlCrs7o%3D
    • Bollard ME, Stanley EG, Lindon JC, Nicholson JK, Holmes E (2005) NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed 18:143-162
    • (2005) NMR Biomed , vol.18 , pp. 143-162
    • Bollard, M.E.1    Stanley, E.G.2    Lindon, J.C.3    Nicholson, J.K.4    Holmes, E.5
  • 9
    • 36649020263 scopus 로고    scopus 로고
    • Metabolomics identifies perturbations in human disorders of propionate metabolism
    • 10.1373/clinchem.2007.089011 1:CAS:528:DC%2BD2sXhtl2qt77P
    • Wikoff WR, Gangoiti JA, Barshop BA, Siuzdak G (2007) Metabolomics identifies perturbations in human disorders of propionate metabolism. Clin Chem 53:2169-2176
    • (2007) Clin Chem , vol.53 , pp. 2169-2176
    • Wikoff, W.R.1    Gangoiti, J.A.2    Barshop, B.A.3    Siuzdak, G.4
  • 10
    • 36348960223 scopus 로고    scopus 로고
    • Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: The consortium on metabonomic toxicology screening approach
    • 10.1021/pr0703021 1:CAS:528:DC%2BD2sXhtFWgu77N
    • Ebbels TMD, Keun HC, Beckonert OP, Bollard ME, Lindon JC, Holmes E, Nicholson JK (2007) Prediction and classification of drug toxicity using probabilistic modeling of temporal metabolic data: the consortium on metabonomic toxicology screening approach. J Proteome Res 6:4407-4422
    • (2007) J Proteome Res , vol.6 , pp. 4407-4422
    • Ebbels, T.M.D.1    Keun, H.C.2    Beckonert, O.P.3    Bollard, M.E.4    Lindon, J.C.5    Holmes, E.6    Nicholson, J.K.7
  • 11
    • 36349020905 scopus 로고    scopus 로고
    • COMET and the challenge of drug safety screening
    • 10.1021/pr070795+ 1:CAS:528:DC%2BD2sXht1GmtLrN
    • Nicholson J, Keun H, Ebbels T (2007) COMET and the challenge of drug safety screening. J Proteome Res 6:4098-4099
    • (2007) J Proteome Res , vol.6 , pp. 4098-4099
    • Nicholson, J.1    Keun, H.2    Ebbels, T.3
  • 12
    • 84861808541 scopus 로고    scopus 로고
    • Quantitative metabolomic profiling of serum, plasma, and urine by H-1 NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals
    • 10.1021/pr300139q 1:CAS:528:DC%2BC38XmslGru7o%3D
    • Schicho R, Shaykhutdinov R, Ngo J, Nazyrova A, Schneider C, Panaccione R, Kaplan GG, Vogel HJ, Storr M (2012) Quantitative metabolomic profiling of serum, plasma, and urine by H-1 NMR spectroscopy discriminates between patients with inflammatory bowel disease and healthy individuals. J Proteome Res 11:3344-3357
    • (2012) J Proteome Res , vol.11 , pp. 3344-3357
    • Schicho, R.1    Shaykhutdinov, R.2    Ngo, J.3    Nazyrova, A.4    Schneider, C.5    Panaccione, R.6    Kaplan, G.G.7    Vogel, H.J.8    Storr, M.9
  • 13
    • 84867250802 scopus 로고    scopus 로고
    • Application of NMR metabolomics to search for human disease biomarkers
    • 10.2174/138620712802650522 1:CAS:528:DC%2BC38XhsFGru7nL
    • Gebregiworgis T, Powers R (2012) Application of NMR metabolomics to search for human disease biomarkers. Comb Chem High Throughput Screen 15:595-610
    • (2012) Comb Chem High Throughput Screen , vol.15 , pp. 595-610
    • Gebregiworgis, T.1    Powers, R.2
  • 14
    • 33947216093 scopus 로고    scopus 로고
    • A comprehensive urinary metabolomic approach for identifying kidney cancer
    • 10.1016/j.ab.2007.01.028 1:CAS:528:DC%2BD2sXjsVWiurc%3D
    • Kind T, Tolstikov V, Fiehn O, Weiss RH (2007) A comprehensive urinary metabolomic approach for identifying kidney cancer. Anal Biochem 363:185-195
    • (2007) Anal Biochem , vol.363 , pp. 185-195
    • Kind, T.1    Tolstikov, V.2    Fiehn, O.3    Weiss, R.H.4
  • 15
    • 79954452136 scopus 로고    scopus 로고
    • Cancer biomarker discovery: Opportunities and pitfalls in analytical methods
    • 10.1002/elps.201000588 1:CAS:528:DC%2BC3MXks1Wiur0%3D
    • Issaq HJ, Waybright TJ, Veenstra TD (2011) Cancer biomarker discovery: opportunities and pitfalls in analytical methods. Electrophoresis 32:967-975
    • (2011) Electrophoresis , vol.32 , pp. 967-975
    • Issaq, H.J.1    Waybright, T.J.2    Veenstra, T.D.3
  • 16
    • 0036007687 scopus 로고    scopus 로고
    • Metabolomics - The link between genotypes and phenotypes
    • 1:CAS:528:DC%2BD38Xht1Kqtr0%3D
    • Fiehn O (2002) Metabolomics - the link between genotypes and phenotypes. Plant MolBiol 48:155-171
    • (2002) Plant MolBiol , vol.48 , pp. 155-171
    • Fiehn, O.1
  • 18
    • 83455203337 scopus 로고    scopus 로고
    • Modern analytical techniques in metabolomics analysis
    • 10.1039/c1an15605e 1:CAS:528:DC%2BC3MXhs1SisLbJ
    • Zhang AH, Sun H, Wang P, Han Y, Wang XJ (2012) Modern analytical techniques in metabolomics analysis. Analyst 137:293-300
    • (2012) Analyst , vol.137 , pp. 293-300
    • Zhang, A.H.1    Sun, H.2    Wang, P.3    Han, Y.4    Wang, X.J.5
  • 19
    • 84865607215 scopus 로고    scopus 로고
    • Quantitative NMR for bioanalysis and metabolomics
    • 10.1007/s00216-012-6188-z 1:CAS:528:DC%2BC38XpvVSnt7Y%3D
    • Barding G, Salditos R, Larive C (2012) Quantitative NMR for bioanalysis and metabolomics. Anal Bioanal Chem 404:1165-1179
    • (2012) Anal Bioanal Chem , vol.404 , pp. 1165-1179
    • Barding, G.1    Salditos, R.2    Larive, C.3
  • 20
    • 0017764472 scopus 로고
    • Human erythrocyte metabolism studies by H-1 spin-echo NMR
    • 10.1016/0014-5793(77)80875-2 1:CAS:528:DyaE1cXjsVSmtA%3D%3D
    • Brown FF, Campbell ID, Kuchel PW, Rabenstein DC (1977) Human erythrocyte metabolism studies by H-1 spin-echo NMR. FEBS Lett 82:12-16
    • (1977) FEBS Lett , vol.82 , pp. 12-16
    • Brown, F.F.1    Campbell, I.D.2    Kuchel, P.W.3    Rabenstein, D.C.4
  • 21
    • 0021403120 scopus 로고
    • Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine
    • 1:CAS:528:DyaL2cXhslSqurc%3D
    • Bales JR, Higham DP, Howe I, Nicholson JK, Sadler PJ (1984) Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Clin Chem 30:426-432
    • (1984) Clin Chem , vol.30 , pp. 426-432
    • Bales, J.R.1    Higham, D.P.2    Howe, I.3    Nicholson, J.K.4    Sadler, P.J.5
  • 23
    • 77749324192 scopus 로고    scopus 로고
    • Evaluation of full-resolution J-resolved H-1 NMR projections of biofluids for metabonomics information retrieval and biomarker identification
    • 10.1021/ac902443k 1:CAS:528:DC%2BC3cXhsVyhsLo%3D
    • Fonville JM, Maher AD, Coen M, Holmes E, Lindon JC, Nicholson JK (2010) Evaluation of full-resolution J-resolved H-1 NMR projections of biofluids for metabonomics information retrieval and biomarker identification. Anal Chem 82:1811-1821
    • (2010) Anal Chem , vol.82 , pp. 1811-1821
    • Fonville, J.M.1    Maher, A.D.2    Coen, M.3    Holmes, E.4    Lindon, J.C.5    Nicholson, J.K.6
  • 24
    • 33645663178 scopus 로고    scopus 로고
    • Scaling and normalization effects in NMR spectroscopic metabonomic data sets
    • 10.1021/ac0519312 1:CAS:528:DC%2BD28XhsFartL0%3D
    • Craig A, Cloareo O, Holmes E, Nicholson JK, Lindon JC (2006) Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal Chem 78:2262-2267
    • (2006) Anal Chem , vol.78 , pp. 2262-2267
    • Craig, A.1    Cloareo, O.2    Holmes, E.3    Nicholson, J.K.4    Lindon, J.C.5
  • 25
    • 33745728718 scopus 로고    scopus 로고
    • Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in H-1 NMR metabonomics
    • 10.1021/ac051632c 1:CAS:528:DC%2BD28XltVCgtro%3D
    • Dieterle F, Ross A, Schlotterbeck G, Senn H (2006) Probabilistic quotient normalization as robust method to account for dilution of complex biological mixtures. Application in H-1 NMR metabonomics. Anal Chem 78:4281-4290
    • (2006) Anal Chem , vol.78 , pp. 4281-4290
    • Dieterle, F.1    Ross, A.2    Schlotterbeck, G.3    Senn, H.4
  • 26
    • 0037228105 scopus 로고    scopus 로고
    • Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey
    • 10.1053/ajkd.2003.50007
    • Coresh J, Astor BC, Greene T, Eknoyan G, Levey AS (2003) Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis 41:1-12
    • (2003) Am J Kidney Dis , vol.41 , pp. 1-12
    • Coresh, J.1    Astor, B.C.2    Greene, T.3    Eknoyan, G.4    Levey, A.S.5
  • 27
    • 0000325341 scopus 로고
    • On lines and planes of closest fit to systems of points in space
    • Pearson K (1901) On lines and planes of closest fit to systems of points in space. Philos Mag 2:559-572
    • (1901) Philos Mag , vol.2 , pp. 559-572
    • Pearson, K.1
  • 28
    • 0036085968 scopus 로고    scopus 로고
    • O2-PLS for qualitative and quantitative analysis in multivariate calibration
    • 10.1002/cem.724 1:CAS:528:DC%2BD38XltVWmsL0%3D
    • Trygg J (2002) O2-PLS for qualitative and quantitative analysis in multivariate calibration. J Chemom 16:283-293
    • (2002) J Chemom , vol.16 , pp. 283-293
    • Trygg, J.1
  • 29
    • 0036083139 scopus 로고    scopus 로고
    • Orthogonal projections to latent structures (O-PLS)
    • 10.1002/cem.695 1:CAS:528:DC%2BD38XitFClu7c%3D
    • Trygg J, Wold S (2002) Orthogonal projections to latent structures (O-PLS). J Chemom 16:119-128
    • (2002) J Chemom , vol.16 , pp. 119-128
    • Trygg, J.1    Wold, S.2
  • 30
    • 33846240326 scopus 로고    scopus 로고
    • Statistical strategies for avoiding false discoveries in metabolomics and related experiments
    • 10.1007/s11306-006-0037-z 1:CAS:528:DC%2BD2sXhsVWktL4%3D
    • Broadhurst DI, Kell DB (2006) Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics 2:171-196
    • (2006) Metabolomics , vol.2 , pp. 171-196
    • Broadhurst, D.I.1    Kell, D.B.2
  • 31
    • 79958186715 scopus 로고    scopus 로고
    • A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease
    • 10.1021/pr200047c 1:CAS:528:DC%2BC3MXlvFKqsbs%3D
    • Li H, Wang L, Yan XZ, Liu QJ, Yu CH, Wei HD, Li YM, Zhang XM, He FC, Jiang Y (2011) A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease. J Proteome Res 10:2797-2806
    • (2011) J Proteome Res , vol.10 , pp. 2797-2806
    • Li, H.1    Wang, L.2    Yan, X.Z.3    Liu, Q.J.4    Yu, C.H.5    Wei, H.D.6    Li, Y.M.7    Zhang, X.M.8    He, F.C.9    Jiang, Y.10
  • 32
    • 80054910708 scopus 로고    scopus 로고
    • Analysis of complex mixtures using high-resolution nuclear magnetic resonance spectroscopy and chemometrics
    • 10.1016/j.pnmrs.2011.04.003 1:CAS:528:DC%2BC3MXhtlGns7rN
    • McKenzie JS, Donarski JA, Wilson JC, Charlton AJ (2011) Analysis of complex mixtures using high-resolution nuclear magnetic resonance spectroscopy and chemometrics. Prog Nucl Magn Reson Spectrosc 59:336-359
    • (2011) Prog Nucl Magn Reson Spectrosc , vol.59 , pp. 336-359
    • McKenzie, J.S.1    Donarski, J.A.2    Wilson, J.C.3    Charlton, A.J.4
  • 33
    • 68949110561 scopus 로고    scopus 로고
    • Metabolic profiling of Parkinson's disease: Evidence of biomarker from gene expression analysis and rapid neural network detection
    • 10.1186/1423-0127-16-63
    • Ahmed S, Santosh W, Kumar S, Christlet HTT (2009) Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection. J Biomed Sci 16:12
    • (2009) J Biomed Sci , vol.16 , pp. 12
    • Ahmed, S.1    Santosh, W.2    Kumar, S.3    Christlet, H.T.T.4
  • 34
    • 44149120238 scopus 로고    scopus 로고
    • Non-targeted detection of chemical contamination in carbonated soft drinks using NMR spectroscopy, variable selection and chemometrics
    • 10.1016/j.aca.2008.04.050 1:CAS:528:DC%2BD1cXms1yjurs%3D
    • Charlton AJ, Robb P, Donarski JA, Godward J (2008) Non-targeted detection of chemical contamination in carbonated soft drinks using NMR spectroscopy, variable selection and chemometrics. Anal Chim Acta 618:196-203
    • (2008) Anal Chim Acta , vol.618 , pp. 196-203
    • Charlton, A.J.1    Robb, P.2    Donarski, J.A.3    Godward, J.4
  • 35
    • 80054710464 scopus 로고    scopus 로고
    • Ratio analysis nuclear magnetic resonance spectroscopy for selective metabolite identification in complex samples
    • 10.1021/ac201625f 1:CAS:528:DC%2BC3MXht1aisbnL
    • Wei S, Zhang J, Liu L, Ye T, Gowda GAN, Tayyari F, Raftery D (2011) Ratio analysis nuclear magnetic resonance spectroscopy for selective metabolite identification in complex samples. Anal Chem 83:7616-7623
    • (2011) Anal Chem , vol.83 , pp. 7616-7623
    • Wei, S.1    Zhang, J.2    Liu, L.3    Ye, T.4    Gowda, G.A.N.5    Tayyari, F.6    Raftery, D.7
  • 36
    • 79960698472 scopus 로고
    • Water suppression that works. Excitation sculpting using arbitrary waveforms and pulsed field gradients
    • 10.1006/jmra.1995.1047 1:CAS:528:DyaK2MXjs1Wmsb0%3D
    • Hwang TL, Shaka AJ (1995) Water suppression that works. Excitation sculpting using arbitrary waveforms and pulsed field gradients. J Magn Reson Ser A 112:275-279
    • (1995) J Magn Reson ser A , vol.112 , pp. 275-279
    • Hwang, T.L.1    Shaka, A.J.2
  • 39
    • 0038365368 scopus 로고    scopus 로고
    • Analysis of microarray data using Z score transformation
    • 10.1016/S1525-1578(10)60455-2 1:CAS:528:DC%2BD3sXjvVSgtLc%3D
    • Cheadle C, Vawter MP, Freed WJ, Becker KG (2003) Analysis of microarray data using Z score transformation. J Mol Diag 5:73-81
    • (2003) J Mol Diag , vol.5 , pp. 73-81
    • Cheadle, C.1    Vawter, M.P.2    Freed, W.J.3    Becker, K.G.4
  • 40
    • 0026526366 scopus 로고
    • Liquid-chromatography coupled with high-field proton NMR for profiling human urine for endogenous compounds and drug metabolites
    • 10.1016/0731-7085(92)80086-3 1:CAS:528:DyaK3sXjt1Cntg%3D%3D
    • Spraul M, Hofmann M, Dvortsak P, Nicholson JK, Wilson ID (1992) Liquid-chromatography coupled with high-field proton NMR for profiling human urine for endogenous compounds and drug metabolites. J Pharm Biomed Anal 10:601-605
    • (1992) J Pharm Biomed Anal , vol.10 , pp. 601-605
    • Spraul, M.1    Hofmann, M.2    Dvortsak, P.3    Nicholson, J.K.4    Wilson, I.D.5
  • 41
    • 0023628652 scopus 로고
    • Solid-phase extraction chromatography and nuclear magnetic resonance spectrometry for the identification and isolation of drug metabolites in urine
    • 10.1021/ac00150a025 1:CAS:528:DyaL2sXlvFShs7c%3D
    • Wilson ID, Nicholson JK (1987) Solid-phase extraction chromatography and nuclear magnetic resonance spectrometry for the identification and isolation of drug metabolites in urine. Anal Chem 59:2830-2832
    • (1987) Anal Chem , vol.59 , pp. 2830-2832
    • Wilson, I.D.1    Nicholson, J.K.2
  • 42
    • 0023887138 scopus 로고
    • Solid-phase extraction chromatography and NMR-spectroscopy (SPEC-NMR) for the rapid identification of drug metabolites in urine
    • 10.1016/0731-7085(88)80041-4 1:CAS:528:DyaL1cXktFKnur0%3D
    • Wilson ID, Nicholson JK (1988) Solid-phase extraction chromatography and NMR-spectroscopy (SPEC-NMR) for the rapid identification of drug metabolites in urine. J Pharm Biomed Anal 6:151-165
    • (1988) J Pharm Biomed Anal , vol.6 , pp. 151-165
    • Wilson, I.D.1    Nicholson, J.K.2
  • 43
    • 36049042571 scopus 로고    scopus 로고
    • Variation of metabolites in normal human urine
    • 10.1007/s11306-007-0091-1 1:CAS:528:DC%2BD2sXhsVals7rF
    • Saude EJ, Adamko D, Rowe BH, Marrie T, Sykes BD (2007) Variation of metabolites in normal human urine. Metabolomics 3:439-451
    • (2007) Metabolomics , vol.3 , pp. 439-451
    • Saude, E.J.1    Adamko, D.2    Rowe, B.H.3    Marrie, T.4    Sykes, B.D.5


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