Expression of the chemokines CXCL12 and CX3CL1 and their receptors in human nerve sheath tumors

Histology and Histopathology

Volumn 28, Issue 10, 2013, Pages 1337-1349

  Hattermann, Kirsten ^a   Li, Gu ^b,c   Hugo, Heinz Hermann ^b   Mentlein, Rolf ^a   Maximilian Mehdorn, H ^b   Held Feindt, Janka ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Chemokine; Chemokine receptor; Malignant peripheral nerve sheath tumor; Schwannoma

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR; CHEMOKINE RECEPTOR CXCR4; CX3CL1 PROTEIN, HUMAN; CX3CR1 PROTEIN, HUMAN; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; CXCR7 PROTEIN, HUMAN; FRACTALKINE; LIGAND; MESSENGER RNA; STROMAL CELL DERIVED FACTOR 1;

AGED; ARTICLE; CYTOLOGY; ENDOTHELIUM CELL; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; METABOLISM; MIDDLE AGED; NERVE SHEATH TUMOR; NEURILEMOMA;

AGED; CHEMOKINE CX3CL1; CHEMOKINE CXCL12; ENDOTHELIAL CELLS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; LIGANDS; MACROPHAGES; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; NERVE SHEATH NEOPLASMS; NEURILEMMOMA; RECEPTORS, CHEMOKINE; RECEPTORS, CXCR; RECEPTORS, CXCR4; RNA, MESSENGER;

EID: 84885368206     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Adler M.W., Geller E.B., Chen X. and Rogers T.J. (2006). Viewing chemokines as a third major system of communication in the brain. AAPS J. 7, E865-870.
2. Ammoun S., Schmid M.C., Zhou L., Ristic N., Ercolano E., Hilton D.A., Perks C.M. and Hanemann C.O. (2012). Insulin-like growth factor-binding protein-1 (IGFBP-1) regulates human schwannoma proliferation, adhesion and survival. Oncogene 31, 1710-1722.
3. Badache A. and DeVreis G.H. (1998). Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB. J. Cell. Physiol. 177, 334-342.
4. Balabanian K., Lagane B., Infantino S., Chow K.Y., Harriague J., Moepps B., Arenzana-Seisdedos F., Thelen M. and Bachelerie F. (2005). The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J. Biol. Chem. 280, 35760-35766.
5. Barbieri F., Bajetto A., Porcile C., Pattarozzi A., Massa A., Lunardi G., Zona G., Dorcaratto A., Ravetti J.L., Spaziante R., Schettini G. and Florio T. (2006). CXC receptor and chemokine expression in human meningioma: SDF1/CXCR4 signaling activates ERK1/2 and stimulates meningioma cell proliferation. Ann. N Y Acad. Sci. 1090, 332-343.
6. Barbieri F., Bajetto A., Stumm R., Pattarozzi A., Porcile C., Zona G., Dorcaratto A., Ravetti J.L., Minuto F., Spaziante R., Schettini G., Ferone D. and Florio T. (2008). Overexpression of stromal cell-derived factor 1 and its receptor CXCR4 induces autocrine/paracrine cell proliferation in human pituitary adenomas. Clin. Cancer Res. 14, 5022-5032.
7. Bazan J.F., Bacon K.B., Hardiman G., Wang W., Soo K., Rossi D., Greaves D.R., Zlotnik A. and Schall T.J. (1997). A new class of membrane-bound chemokine with a CX3C motif. Nature 385, 640-4.
8. Broxmeyer H.E. and Kim C.H. (1999). Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. Exp. Hematol. 27, 1113-1123.
9. Burns J.M., Summers B.C., Wang Y., Melikian A., Berahovich R., Miao Z., Penfold M.E., Sunshine M.J., Littman D.R., Kuo C.J., Wei K., McMaster B.E., Wright K., Howard M.C., Schall T.J. (2006). A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J. Exp. Med. 203, 2201-2213.
10. Celli P., Trillo G. and Ferrante L. (2005). Spinal extradural schwannoma. J. Neurosurg. Spine 2, 447-456.
11. Cipriani R., Villa P., Chece G., Lauro C., Paladini A., Micotti E., Perego C., De Simoni M.G., Fredholm B.B., Eusebi F. and Limatola C. (2011). CX3CL1 is neuroprotective in permanent focal cerebral ischemia in rodents. J. Neurosci. 31, 16327-16335.
12. Dambly-Chaudiere C., Cubedo N. and Ghysen A. (2007). Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. BMC Dev. Biol. 7, 23.
13. De Clerq E. (2003). The bicyclam AMD3100 story. Nat. Rev. Drug Discov. 2, 581-587.
14. D'Haese J.G., Demir I.E., Friess H. and Ceyhan G.O. (2010). Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential. Expert Opin. Ther. Targets 14, 207-219.
15. Dorsi M.J. and Belzberg A.J. (2004). Paraspinal nerve sheath tumors. Neurosurg. Clin. N. Am. 15, 217-222.
16. Evans D.G., Baser M.E., McGaughran J., Sharif S., Howard E. and Moran A. (2002). Malignant peripheral nerve sheath tumors in neurofibromatosis 1. J. Med. Genet. 39, 311-314.
17. Garton K.J., Gough P.J., Blobel C.P., Murphy G., Greaves D.R., Dempsey P.J. and Raines E.W. (2001). Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J. Biol. Chem. 276, 37993-38001.
18. Gaudin F., Nasreddine S., Donnadieu A.C., Emilie D., Combadière C., Prévot S., Machelon V. and Balabanian K. (2011). Identification of the chemokine CX3CL1 as a new regulator of malignant cell proliferation in epithelial ovarian cancer. PLoS One 6, e21546.
19. Greenberg M.S. (2006). Handbook of neurosurgery. Thieme Medical Publishers. New York, USA.
20. Gupta G., Mammis A. and Maniker A. (2008). Malignant peripheral nerve sheath tumors. Neurosurg. Clin. N. Am. 19, 533-543.
21. Halliday A.L., Sobel R.A. and Martuza R.L. (1991). Benign spinal nerve sheath tumors: Their occurrence sporiadically or in neurofibromatosis type 1 and 2. J. Neurosurg. 74, 248-253.
22. Hattermann K., Ludwig A., Gieselmann V., Held-Feindt J. and Mentlein R. (2008). The chemokine CXCL16 induces migration and invasion of glial precursor cells via its receptor CXCR6. Mol. Cell. Neurosci. 39, 133-141.
23. Hattermann K., Held-Feindt J., Lucius R., Sebens Müerköster S., Penfold M.E., Schall T.J. and Mentlein R. (2010). The chemokine receptor CXCR7 is highly expressed in human glioma cells and mediates anti-apoptotic effects. Cancer Res. 70, 3299-3308.
24. Hattermann K., Held-Feindt J. and Mentlein R. (2012). CXCL12 mediates apoptosis resistance in rat C6 glioma cells. Oncol. Rep. 27, 1348-1352.
25. Held-Feindt J., Hattermann K., Muerkoster S., Wedderkopp H., Knerlich- Lukoschus F., Ungefroren H., Mehdorn H.M. and Mentlein R. (2010). CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). Exp. Cell. Res. 316, 1553-1566.
26. Hughes P.M., Botham M.S., Frentzel S., Mir A. and Perry V.H. (2002). Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia 37, 314-27.
27. Hundhausen C., Misztela D., Berkhout T.A., Broadway N., Saftig P., Reiss K., Hartmann D., Fahrenholz F., Postina R., Matthews V., Kallen K.J., Rose-John S. and Ludwig A. (2003). The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion. Blood 102, 1186-1195.
28. Jamieson W.L., Shimizu S., D'Ambrosio J.A., Meucci O. and Fatatis A. (2008). CX3CR1 is expressed by prostate epithelial cells and androgens regulate the levels of CX3CL1/fractalkine in the bone marrow: potential role in prostate cancer bone tropism. Cancer Res. 68, 1715-1722.
29. Kourea H.P., Orlow I., Scheithauer B.W., Cordon-Cardo C. and Woodruff J.M. (1999). Deletions of INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas. Am. J. Pathol. 155, 1860-1866.
30. Küry P., Köller H., Hamacher M., Cornely C., Hasse B. and Müller H.W. (2003). Cyclic AMP and tumor necrosis factor-alpha regulate CXCR4 gene expression in Schwann cells. Mol. Cell. Neurosci. 24,1-9.
31. Li F., Wang Z., Liu Y. and Li J. (2010). Down-regulation of fractalkine inhibits the in vitro and in vivo angiogenesis of the hepatocellular carcinoma HepG2 cells. Oncol. Rep. 24, 669-675.
32. Louis D.N., Ohgaki H., Wiestler O.D. and Cavenee W.K. (eds) (2007) WHO Classification of tumours of the central nervous system. IARC Press. Lyon, France.
33. Ludwig A. and Weber C. (2007). Transmembrane chemokines: versatile 'special agents' in vascular inflammation. Thromb. Haemost. 97, 694-703.
34. Ludwig A. and Mentlein R. (2008). Glial cross-talk by transmembrane chemokines CX3CL1 and CXCL16. J. Neuroimmunol. 198, 92-97.
35. Ludwig A., Hundhausen C., Lambert M.H., Broadway N., Andrews R.C., Bickett D.M., Leesnitzer M.A. and Becherer J.D. (2005). Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules. Comb. Chem. High Throughput Screen 8, 161-71.
36. Marchesi F., Piemonti L., Fedele G., Destro A., Roncalli M., Albarello L., Doglioni C., Anselmo A., Doni A., Bianchi P., Laghi L., Malesci A., Cervo L., Malosio M., Reni M., Zerbi A., Di Carlo V., Mantovani A. and Allavena P. (2008). The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res. 68, 9060-9069.
37. Menon A.G., Anderson K.M., Riccardi V.M., Chung R.Y., Whaley J.M., Yandell D.W., Farmer G.E., Freiman R.N., Lee J.K., Li F.P., Barker D.F., Ledbetter D.H., Kleider A., Martuza R.L., Gusella J.F. and Seizinger B.R. (1990). Chromosome 17p deletions and p53 gene mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis. Proc. Natl. Acad. Sci. USA 87, 5435-5439.
38. Miao Z., Luker K.E., Summers B.C., Berahovich R., Bhojani M.S., Rehemtulla A., Kleer C.G., Essner J.J., Nasevicius A., Luker G.D., Howard M.C. and Schall T.J. (2007). CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc. Natl. Acad. Sci. USA 104, 15735-40.
39. Mori K., Chano T., Yamamoto K., Matsusue Y. and Okabe H. (2004). Expression of macrophage inflammatory protein-1alpha in Schwann cell tumors. Neuropathology 24, 131-135.
40. Müller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., McClanahan T., Murphy E., Yuan W., Wagner S.N., Barrera J.L., Mohar A., Verástegui E. and Zlotnik A. (2001). Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50-6.
41. Murphy P.M. (2002). International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Pharmacol. Rev. 54, 227-229.
42. O'Hayre M., Salanga C.L., Handel T.M. and Allen S.J. (2008). Chemokines and cancer: migration, intracellular signaling, and intercellular communication in the microenvironment. Biochem. J. 409, 635-649.
43. Ödemis V., Boosmann K., Heinen A., Küry P. and Engele J. (2010). CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells. J. Cell. Sci. 123,1081-8.
44. Pabon M.M., Bachstetter A.D., Hudson C.E., Gemma C. and Bickford P.C. (2011). CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease. J. Neuroinflammation 8, 9.
45. Patel J.R., McCandless E.E., Dorsey D. and Klein R.S. (2010). CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proc. Natl. Acad. Sci. USA 107,11062-7.
46. Patil K., Mahima V.G. and Ambika L. (2007). Malignant peripheral nerve sheath tumour: an elusive diagnosis. Indian J. Dent. Res. 18, 19-22.
47. Roche P.H., Bouvier C., Chinot O. and Figarella-Branger D. (2008). Genesis and biology of vestibular Schwannomas. Prog. Neurol. Surg. 21, 24-31.
48. Scheithauer B.W., Woodruff J.R. and Erlandson J. (1997). Tumors of the peripheral nervous system: Atlas of tumor pathologies. 3rd series. Fascicle 24. Washington, D.C., Armed Forces Institute of Pathology.
49. Schönemeier B., Kolodziej A., Schulz S., Jacobs S., Hoellt V. and Stumm R. (2008). Regional and cellular localization of the CXCL12/SDF-1 chemokine receptor CXCR7 in the developing and adult rat brain. J. Comp. Neurol. 10, 207-220.
50. Strieter R.M., Polverini P.J., Kunkel S.L., Arensberg D.A., Burdick M.D., Kasper J., Dzuiba J., Damme J.V., Walz A., Marriot D., Chan S.Y., Roczniak S. and Shanafelt A.B. (1995). The functional role of the ERL-motif in CXC chemokine-mediated angiogenesis. J. Biol. Chem. 270, 27348-27357.
51. Stumm R.K., Rummel J., Junker V., Culmsee C., Pfeiffer M., Krieglstein J., Höllt V. and Schulz S. (2002). A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia. J. Neurosci. 22, 5865-5878.
52. Tang L., Hu H.D., Hu P., Lan Y.H., Peng M.L., Chen M. and Ren H. (2007). Gene therapy with CX3CL1/Fractalkine induces antitumor immunity to regress effectively mouse hepatocellular carcinoma. Gene Ther. 14, 1226-1234.
53. Tos M. and Thomsen J. (1984). Epidemiology of acoustic neuromas. J. Laryngol. Otol. 98, 685-692.
54. Vandercappellen J., Van Damme J. and Struyf S. (2008). The role of CXC chemokines and their receptors in cancer. Cancer Lett. 28, 226-44.
55. Wang J., Shiozawa Y., Wang J., Wang Y., Jung Y., Pienta K.J., Mehra R., Loberg R. and Taichman R.S. (2008). The role of CXCR7 / RDC1 as a chemokine receptor for CXCL12 / SDF-1 in prostate cancer. J. Biol. Chem. 283, 4283-4294.
56. Weerda H.G., Gamberger T.I., Siegner A., Gjuric M. and Tamm E.R. (1998). Effects of transforming growth factor-beta1 and basic fibroblast growth factor on proliferation of cell cultures derived from human vestibular nerve schwannoma. Acta Otolaryngol. 118, 337-343.
57. Weiss S.W., Langloss J.M. and Enzinger F.M. (1983). Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Lab. Invest. 49, 299-308.
58. Woodruff J.M., Selig A.M., Crowley K. and Allen P.W. (1994). Schwannoma (neurilemoma) with malignant transformation. A rare, distinctive peripheral nerve tumor. Am. J. Surg. Pathol. 18, 882-895.
59. Zhou W., Jiang Z., Song X., Liu Y., Wen P., Guo Y., Xu F., Kong L., Zhang P., Han A. and Yu J. (2008). Promoter hypermethylation-mediated down-regulation of CXCL12 in human astrocytoma. J. Neurosci. Res. 86, 3002-3010.
60. Zlotnik A., Burkhardt A.M. and Homey B. (2011). Homeostatic chemokine receptors and organ-specific metastasis. Nat. Rev. Immunol. 11, 597-606.