MicroRNA-mediated epigenetic silencing of sirtuin1 contributes to impaired angiogenic responses

Circulation Research

Volumn 113, Issue 8, 2013, Pages 997-1003

  Volkmann, Ingo ^a   Kumarswamy, Regalla ^a   Pfaff, Nils ^a   Fiedler, Jan ^a   Dangwal, Seema ^a   Holzmann, Angelika ^a   Batkai, Sandor ^a   Geffers, Robert ^b   Lother, Achim ^c,d   Hein, Lutz ^c   Thum, Thomas ^a,e  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY HEART CENTER FREIBURG BAD KROZINGEN   (Germany)

^e NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Angiogenic responses; Endothelial cells; Epigenomics; Methyl CpG binding protein 2; microRNAs; Sirt1 protein, mouse; Transforming growth factor beta

Indexed keywords

METHYL CPG BINDING PROTEIN 2; MICRORNA; MICRORNA 30A 3P; SIRTUIN 1; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EPIGENETICS; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANGIOGENIC RESPONSES; ENDOTHELIAL CELLS; EPIGENOMICS; METHYL-CPG-BINDING PROTEIN 2; MICRORNAS; SIRT1 PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA;

ANIMALS; CELL MOVEMENT; ENDOTHELIAL CELLS; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE SILENCING; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; METHYL-CPG-BINDING PROTEIN 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SIRTUIN 1; TISSUE CULTURE TECHNIQUES; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84885309959     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.113.301702     Document Type: Article

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