Computerised cognitive training for older persons with mild cognitive impairment: A pilot study using a randomised controlled trial design

Brain Impairment

Volumn 12, Issue 3, 2011, Pages 187-199

  Finn, Maurice ^a   McDonald, Skye ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

Aged; Cognition; Cognitive training; Human; Mild cognitive impairment; Randomised controlled trial

Indexed keywords

ADULT; AGED; ARTICLE; ATTENTION; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; COGNITIVE REHABILITATION; COMPUTER AIDED DESIGN; CONTROLLED STUDY; EXECUTIVE FUNCTION; FEMALE; HUMAN; MALE; MEMORY; NEUROPSYCHOLOGY; PERCEPTION; PERFORMANCE; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; STUDY DESIGN; VISUAL MEMORY;

EID: 84555219903     PISSN: 14439646     EISSN: 18395252     Source Type: Journal    
DOI: 10.1375/brim.12.3.187     Document Type: Article

References (47)

1. Antony, M.M., Bieling, P.J., Cox, B.J., Enns, M.W. & Swinson, R.P. (1998). Psychometric properties of the 42-item and 21-item versions of the Depression Anxiety Stress Scale in clinical groups and a community sample. Psychological Assessment, 10(2) 176-181.
2. Ball, K., Berch, D.B., Helmers, K.F., Jobe, J.B., Leveck, M.D., Marsiske, M.,... Willis, S.L. (2002). Effects of cognitive training interventions with older adults. Journal of the American Medical Association, 288(18), 2271-2281
3. Barnes, D., Yaffe, K., Belfor, N., Reed, B., Jagust, W., DeCarli,... Kraemer, J.H. (2009). Computer-based cognitive training for mild cognitive impairment: Results from a pilot randomized controlled trial. Alzheimer Disease and Associated Disorders, 23(3), 205-210.
4. Belleville, S. (2008). Cognitive training for persons with mild cognitive impairment. International Psychogeriatrics, 20, 57-66.
5. Belleville, S., Gilbert, B., Fontaine, F., Gagnon, L., Menard, E., & Gauthier, S. (2006). Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: Evidence from a cognitive intervention program. Dementia and Geriatric Cognitive Disorders, 22, 486-499.
6. Bennett, D.A., Wilson, R.S., Schneider, J.A., Evans, D.A., Beckett, L.A., Aggarwal, N.T.,... Bach, J. (2002) Natural history of mild cognitive impairment in older persons. Neurology, 59(2), 198-205.
7. Billings, L.M., Green, K.N., McGraugh, J.L., & LaFerla, F.M. (2007). Learning decreases A *56 Tau pathology and ameliorates behavioral decline in 3xTg-AD mice. The Journal of Neuroscience, 27(4), 751-761.
8. Birks, J., & Flicker, L. (2006). Donezepil for mild cognitive impairment. Cochrane Database of Systematic Reviews, Iss. 3. Art. No. CD006104. doi: 10.1002/14651858.CD006104.
9. Cambridge NeuropsychologicalTest Automated Battery (CANTAB). (2005). CANTAB Test administration guide and test kit. (2005). Cambridge Cognition.
10. Cipriani, G., Bianchetti, A., & Trabucchi, M. (2006). Outcomes of a computer-based cognitive rehabilitation program on Alzheimer's disease patients compared with those on patients affected by mild cognitive impairment. Archives of Gerontology and Geriatrics, 43, 327-335.
11. Clare, L., & Woods, R.T. (2003). Cognitive rehabilitation and cognitive training for early-stage Alzheimer's disease and vascular dementia. Cochrane Database of Systematic Reviews, Iss. 4. Art. No.: CD003260.
12. Dinse, H.R. (2006). Cortical reorganization in the aging brain. Progress in Brain Research, 157, 57-80
13. Feldman, H.H., & Jacova, C. (2005). Mild cognitive impairment. American Journal of Psychiatry, 13(8), 645-655.
14. Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
15. Foreman, N., Stanton-Fraser, D., Wilson, P.N., Duffy, H., & Parnell, R. (2005). Transfer of spatial knowledge to a two-level shopping mall in older people, following virtual exploration. Environment and Behavior, 37(2), 275-292.
16. Gilewski, M.J., Zelinski, E.M., & Schaie, K.W. (1990). The Memory Functioning Questionnaire for assessment of memory complaints in adulthood and old age. Psychology & Aging, 5, 482-490.
17. Jankowsky, J.L., Melnikova, T., Fadale, D.J., Xu, G.M., Slunt, H.H., Gonzales, V.,... Savoneko, A.V. (2005). Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience, 25(21), 5217-5224.
18. Kemperman, G., Gast, D., & Gage, F.H. (2002). Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Annals of Neurology, 52,135-143.
19. Kesler, S.R., Lacayo, N.J., & Jo, B. (2011). A pilot study of an online cognitive rehabilitation program for executive function skills in children with cancerrelated brain injury. Brain Injury, 25(1) 101-112.
20. Lachman, M.E. Bandura, M, Weaver, S.L., & Elliott, E. (1995). Assessing memory control beliefs: the memory controllability inventory. Aging and Cognition, 2, 67-84.
21. Lazarov, O., Robinson, J., Tang, YP. Hairston, I.S., Korade-Mirnics, Lee, V.M.,... Sisodia, S.S. (2005). Environmental enrichment reduces A-beta levels and amyloid deposition in transgenic mice. Cell, 120, 701-713
22. Lovibond, S.H. & Lovibond, P.F. (1995). Manual for the Depression Anxiety Stress Scales. (2nd ed.). Sydney, Australia: Psychology Foundation.
23. McGurk, S.R., Twamley, E.W., Sitzer, D.I., McHugo, G.J. & Mueser, K.T. (2006). A meta-analysis of cognitive remediation in schizophrenia. American Journal of Psychiatry, 164, 1791-1802.
24. McNab, F., Varonne, A., Farde, L., Jucaite, A., Bystritsky, P., Forssberg, H. & Klingberg, T. (2009). Changes in cortical dopamine D1 binding associated with cognitive training. Science, 323(5915), 800-802.
25. Mahncke, H.W., Connor, B.B., Appelman, J. Ahsanuddin, O.N., Hardy, J.L., Wood, R.A.,... Merzenich, M.M.(2006). Brain plasticity and functional losses in the aged: scientific bases for a novel intervention. Progress in Brain Research, 157, 81-109.
26. Nyberg, L., Sandblom, J., Jones, S., Stigsdotter, A., Petersson, K.M., Ingvar, M., & Backman, L. (2003): Neural correlates of training-related memory improvement in adulthood and aging. Proceedings of the National Academy of Sciences USA, 100, 13728-13733.
27. Olesen, P.J., Westerberg, H., & Klingberg, T. (2004). Increased prefrontal and parietal activity after training of working memory. Nature Neuroscience, 7, 75-79.
28. Owen, A.M., Roberts, A.C., Polkey, C.E., Sahakian, B.J., & Robbins T.W. (1991). Extra-dimensional versus intra-dimensional set shifting performance following frontal lobe lesions, temporal lobe lesions or amygdalo-hippocampectomy in man. Neuropsychologia, 29, 993-1006.
29. Owen, A.M., Sahakian, B.J., Semple, J., Polkey, C.E., & Robbins T.W. (1995). Visuospatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe excisions or amygdalohippocampectomy in man. Neuropsychologia, 33, 1-24.
30. Owen, A.M., Sahakian, B.J., Semple, J., Polkey, C.E., & Robbins T.W. (1996). Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Brain, 119, 1597-1615.
31. Papp, K.V., Walsh, S.J., & Snyder, P.J. (2009). Immediate and delayed effects of cognitive interventions in healthy elderly: A review of the current literature and future directions. Alzheimer's and Dementia, 5, 50-60.
32. Petersen, R.C., Smith, G.E., Waring, S.C., Ivnik, R.J., Tangalos, E.G., & Kokmen, E. (1999). Mild cognitive impairment: Clinical characterization and outcome. Archives of Neurology, 56, 303-308.
33. Petersen, R.C., Thomas, R.G., Grundman, M., Bennett, D.B., Doody, R. & Ferris, S, Thal, L.J. (2005). Vitamin E and Donepezil for the treatment of mild cognitive impairment. New England Journal of Medicine, 352:2379-2389
34. Rapp, S., Brenes, G. & Marsh, A.P. (2002). Memory enhancement training for older adults with mild cognitive impairment. Aging & Mental Health, 6(1), 5-11.
35. Robbins, T.W., Elliott, R., & Sahakian, B.J. (1996). Neuropsychology - dementia and affective disorders. British Medical Bulletin, 52(3), 627-643.
36. Rozzini, L., Costardi, D., Vicini Chilovi, B., & Franzoni, S. (2007). Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors. International Journal of Geriatric Psychiatry, 22, 356-360.
37. Sahakian, B., Jones, G., Levy, R., Gray, J., & Warburton, D. (1989). The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer's type. The British Journal of Psychiatry, 154, 797-800.
38. Salthouse, T.A. (1996). The processing speed theory of adult age differences in cognition. Psychological Review, 103(3), 403-428.
39. Schuff, N., & Zhu, X.P. (2007). Imaging of mild cognitive impairment and early dementia. The British Journal of Radiology, 80, S109-S114.
40. Small, G.W., Rabins, P.V., Barry, P.P., Bucholtz, N.S., DeKosky, S.T., Ferris S.H., Tune, L.E. (1997). Diagnosis and treatment of Alzheimer disease and related disorders: Consensus statement of the American Association of Geriatric Psychiatry, the Alzheimer's Association and the American Geriatric Society. Journal of the American Medical Association, 278, 1363-1371.
41. Talassi, E., Guerreschi, M., Feriani, M., & Fedi, V. (2007). Effectiveness of a cognitive rehabilitation program in mild dementia and mild cognitive impairment: A case control study. Archives of Gerontology and Geriatrics, 44(Suppl.1) 391-399.
42. Unverzagt, F.W., Kasten, L., Johnston, K.E., Rebok, G.W., Marsiske, M., Koepke, K.M., Tennstedt, S.L. (2007). Effect of memory impairment on training outcomes in ACTIVE. Journal of the International Neuropsychological Society, 13, 953-960.
43. Valenzuela, M.J., Breakspear, M., & Sachdev, P. (2007). Complex mental activity and the aging brain: Molecular, cellular and cortical network mechanisms. Brain Research Reviews, 56, 198-213.
44. Valenzuela, M.J., Jones, M., Wen, W., Rae, C., Graham, S., Shnier, R., & Sachdev, P. (2003). Memory training alters hippocampal neurochemistry in healthy elderly. Neuroreport, 14(10),1333-1337
45. Willis, S.L., Tennstedt, S.L., Marsiske, M., Ball, K., Elias, J., Koepke, K.M.,... Wright E. (2006). Long term effects of cognitive training on everyday functional outcomes in older adults. Journal of the American Medical Association, 296(23), 2805-2814.
46. Winblad, B.I., Palmer, K., Kivipelto, M. Jelic, V., Fratiglioni, L., Wahlund, L.O.,... Petersen, R.C. (2004). Mild cognitive impairment - beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment. Journal of Internal Medicine, 256(3), 240-246.
47. Zelinski, E.M., Gilewski, M.J., & Anthony-Bergstone, C.R. (1990). Memory Functioning Questionnaire: Concurrent validity with memory performance and self-reported memory failures. Psychology and Aging, 5, 388-399.