Regioselective hydroxylation of C12-C15 fatty acids with fluorinated substituents by cytochrome P450 BM3

Chemistry - A European Journal

Volumn 19, Issue 41, 2013, Pages 13680-13691

  Chiang, Chih Hsiang ^a,b   Ramu, Ravirala ^a   Tu, Yi Jung ^a,c   Yang, Chung Ling ^a,d   Ng, Kok Yaoh ^a   Luo, Wen I ^a   Chen, Charles H ^a,e   Lu, Yu Ying ^a   Liu, Chen Lun ^f   Yu, Steve S F ^a,b  

^a INSTITUTE OF CHEMISTRY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c Taiwan Intl Grad Prog Computational Linguistics and Chinese Language Processing (TIGP CLCLP)   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e Michigan State University   (United States)

^f NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

C H activation; cytochrome P450; enzyme catalysis; fluorinated substituents; van der Waals interactions

Indexed keywords

C-H ACTIVATION; CYTOCHROME P450; ENZYME CATALYSIS; FLUORINATED SUBSTITUENTS; VAN DER WAALS INTERACTIONS;

ACTIVATION ANALYSIS; ACTIVATION ENERGY; BINDING ENERGY; CATALYSIS; ELECTRON TRANSITIONS; ENZYMES; FLUORINE; HYDROPHOBICITY; HYDROXYLATION; IRON COMPOUNDS; OXIDATION; PORPHYRINS; REGIOSELECTIVITY; SATURATED FATTY ACIDS; VAN DER WAALS FORCES;

SUBSTRATES;

CYTOCHROME P450; FATTY ACID; LAURIC ACID DERIVATIVE; PENTADECANOIC ACID; PERFLUORODODECANOIC ACID;

ARTICLE; C H ACTIVATION; CHEMISTRY; ENZYME CATALYSIS; FLUORINATED SUBSTITUENTS; HALOGENATION; HYDROGEN BOND; HYDROXYLATION; OXIDATION REDUCTION REACTION; VAN DER WAALS INTERACTIONS;

C H ACTIVATION; CYTOCHROME P450; ENZYME CATALYSIS; FLUORINATED SUBSTITUENTS; VAN DER WAALS INTERACTIONS;

CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS; HALOGENATION; HYDROGEN BONDING; HYDROXYLATION; LAURIC ACIDS; OXIDATION-REDUCTION;

EID: 84885382246     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201302402     Document Type: Article

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