Preparation, therapeutic efficacy and intratumoral localization of targeted daunorubicin liposomes conjugating folate-PEG-CHEMS

Biomedicine and Pharmacotherapy

Volumn 65, Issue 1, 2011, Pages 2-8

  Xiong, Subin ^a,b   Yu, Bo ^b   Wu, Jun ^c   Li, Hong ^b   Lee, Robert J ^b  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antitumor; Daunorubicn; Folate receptor; Targeted liposomes

Indexed keywords

DAUNORUBICIN; FOLATE POLYETHYLENE GLYCOL CHOLESTEROL HEMISUCCINATE; FOLATE RECEPTOR; LIGAND; LIPOSOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONFOCAL MICROSCOPY; CONTINUOUS INFUSION; CONTROLLED STUDY; CYTOTOXICITY; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG RELEASE; DRUG RETENTION; DRUG SYNTHESIS; ENCAPSULATION; ENDOCYTOSIS; FEMALE; IC 50; IN VIVO STUDY; LOW DRUG DOSE; LYMPHATIC LEUKEMIA; MOUSE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SURVIVAL TIME; ZETA POTENTIAL;

ANIMALS; CHOLESTEROL; CHOLESTEROL ESTERS; DAUNORUBICIN; FEMALE; FOLIC ACID; LEUKEMIA L1210; LIPOSOMES; MICE; MICE, INBRED DBA; POLYETHYLENE GLYCOLS;

EID: 79951672863     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2010.10.003     Document Type: Article

References (31)

1. Elnakat H., Ratnam M. Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy. Adv Drug Deliv Rev 2004, 56:1067-1084.
2. Lu Y.H., Wu J., Wu J.M., Gonit M., Yang X.J., Lee A., et al. Role of formulation composition in folate receptor-targeted liposomal doxorubicin delivery to acute myelogenous leukemia cells. Mol Pharm 2007, 4:707-712.
3. Xia W., Hilgenbrink A.R., Matteson E.L., Lockwood M.B., Cheng J.X., Low P.S. A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages. Blood 2009, 113:438-446.
4. Gabizon A., Horowitz A.T., Goren D., Tzemach D., Shmeeda H., Zalipsky S. In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice. Clin Cancer Res 2003, 9:6551-6559.
5. Gabizon A., Shmeeda H., Horowitz A.T., Zalipsky S. Tumor cell targeting of liposome-entrapped drugs with phospholipid-anchored folic acid-peg conjugates. Adv Drug Deliv Rev 2004, 56:1177-1192.
6. Gabizon A., Tzemach D., Gorin J., Mak L., Amitay Y., Shmeeda H., et al. Improved therapeutic activity of folate-targeted liposomal doxorubicin in folate receptor-expressing tumor models. Cancer Chemother Pharmacol 2010, 66:43-52.
7. Li G., Li D., Zhang L., Zhai J., Wang E. One-step synthesis of folic acid protected gold nanoparticles and their receptor-mediated intracellular uptake. Chemistry 2009, 15:9868-9873.
8. Hayama A., Yamamoto T., Yokoyama M., Kawano K., Hattori Y., Maitani Y. Polymeric micelles modified by folate-peg-lipid for targeted drug delivery to cancer cells in vitro. J Nanosci Nanotechnol 2008, 8:3085-3090.
9. Gosselin M.A., Guo W.J., Lee R.J. Incorporation of reversibly cross-linked polyplexes into lpdii vectors for gene delivery. Bioconjugate Chem 2002, 13:1044-1053.
10. Low P.S., Henne W.A., Doorneweerd D.D. Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases. Acc Chem Res 2008, 41:120-129.
11. Allen T.M. Long-circulating (sterically stabilized) liposomes for targeted drug delivery. Trend Pharmacol Sci 1994, 15:215-220.
12. Klibanov A.L., Maruyama K., Torchilin V.P., Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett 1990, 268:235-237.
13. Allen T.M. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002, 2:750-763.
14. Saul J.M., Annapragada A.V., Bellamkonda R.V. A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. J Control Rel 2006, 114:277-287.
15. Zhao X.B., Muthusamy N., Byrd J.C., Lee R.J. Cholesterol as a bilayer anchor for pegylation and targeting ligand in folate-receptor-targeted liposomes. J Pharm Sci 2007, 96:2424-2435.
16. Wu J., Liu Q., Lee R.J. A folate receptor-targeted liposomal formulation for paclitaxel. Int J Pharm 2006, 316:148-153.
17. Lee R.J., Low P.S. Folate-mediated tumor cell targeting of liposome entrapped doxorubicin in vitro. Biochim Biophys Acta 1995, 1233:134-144.
18. Yamada A., Taniguchi Y., Kawano K., Honda T., Hattori Y., Maitani Y. Design of folate-linked liposomal doxorubicin to its antitumor effect in mice. Clin Cancer Res 2008, 14:8161-8168.
19. Goren D., Horowitz A.T., Tzemach D., Tarshish M., Zalipsky S., Gabizon A. Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump. Clin Cancer Res 2000, 6:1949-1957.
20. Shmeeda H., Mak L., Tzemach D., Astrahan P., Tarshish M., Gabizon A. Intracellular uptake and intracavitary targeting of folate-conjugated liposomes in a mouse lymphoma model with up-regulated folate receptors. Mol Cancer Ther 2006, 5:818-824.
21. Dauty E., Remy J.S., Zuber G., Behr J.P. Intracellular delivery of nanometric DNA particles via the folate receptor. Bioconjug Chem 2002, 13:831-839.
22. Saul J.M., Annapragada A., Natarajan J.V., Bellamkonda R.V. Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. J Control Rel 2003, 92:49-67.
23. Lee R.J., Huang L., Folate-targeted anionic liposome-entrapped polylysine-condensed DNA for tumor cell-specific gene transfer J Biol Chem 1996, 271:8481-8487.
24. Xiang G.Y., Wu J., Lu Y.H., Liu Z.L., Lee R.J. Synthesis and evaluation of a novel ligand for folate-mediated targeting liposomes. Int J Pharm 2008, 356:29-36.
25. Zhai G.X., Wu J., Xiang G.Y., Mao W.X., Yu B., Li H., et al. Preparation, characterization and pharmacokinetics of folate receptor-targeted liposomes for docetaxel delivery. J Nanosci Nanotechnol 2009, 9:2155-2161.
26. Wang X., Jansen G., Fan J., Kohler W.J., Ross J.F., Schornagel J., et al. Variant gpi structure in relation to membrane-associated functions of a murine folate receptor. Biochemistry 1996, 35:16305-16312.
27. Tomayko M.M., Reynolds C.P. Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 1989, 24:148-154.
28. Torchilin V.P. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005, 4:145-160.
29. Pan X.Q., Lee R.J. In vivo antitumor activity of folate receptor-targeted liposomal daunorubicin in a murine leukemia model. Anticancer Res 2005, 25:343-346.
30. Lasic D.D., Frederik P.M., Stuart M.C., Barenholz Y., McIntosh T.J. Gelation of liposome interior. A novel method for drug encapsulation. FEBS Lett 1992, 312:255-258.
31. Xiong S., Li H., Yu B., Wu J., Lee R.J. Triggering liposomal drug release with a lysosomotropic agent. J Pharm Sci 2010, 99:5011-5018. 10.1002/jps.22210.