Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1215-1228

  Benavides, Gloria A ^a,b   Liang, Qiuli ^a,b   Dodson, Matthew ^a,b   Darley Usmar, Victor ^a,b   Zhang, Jianhua ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c BIRMINGHAM VA MEDICAL CENTER   (United States)

Author keywords

2 DG; 3 MA; DetaNONOate; Free radicals; Glucose; LC3; Mitochondria

Indexed keywords

3 METHYLADENINE; CYTOCHROME C OXIDASE; DEOXYGLUCOSE; NITRIC OXIDE; PROTON IONOPHORE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BIOENERGY; BRAIN CELL; CELL DAMAGE; CELL HYPOXIA; CELL METABOLISM; CELL PROTECTION; CELL RESPIRATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; EMBRYO; GLUCOSE METABOLISM; GLYCOLYSIS; IN VITRO STUDY; MITOCHONDRIAL RESPIRATION; NERVE CELL CULTURE; NERVE CELL NECROSIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; OXYGEN TENSION; PRIORITY JOURNAL; RAT; REOXYGENATION; RESPIRATORY CHAIN; STEADY STATE; WESTERN BLOTTING;

RATTUS;

DETANO, (Z)-1-[N-(2-AMINOETHYL)-N-(2-AMMONIOETHYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE; 2-DEOXYGLUCOSE; 2-DG; 3-MA; 3-METHYLADENINE; CARBONYL CYANIDE 4-(TRIFLUOROMETHOXY)PHENYLHYDRAZONE; CHLOROQUINE; CQ; DETANONOATE; ECAR; EXTRACELLULAR ACIDIFICATION RATE; FCCP; FREE RADICALS; GLUCOSE; LC3; MICROTUBULE-ASSOCIATED PROTEIN LIGHT-CHAIN 3; MITOCHONDRIA; NITRIC OXIDE SYNTHASE; NOS; OCR; OXYGEN CONSUMPTION RATE;

ADENINE; ANIMALS; AUTOPHAGY; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; DEOXYGLUCOSE; ENDOTHELIAL CELLS; ENERGY METABOLISM; GLYCOLYSIS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NEURONS; NITRIC OXIDE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES;

EID: 84885332889     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.09.006     Document Type: Article

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