메뉴 건너뛰기




Volumn 98, Issue 10, 2013, Pages

Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE;

EID: 84885236294     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-1642     Document Type: Article
Times cited : (36)

References (40)
  • 1
    • 78649842241 scopus 로고    scopus 로고
    • Genomics, type 2 diabetes, and obesity
    • McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med. 2010; 363: 2339-2350.
    • (2010) N Engl J Med. , vol.363 , pp. 2339-2350
    • McCarthy, M.I.1
  • 2
    • 80053927394 scopus 로고    scopus 로고
    • Genetics of type 2 diabetes: The GWAS era and future perspectives
    • Imamura M, Maeda S. Genetics of type 2 diabetes: the GWAS era and future perspectives. Endocr J. 2011; 58: 723-739.
    • (2011) Endocr J , vol.58 , pp. 723-739
    • Imamura, M.1    Maeda, S.2
  • 3
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J., et al A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007; 445: 881-885.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 4
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signal in UK samples reveals risk loci for type 2 diabetes
    • Wellcome Trust Case Control Consortium (WTCCC)
    • Zeggini E, Weedon MN, Lindgren C.M., et al.; Wellcome Trust Case Control Consortium (WTCCC). Replication of genome-wide association signal in UK samples reveals risk loci for type 2 diabetes. Science. 2007; 316: 1336-1341.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 5
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle L.L., et al A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007; 316: 1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 6
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research
    • Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research; Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007; 316: 1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 7
    • 34249828965 scopus 로고    scopus 로고
    • A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
    • Steinthorsdottir V, Thorleifsson G, Reynisdottir I., et al A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007; 39: 770-775.
    • (2007) Nat Genet. , vol.39 , pp. 770-775
    • Steinthorsdottir, V.1    Thorleifsson, G.2    Reynisdottir, I.3
  • 8
    • 42349106044 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    • Zeggini E, Scott LJ, Saxena R, et al Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008; 40: 638-645.
    • (2008) Nat Genet , vol.40 , pp. 638-645
    • Zeggini, E.1    Scott, L.J.2    Saxena, R.3
  • 9
    • 70349557826 scopus 로고    scopus 로고
    • Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
    • Rung J, Cauchi S, Albrechtsen A., et al Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet. 2009; 41: 1110-1115.
    • (2009) Nat Genet. , vol.41 , pp. 1110-1115
    • Rung, J.1    Cauchi, S.2    Albrechtsen, A.3
  • 10
    • 58149175669 scopus 로고    scopus 로고
    • Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
    • Lyssenko V, Nagorny CL, Erdos M.R., et al Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009; 41: 82-88.
    • (2009) Nat Genet. , vol.41 , pp. 82-88
    • Lyssenko, V.1    Nagorny, C.L.2    Erdos, M.R.3
  • 11
    • 58149175143 scopus 로고    scopus 로고
    • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
    • Bouatia-Naji N., Bonnefond A, Cavalcanti-Proença C, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009; 41: 89-94.
    • (2009) Nat Genet. , vol.41 , pp. 89-94
    • Bouatia-Naji, N.1    Bonnefond, A.2    Cavalcanti-Proença, C.3
  • 12
    • 75749086085 scopus 로고    scopus 로고
    • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    • DIAGRAM Consortium; GIANTConsortium; Global BPgen Consortium
    • Dupuis J, Langenberg C, Prokopenko I., et al.; DIAGRAM Consortium; GIANTConsortium; Global BPgen Consortium. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010; 42: 105-116.
    • (2010) Nat Genet , vol.42 , pp. 105-116
    • Dupuis, J.1    Langenberg, C.2    Prokopenko, I.3
  • 13
    • 77954143522 scopus 로고    scopus 로고
    • Twelve type2diabetes susceptibility loci identified through large-scale association analysis
    • MAGIC investigators; GIANTConsortium
    • Voight BF, Scott LJ, Steinthorsdottir V, et al.; MAGIC investigators; GIANTConsortium. Twelve type2diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010; 42: 579-589.
    • (2010) Nat Genet , vol.42 , pp. 579-589
    • Voight, B.F.1    Scott, L.J.2    Steinthorsdottir, V.3
  • 14
    • 84655162045 scopus 로고    scopus 로고
    • Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east asians
    • DIAGRAM Consortium; MuTHER Consortium
    • Cho YS, Chen CH, Hu C, et al.; DIAGRAM Consortium; MuTHER Consortium. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011; 44: 67-72.
    • (2011) Nat Genet , vol.44 , pp. 67-72
    • Cho, Y.S.1    Chen, C.H.2    Hu, C.3
  • 15
    • 80053385333 scopus 로고    scopus 로고
    • Genome-wide association study in individuals of south asian ancestry identifies six new type 2 diabetes susceptibility loci
    • DIAGRAM; MuTHER
    • Kooner JS, Saleheen D, Sim X., et al.; DIAGRAM; MuTHER. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011; 43: 984-989.
    • (2011) Nat Genet , vol.43 , pp. 984-989
    • Kooner, J.S.1    Saleheen, D.2    Sim, X.3
  • 16
    • 50449085212 scopus 로고    scopus 로고
    • SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in east asian and european populations
    • Unoki H, Takahashi A, Kawaguchi T., et al SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet. 2008; 40: 1098-1102.
    • (2008) Nat Genet. , vol.40 , pp. 1098-1102
    • Unoki, H.1    Takahashi, A.2    Kawaguchi, T.3
  • 17
    • 50449085998 scopus 로고    scopus 로고
    • Variants in KCNQ1 are associated with susceptibilityto type2 diabetes mellitus
    • Yasuda K, Miyake K, Horikawa Y., et al Variants in KCNQ1 are associated with susceptibilityto type2 diabetes mellitus. Nat Genet. 2008; 40: 1092-1097.
    • (2008) Nat Genet. , vol.40 , pp. 1092-1097
    • Yasuda, K.1    Miyake, K.2    Horikawa, Y.3
  • 18
    • 77957553197 scopus 로고    scopus 로고
    • A genome-wide association studyinthe Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
    • Yamauchi T, Hara K, Maeda S., et al A genome-wide association studyinthe Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet. 2010; 42: 864-868.
    • (2010) Nat Genet , vol.42 , pp. 864-868
    • Yamauchi, T.1    Hara, K.2    Maeda, S.3
  • 19
    • 84863503465 scopus 로고    scopus 로고
    • A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations
    • Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium
    • Imamura M, Maeda S, Yamauchi T., et al.; Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet. 2012; 10: 1093-1113.
    • (2012) Hum Mol Genet , vol.10 , pp. 1093-1113
    • Imamura, M.1    Maeda, S.2    Yamauchi, T.3
  • 20
    • 78049438674 scopus 로고    scopus 로고
    • Identification of new genetic risk variants for type 2 diabetes
    • Shu XO, Long J, Cai Q., et al Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 2010; 6: e1001127.
    • (2010) PLoS Genet , vol.6
    • Shu, X.O.1    Long, J.2    Cai, Q.3
  • 21
    • 84868337361 scopus 로고    scopus 로고
    • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
    • Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEnT2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
    • Morris AP, Voight BF, Teslovich T.M., et al.; Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012; 44: 981-990.
    • (2012) Nat Genet , vol.44 , pp. 981-990
    • Morris, A.P.1    Voight, B.F.2    Teslovich, T.M.3
  • 22
    • 80755140152 scopus 로고    scopus 로고
    • A methodological perspective on genetic risk prediction studies in type 2 diabetes: Recommendations for future research
    • Willems SM, Mihaescu R, Sijbrands E.J., van Duijn CM, Janssens AC A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research. Curr Diab Rep. 2011; 11: 511-518.
    • (2011) Curr Diab Rep , vol.11 , pp. 511-518
    • Willems, S.M.1    Mihaescu, R.2    Sijbrands, E.J.3    Van Duijn, C.M.4    Janssens, A.C.5
  • 23
    • 55649105963 scopus 로고    scopus 로고
    • Clinical risk factors, DNA variants, and the development of type 2 diabetes
    • Lyssenko V, Jonsson A, Almgren P., et al Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008; 359: 2220-2232.
    • (2008) N Engl J Med. , vol.359 , pp. 2220-2232
    • Lyssenko, V.1    Jonsson, A.2    Almgren, P.3
  • 24
    • 56749101779 scopus 로고    scopus 로고
    • Genotype score in addition to common risk factors for prediction of type 2 diabetes
    • Meigs JB, Shrader P, Sullivan L.M., et al Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008; 359: 2208-2219.
    • (2008) N Engl J Med. , vol.359 , pp. 2208-2219
    • Meigs, J.B.1    Shrader, P.2    Sullivan, L.M.3
  • 25
    • 76249109928 scopus 로고    scopus 로고
    • Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
    • Talmud PJ, Hingorani AD, Cooper J.A., et al Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ. 2010; 340: b4838.
    • (2010) BMJ , vol.340
    • Talmud, P.J.1    Hingorani, A.D.2    Cooper, J.A.3
  • 26
    • 79951715822 scopus 로고    scopus 로고
    • DIAGRAM + investigators genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
    • MAGIC Investigators
    • de Miguel-Yanes JM, Shrader P, Pencina MJ, et al.; MAGIC Investigators; DIAGRAM + Investigators Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care. 2011; 34: 121-125.
    • (2011) Diabetes Care , vol.34 , pp. 121-125
    • De Miguel-Yanes, J.M.1    Shrader, P.2    Pencina, M.J.3
  • 27
    • 66249089500 scopus 로고    scopus 로고
    • Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association
    • Miyake K, Yang W, Hara K., et al Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet. 2009; 54: 236-241.
    • (2009) J Hum Genet , vol.54 , pp. 236-241
    • Miyake, K.1    Yang, W.2    Hara, K.3
  • 28
    • 80054979509 scopus 로고    scopus 로고
    • Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: The shimanami health promoting program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score
    • Tabara Y, Osawa H, Kawamoto R., et al Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score. Metabolism. 2011; 60: 1634-1640.
    • (2011) Metabolism , vol.60 , pp. 1634-1640
    • Tabara, Y.1    Osawa, H.2    Kawamoto, R.3
  • 29
    • 84864383698 scopus 로고    scopus 로고
    • Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals
    • Iwata M, Maeda S, Kamura Y., et al Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals. Diabetes Care. 2012; 35: 1763-1770.
    • (2012) Diabetes Care , vol.35 , pp. 1763-1770
    • Iwata, M.1    Maeda, S.2    Kamura, Y.3
  • 30
    • 84863670156 scopus 로고    scopus 로고
    • Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared with obese cases
    • MAGIC; DIAGRAM Consortium; GIANT Consortium
    • Perry JR, Voight BF, Yengo L, et al.; MAGIC; DIAGRAM Consortium; GIANT Consortium. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared with obese cases. PLoS Genet. 2012; 8: e1002741.
    • (2012) PLoS Genet , vol.8
    • Perry, J.R.1    Voight, B.F.2    Yengo, L.3
  • 31
    • 84857249788 scopus 로고    scopus 로고
    • The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: A population based case-control study
    • Yamakawa-Kobayashi K., Natsume M, Aoki S., et al The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study. BMC Med Genet. 2012; 24: 13-11.
    • (2012) BMC Med Genet , vol.24 , pp. 13-11
    • Yamakawa-Kobayashi, K.1    Natsume, M.2    Aoki, S.3
  • 32
    • 80055035412 scopus 로고    scopus 로고
    • Association of new loci identified in european genome-wide association studies with susceptibility to type 2 diabetes in the Japanese
    • Ohshige T, Iwata M, Omori S., et al Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One. 2011; 6: e26911.
    • (2011) PLoS One , vol.6
    • Ohshige, T.1    Iwata, M.2    Omori, S.3
  • 33
    • 82455198579 scopus 로고    scopus 로고
    • Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population
    • Imamura M, Iwata M, Maegawa H., et al Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population. Diabetologia. 2011; 54: 3071-3077.
    • (2011) Diabetologia , vol.54 , pp. 3071-3077
    • Imamura, M.1    Iwata, M.2    Maegawa, H.3
  • 34
    • 84866946023 scopus 로고    scopus 로고
    • A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population
    • Fukuda H, Imamura M, Tanaka Y., et al A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population. PLoS One. 2012; 7: e46263.
    • (2012) PLoS One , vol.7
    • Fukuda, H.1    Imamura, M.2    Tanaka, Y.3
  • 35
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998; 15: 539-553.
    • (1998) Diabet Med. , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 36
    • 23844472598 scopus 로고    scopus 로고
    • Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
    • Maeda S, Tsukada S, Kanazawa A., Set al Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet. 2005; 50: 283-292.
    • (2005) J Hum Genet. , vol.50 , pp. 283-292
    • Maeda, S.1    Tsukada, S.2    Kanazawa, A.S.3
  • 37
    • 84865693929 scopus 로고    scopus 로고
    • Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
    • DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium
    • Scott RA, Lagou V, Welch R.P., et al.; DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012; 44: 991-1005.
    • (2012) Nat Genet , vol.44 , pp. 991-1005
    • Scott, R.A.1    Lagou, V.2    Welch, R.P.3
  • 38
    • 0032231375 scopus 로고    scopus 로고
    • Detecting marker-disease association by testing for hardy-weinberg disequilibrium at a marker locus
    • Nielsen DM, Ehm MG, Weir BS Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am J Hum Genet. 1998; 63: 1531-1540.
    • (1998) Am J Hum Genet , vol.63 , pp. 1531-1540
    • Nielsen, D.M.1    Ehm, M.G.2    Weir, B.S.3
  • 39
    • 0036856963 scopus 로고    scopus 로고
    • New criteria for 'obesity disease' in Japan
    • Examination Committee of Criteria for 'Obesity Disease' in Japan, Japan Society for the Study of Obesity
    • Examination Committee of Criteria for 'Obesity Disease' in Japan, Japan Society for the Study of Obesity. New criteria for 'obesity disease' in Japan. Circ J. 2002; 66: 987-992.
    • (2002) Circ J , vol.66 , pp. 987-992
  • 40
    • 34948845069 scopus 로고    scopus 로고
    • Association study of the genetic polymorphisms of the transcription factor 7-like2(TCF7L2) gene and type 2 diabetes in the Chinese population
    • Chang YC, Chang TJ, Jiang Y.D., et al Association study of the genetic polymorphisms of the transcription factor 7-like2(TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes. 2007; 56: 2631-2637.
    • (2007) Diabetes , vol.56 , pp. 2631-2637
    • Chang, Y.C.1    Chang, T.J.2    Jiang, Y.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.