Treatment for mild cognitive impairment: Systematic review

British Journal of Psychiatry

Volumn 203, Issue 4, 2013, Pages 255-264

  Cooper, Claudia ^a   Li, Ryan ^a   Lyketsos, Constantine ^b   Livingston, Gill ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; DOCOSAHEXAENOIC ACID; DONEPEZIL; GALANTAMINE; GINKGO BILOBA EXTRACT; ICOSAPENTAENOIC ACID; NICOTINE; NONSTEROID ANTIINFLAMMATORY AGENT; PIRIBEDIL; PLACEBO; RIVASTIGMINE; ROFECOXIB; VITAMIN B GROUP;

ATTENTION; DEMENTIA; HUMAN; MILD COGNITIVE IMPAIRMENT; PLACEBO EFFECT; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SYSTEMATIC REVIEW; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHOLINESTERASE INHIBITORS; COGNITIVE THERAPY; DOPAMINE AGONISTS; DRUGS, CHINESE HERBAL; EXERCISE THERAPY; FATTY ACIDS, OMEGA-3; GINKGO BILOBA; HUMANS; MILD COGNITIVE IMPAIRMENT; NICOTINE; NICOTINIC AGONISTS; PHYTOTHERAPY; PIRIBEDIL; PSYCHOTHERAPY, GROUP; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; THERAPY, COMPUTER-ASSISTED; TREATMENT OUTCOME; VITAMINS;

EID: 84885402153     PISSN: 00071250     EISSN: 14721465     Source Type: Journal    
DOI: 10.1192/bjp.bp.113.127811     Document Type: Review

References (61)

1. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256: 183-94. (Pubitemid 39222988)
2. Lopez OL, Kuller LH, Becker JT, Dulberg C, Sweet RA, Gach HM et al. Incidence of dementia in mild cognitive impairment in the cardiovascular health study cognition study. Arch Neurol 2007; 64: 416-20. (Pubitemid 46425698)
3. Tschanz JT, Welsh-Bohmer KA, Lyketsos CG, Corcoran C, Green RC, Hayden K, et al. Conversion to dementia from mild cognitive disorder - the Cache County Study. Neurology 2006; 67: 229-34. (Pubitemid 44305404)
4. National Institute for Health and Clinical Excellence. Dementia: Supporting People with Dementia and their Carers in Health and Social Care. Clinical Guideline 42. NICE, 2006.
5. Jorm AF, Korten AE, Henderson AS. The prevalence of dementia - a quantitative integration of the literature. Acta Psychiatr Scand 1987; 76: 465-79. (Pubitemid 17164786)
6. Raschetti R, Albanese E, Vanacore N, Maggini M. Cholinesterase inhibitors in mild cognitive impairment: a systematic review of randomised trials. PLoS Med 2007; 4: e338.
7. Birks J, Flicker L. Donepezil for mild cognitive impairment. Cochrane Database Syst Rev 2006; 3: CD006104.
8. Loy C, Schneider L. Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev 2006; 1: CD001747.
9. Martin M, Clare L, Altgassen AM, Cameron MH, Zehnder F. Cognition-based interventions for healthy older people and people with mild cognitive impairment. Cochrane Database Syst Rev 2011; 1: CD006220.
10. Gates NJ, Sachdev PS, Fiatarone Singh MA, Valenzuela M. Cognitive and memory training in adults at risk of dementia: a systematic review. BMC Geriatr 2011; 11: 55.
11. Jean L, Bergeron ME, Thivierge S, Simard M. Cognitive intervention programs for individuals with mild cognitive impairment: systematic review of the literature. Am J Geriatr Psychiatry 2010; 18: 281-96.
12. Simon SS, Yokomizo JE, Bottino CM. Cognitive intervention in amnestic mild cognitive impairment: a systematic review. Neurosci Biobehav Rev 2012; 36: 1163-78.
13. Stott J, Spector A. A review of the effectiveness of memory interventions in mild cognitive impairment (MCI). Int Psychogeriatr 2011; 23: 526-38.
14. Unverzagt FW, Kasten L, Johnson KE, Rebok GW, Marsiske M, Koepke KM, et al. Effect of memory impairment on training outcomes in ACTIVE. J Internat Neuropsychol Soc 2007; 13: 953-60. (Pubitemid 47617546)
15. Doody RS, Ferris SH, Salloway S, Sun Y, Goldman R, Watkins WE, et al. Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology 2009; 72: 1555-61.
16. StatsDirect. Stats Direct Statistical Software. StatsDirect, 2012.
17. Baker LD, Frank LL, Foster-Schubert K, Green PS, Wilkinson CW, McTiernan A, et al. Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Arch Neurol 2010; 67: 71-9.
18. Barnes DE, Yaffe K, Belfor N, Jagust WJ, DeCarli C, Reed BR, et al. Computerbased cognitive training for mild cognitive impairment: results from a pilot randomized, controlled trial. Alzheimer Dis Assoc Disord 2009; 23: 205-10.
19. Buschert VC, Friese U, Teipel SJ, Schneider P, Merensky W, Rujescu D, et al. Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study. J Alzheimers Dis 2011; 25: 679-94.
20. Kinsella GJ, Mullaly E, Rand E, Ong B, Burton C, Price S, et al. Early intervention for mild cognitive impairment: a randomised controlled trial. J Neurol Neurosurg Psychiatry 2009; 80: 730-6.
21. Newhouse P, Kellar K, Aisen P, White H, Wesnes K, Coderre E, et al. Nicotine treatment of mild cognitive impairment: a 6-month double-blind pilot clinical trial. Neurology 2012; 78: 91-101.
22. Koontz J, Baskys A. Effects of galantamine on working memory and global functioning in patients with mild cognitive impairment: a double-blind placebo-controlled study. Am J Alzheimers Dis Other Demen 2005; 20: 295-302. (Pubitemid 41502371)
23. Nagaraja D, Jayashree S. Randomized study of the dopamine receptor agonist piribedil in the treatment of mild cognitive impairment. Am J Psychiatry 2001; 158: 1517-9. (Pubitemid 32847257)
24. Troyer AK, Murphy KJ, Anderson ND, Moscovitch M, Craik FI. Changing everyday memory behaviour in amnestic mild cognitive impairment: a randomised controlled trial. Neuropsychol Rehabil 2008; 18: 65-88. (Pubitemid 350223208)
25. Zhao MX, Dong ZH, Yu ZH, Xiao SY, Li YM. Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: a randomized controlled trial [in Chinese]. Zhong Xi Yi Jie He Xue Bao 2012; 10: 628-34.
26. Busse AL, Filho JW, Magaldi RM, Coelho VA, Melo AC, Betoni RA, et al. Effects of resistance training exercise on cognitive performance in elderly individuals with memory impairment: results of a controlled trial. Einstein 2008; 6: 402-7.
27. Pelton GH, Harper OL, Tabert MH, Sackeim HA, Scarmeas N, Roose SP, et al. Randomized double-blind placebo-controlled donepezil augmentation in antidepressant-treated elderly patients with depression and cognitive impairment: a pilot study. Int J Geriatr Psychiatry 2008; 23: 670-6.
28. Li H, Yao MJ, Zhao WM, Guan J, Cai LL, Cui L. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment [in Chinese]. Zhong Xi Yi Jie He Xue Bao 2008; 6: 25-31. (Pubitemid 351166461)
29. Chiu CC, Su KP, Cheng TC, Liu HC, Chang CJ, Dewey ME, et al. The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1538-44.
30. de Jager CA, Oulhaj A, Jacoby R, Refsum H, Smith AD. Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. Int J Geriatr Psychiatry 2012; 27: 592-600.
31. Feldman HH, Ferris S, Winblad B, Sfikas N, Mancione L, He Y, et al. Effect of rivastigmine on delay to diagnosis of Alzheimer's disease from mild cognitive impairment: the InDDEx study. Lancet Neurol 2007; 6: 501-12. (Pubitemid 46738627)
32. Krikorian R, Nash TA, Shidler MD, Shukitt-Hale B, Joseph JA. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr 2010; 103: 730-4.
33. Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, et al. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind placebo-controlled study. J Med Food 2011; 14: 334-43.
34. Sinn N, Milte CM, Street SJ, Buckley JD, Coates AM, Petkov J, et al. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. Br J Nutr 2012; 107: 1682-93.
35. DeKosky ST, Williamson JD, Fitzpatrick AL, Kronmal RA, Ives DG, Saxton JA, et al. Ginkgo biloba for prevention of dementia: a randomized controlled trial. JAMA 2008; 300: 2253-62.
36. Fu H, Wang XM, Liu GX. Effects of modified Wuzi Yanzong Granule on memory ability and volume of hippocampus measured by MRI in patients with mild cognitive impairment [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2006; 26: 1066-9.
37. Tian JZ, Zhu AH, Zhong J. A follow-up study on a randomized, single-blind control of King's Brain pills in treatment of memory disorder in elderly people with MCI in a Beijing community [in Chinese]. Zhongguo Zhong Yao Za Zhi 2003; 28: 987-91.
38. van Uffelen JG, Chinapaw MJ, van MW, Hopman-Rock M. Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial. Br J Sports Med 2008; 42: 344-51. (Pubitemid 351702680)
39. Luijpen MW, Swaab DF, Sergeant JA, Scherder EJ. Effects of transcutaneous electrical nerve stimulation (TENS) on self-efficacy and mood in elderly with mild cognitive impairment. Neurorehabil Neural Repair 2004; 18: 166-75.
40. Rondanelli M, Opizzi A, Faliva M, Mozzoni M, Antoniello N, Cazzola R, et al. Effects of a diet integration with an oily emulsion of DHA-phospholipids containing melatonin and tryptophan in elderly patients suffering from mild cognitive impairment. Nutr Neurosci 2012; 15: 46-54.
41. Scherder EJ, Van PJ, Deijen JB, Van Der Knokke S, Orlebeke JF, Burgers I, et al. Physical activity and executive functions in the elderly with mild cognitive impairment. Aging Ment Health 2005; 9: 272-80. (Pubitemid 40780419)
42. Suzuki T, Shimada H, Makizako H, Doi T, Yoshida D, Tsutsumimoto K, et al. Effects of multicomponent exercise on cognitive function in older adults with amnestic mild cognitive impairment: a randomized controlled trial. BMC Neurology 2012; 12: 128.
43. Mowla A, Mosavinasab M, Pani A. Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial. J Clin Psychopharmacol 2007; 27: 67-70. (Pubitemid 46105768)
44. Gomez-Isla T, Blesa R, Boada M, Clarimon J, Del ST, Domenech G, et al. A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study. Alzheimer Dis Assoc Disord 2008; 22: 21-9. (Pubitemid 351651394)
45. Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 2005; 352: 2379-88. (Pubitemid 40958434)
46. Rapp S, Brenes G, Marsh AP. Memory enhancement training for older adults with mild cognitive impairment: a preliminary study. Aging Ment Health 2002; 6: 5-11. (Pubitemid 34146143)
47. Rozzini L, Costardi D, Chilovi BV, Franzoni S, Trabucchi M, Padovani A. Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. Int J Geriatr Psychiatry 2007; 22: 356-60. (Pubitemid 46680847)
48. Salloway S, Ferris S, Kluger A, Goldman R, Griesing T, Kumar D, et al. Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial. Neurology 2004; 63: 651-7. (Pubitemid 39100820)
49. Thal LJ, Ferris SH, Kirby L, Block GA, Lines CR, Yuen E, et al. A randomized, double-blind, study of rofecoxib in patients with mild cognitive impairment. Neuropsychopharmacology 2005; 30: 1204-15. (Pubitemid 40720980)
50. Zhou RQ, Lin SM, Yuan Q. Clinical study on effect of Shenyin Oral Liquid in treating mild cognitive impairment [in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi 2007; 27: 793-5.
51. Winblad B, Gauthier S, Scinto L, Feldman H, Wilcock GK, Truyen L et al. Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology 2008; 70: 2024-35.
52. Ferris S, Schneider L, Farmer M, Kay G, Crook T. A double-blind, placebocontrolled trial of memantine in age-associated memory impairment (memantine in AAMI). Int J Geriatr Psychiatry 2007; 22: 448-55. (Pubitemid 46831689)
53. Jean L, Simard M, Wiederkehr S, Bergeron ME, Turgeon Y, Hudon C, et al. Efficacy of a cognitive training programme for mild cognitive impairment: results of a randomised controlled study. Neuropsychol Rehabil 2010; 20: 377-405.
54. van Uffelen JG, Chin APMJ, Hopman-Rock M, van Mechelen W. The effect of walking and vitamin B supplementation on quality of life in communitydwelling adults with mild cognitive impairment: a randomized, controlled trial. Qual Life Res 2007; 16: 1137-46. (Pubitemid 47357721)
55. Finn M, McDonald S. Computerised cognitive training for older persons with mild cognitive impairment: a pilot study using a randomised controlled trial design. Brain Impair 2011; 12: 187-99.
56. Birks J, Evans JG. Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev 2009; 1: CD003120.
57. Snitz BE, O'Meara ES, Carlson MC, Arnold AM, Ives DG, Rapp SR, et al. Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. JAMA 2009; 302: 2663-70.
58. Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, et al. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001; 414: 212-6. (Pubitemid 33051236)
59. Forlenza OV, Diniz BS, Radanovic M, Santos FS, Talib LL, Gattaz WF. Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry 2011; 198: 351-6.
60. Busse A, Angermeyer MC, Riedel-Heller SG. Progression of mild cognitive impairment to dementia: a challenge to current thinking. Br J Psychiatry 2006; 189: 399-404. (Pubitemid 44683170)
61. Schneider LS. The potential and limits for clinical trials for early Alzheimer's disease and some recommendations. J Nutr Health Aging 2010; 14: 295-8.