Promoter hypermethylation-mediated down-regulation of CXCL12 in human astrocytoma

Journal of Neuroscience Research

Volumn 86, Issue 13, 2008, Pages 3002-3010

  Zhou, Wei ^a,b   Jiang, Zheng ^c   Song, Xianrang ^b   Liu, Yonglei ^b   Wen, Peie ^d   Guo, Yuan ^c   Xu, Fenghua ^b   Kong, Li ^b   Zhang, Pinliang ^b   Han, Anqin ^b   Yu, Jinming ^b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

^c SHANDONG UNIVERSITY   (China)

^d SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Epigenetic; Gene regulation; Methyl CpG binding protein; Neuropathology

Indexed keywords

BIOLOGICAL MARKER; CHEMOKINE RECEPTOR CXCR4; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; MESSENGER RNA; STROMAL CELL DERIVED FACTOR 1;

ADOLESCENT; ADULT; ARTICLE; ASTROCYTOMA; CANCER GRADING; CARCINOGENESIS; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; ENZYME INACTIVATION; EPIGENETICS; FEMALE; GENE SILENCING; GENETIC TRANSCRIPTION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; SIGNAL TRANSDUCTION; WORLD HEALTH ORGANIZATION;

ADULT; ASTROCYTOMA; BRAIN NEOPLASMS; CHEMOKINE CXCL12; DNA METHYLATION; DOWN-REGULATION; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 57049180721     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21746     Document Type: Article

References (36)

1. Bajetto A, Barbieri F, Dorcaratto A, Barbero S, Daga A, Porcile C, Ravetti JL, Zona G, Spaziante R, Corte G, Schettini G, Florio T. 2006. Expression of CXC chemokine receptors 1-5 and their ligands in human glioma tissues: role of CXCR4 and SDF1 in glioma cell proliferation and migration. Neurochem Int 49:423-432.
2. Balkwill F. 2004. Cancer and the chemokine network. Nat Rev Cancer 4:540-550.
3. Bestor TH. 2000. The DNA methyltransferases of mammals. Hum Mol Genet 9:2395-2402.
4. Bleul CC, Fuhlbrigge RC, Casasnovas JM, Aiuti A, Springer TA. 1996. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med 184:1101-1109.
5. Chu CY, Cha ST, Chang CC, Hsiao CH, Tan CT, Lu YC, Jee SH, Kuo ML. 2007. Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells. Oncogene 26:2491-2501.
6. Costello JF. 2003. DNA methylation in brain development and gliomagenesis. Front Biosci 8:s175-184.
7. Ehtesham M, Winston JA, Kabos P, Thompson RC. 2006. CXCR4 expression mediates glioma cell invasiveness. Oncogene 25:2801-2806.
8. Esteller M, Corn PG, Baylin SB, Herman JG. 2001. A gene hypermethylation profile of human cancer. Cancer Res 61:3225-3229.
9. Girault I, Tozlu S, Lidereau R, Bièche I. 2003. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 9:4415-4422.
10. Goelz SE, Hamilton SR, Vogelstein B. 1985. Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun 130:118-126.
11. Grunau C, Clark SJ, Rosenthal A. 2001. Bisulfate genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res 29:E65.
12. Herman JG, Graff JR, Myöhänen S, Nelkin BD, Baylin SB. 1996. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 93:9821-9826.
13. Hong X, Jiang F, Kalkanis SN, Zhang ZG, Zhang XP, DeCarvalho AC, Katakowski M, Bobbitt K, Mikkelsen T, Chopp M. 2006. SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. Cancer Lett 236:39-45.
14. Jiang Z, Li X, Hu J, Zhou W, Jiang Y, Li G, Lu D. 2006. Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res 56:450-458.
15. Kim J, Mori T, Chen SL, Amersi FF, Martinez SR, Kuo C, Turner RR, Ye X, Bilchik AJ, Morton DL, Hoon DS. 2006. Chemokine receptor CXCR4 expression in patients with melanoma and colorectal cancer liver metastases and the association with disease outcome. Ann Surg 244:113-120.
16. Kleihues P, Cavenee W. 2000. Astrocytic tumours. In: Kleihues P, Cavenee W, editors. Pathology and genetics tumours of the nervous system. Lyon: IARC Press. p 9-54.
17. Kwon YM, Park JH, Kim H, Shim YM, Kim J, Han J, Park J, Kim DH. 2007. Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer. J Cancer Res Clin Oncol 133:219-226.
18. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408.
19. Maroni P, Bendinelli P, Matteucci E, Desiderio MA. 2007. HGF induces CXCR4 and CXCL12-mediated tumor invasion through Ets1 and NF-kappaB. Carcinogenesis 28:267-279.
20. Müller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verástegui E, Zlotnik A. 2001. Involvement of chemokine receptors in breast cancer metastases. Nature 410:50-56.
21. Ottaiano A, di Palma A, Napolitano M, Pisano C, Pignata S, Tatangelo F, Botti G, Acquaviva AM, Castello G, Ascierto PA, Iaffaioli RV, Scala S. 2005. Inhibitory effects of anti-CXCR4 antibodies on human colon cancer cells. Cancer Immunol Immunother 54:781-791.
22. Rempel SA, Dudas S, Ge S, Gutiérrez JA. 2000. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin Cancer Res 6:102-111.
23. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. 2002. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416:552-556.
24. Robertson KD. 2001. DNA methylation, methyltransferases, and cancer. Oncogene 20:3139-3155.
25. Salmaggi A, Gelati M, Pollo B, Frigerio S, Eoli M, Silvani A, Broggi G, Ciusani E, Croci D, Boiardi A, De Rossi M. 2004. CXCL12 in malignant glial tumors: a possible role in angiogenesis and cross-talk between endothelial and tumoral cells. J Neurooncol 67:305-317.
26. Salmaggi A, Gelati M, Pollo B, Marras C, Silvani A, Balestrini MR, Eoli M, Fariselli L, Broggi G, Boiardi A. 2005. CXCL12 expression is predictive of a shorter time to tumor progression in low-grade glioma: a single-institution study in 50 patients. J Neurooncol 74:287-293.
27. Scala S, Giuliano P, Ascierto PA, Ieranó C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caracó C, Nicoletti G, Satriano RA, Castello G. 2006. Human melanoma metastases express functional CXCR4. Clin Cancer Res 12:2427-2433.
28. Schimanski CC, Bahre R, Gockel I, Müller A, Frerichs K, Hörner V, Teufel A, Simiantonaki N, Biesterfeld S, Wehler T, Schuler M, Achenbach T, Junginger T, Galle PR, Moehler M. 2006. Dissemination of hepatocellular carcinoma is mediated via chemokine receptor CXCR4. Br J Cancer 95:210-217.
29. Sehgal A, Keener C, Boynton AL, Warrick J, Murphy GP. 1998. CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells. J Surg Oncol 69:99-104.
30. Siedlecki P, Zielenkiewicz P. 2006. Mammalian DNA methyltransferases. Acta Biochim Pol 53:245-256.
31. Sowinska A, Jagodzinski PP. 2007. RNA interference-mediated knockdown of DNMT1 and DNMT3B induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines. Cancer Lett 255:153-159.
32. Tabatabai G, Frank B, Möhle R, Weller M, Wick W. 2006. Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12. Brain 129:2426-2435.
33. Waha A, Güntner S, Huang TH, Yan PS, Arslan B, Pietsch T, Wiestler OD, Waha A. 2005. Epigenetic silencing of the protocadherin family member PCDH-gamma-A11 in astrocytomas. Neoplasia 7:193-199.
34. Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Lober R, Taichman RS. 2007. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem [E-pub ahead of print].
35. Wendt MK, Johanesen PA, Kang-Decker N, Binion DG, Shah V, Dwinell MB. 2006. Silencing of epithelial CXCL12 expression by DNA hypermethylation promotes colonic carcinoma metastasis. Oncogene 25:4986-4997.
36. Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali MA, Melamed J, Semenza GL. 2005. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res 65:6178-6188.