Interactions of substrates at the surface of P450s can greatly enhance substrate potency

Biochemistry

Volumn 46, Issue 49, 2007, Pages 14010-14017

  Hegde, Amita ^a   Haines, Donovan C ^b   Bondlela, Muralidhar ^a   Chen, Baozhi ^a   Schaffer, Nathaniel ^a   Tomchick, Diana R ^a   Machius, Mischa ^a   Nguyen, Hien ^b   Chowdhary, Puneet K ^b   Stewart, Larissa ^b   Lopez, Claudia ^b   Peterson, Julian A ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME SOLVENT INTERFACE; HEME CONTAINING ENZYMES; NICOTINAMIDE;

ACYLATION; AMINO ACIDS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; FATTY ACIDS; MOLECULAR OXYGEN; SUBSTRATES;

PROTEINS;

CYTOCHROME P450; FATTY ACID; GLYCINE DERIVATIVE; METHIONINE DERIVATIVE; N PALMITOYL L METHIONINE; N PALMITOYLGLYCINE; PALMITIC ACID; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CRYSTAL STRUCTURE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN INTERACTION; SYNTHESIS;

BACTERIAL PROTEINS; BINDING SITES; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYTOCHROME P-450 ENZYME SYSTEM; FATTY ACIDS; LEUCINE; METHIONINE; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; PALMITIC ACIDS; SUBSTRATE SPECIFICITY;

MAMMALIA;

EID: 37049036628     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701667m     Document Type: Article

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