-
1
-
-
78649842241
-
Genomics, type 2 diabetes, and obesity
-
McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med. 2010; 363: 2339-2350.
-
(2010)
N Engl J Med.
, vol.363
, pp. 2339-2350
-
-
McCarthy, M.I.1
-
2
-
-
80053927394
-
Genetics of type 2 diabetes: The GWAS era and future perspectives
-
Imamura M, Maeda S. Genetics of type 2 diabetes: the GWAS era and future perspectives. Endocr J. 2011; 58: 723-739.
-
(2011)
Endocr J
, vol.58
, pp. 723-739
-
-
Imamura, M.1
Maeda, S.2
-
3
-
-
33847176604
-
A genome-wide association study identifies novel risk loci for type 2 diabetes
-
Sladek R, Rocheleau G, Rung J., et al A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature. 2007; 445: 881-885.
-
(2007)
Nature
, vol.445
, pp. 881-885
-
-
Sladek, R.1
Rocheleau, G.2
Rung, J.3
-
4
-
-
34249895023
-
Replication of genome-wide association signal in UK samples reveals risk loci for type 2 diabetes
-
Wellcome Trust Case Control Consortium (WTCCC)
-
Zeggini E, Weedon MN, Lindgren C.M., et al.; Wellcome Trust Case Control Consortium (WTCCC). Replication of genome-wide association signal in UK samples reveals risk loci for type 2 diabetes. Science. 2007; 316: 1336-1341.
-
(2007)
Science
, vol.316
, pp. 1336-1341
-
-
Zeggini, E.1
Weedon, M.N.2
Lindgren, C.M.3
-
5
-
-
34249885875
-
A genome-wide association study of type 2 diabetes in finns detects multiple susceptibility variants
-
Scott LJ, Mohlke KL, Bonnycastle L.L., et al A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007; 316: 1341-1345.
-
(2007)
Science
, vol.316
, pp. 1341-1345
-
-
Scott, L.J.1
Mohlke, K.L.2
Bonnycastle, L.L.3
-
6
-
-
34249888775
-
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
-
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research
-
Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research; Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007; 316: 1331-1336.
-
(2007)
Science
, vol.316
, pp. 1331-1336
-
-
Saxena, R.1
Voight, B.F.2
Lyssenko, V.3
-
7
-
-
34249828965
-
A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
-
Steinthorsdottir V, Thorleifsson G, Reynisdottir I., et al A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet. 2007; 39: 770-775.
-
(2007)
Nat Genet.
, vol.39
, pp. 770-775
-
-
Steinthorsdottir, V.1
Thorleifsson, G.2
Reynisdottir, I.3
-
8
-
-
42349106044
-
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
-
Zeggini E, Scott LJ, Saxena R, et al Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008; 40: 638-645.
-
(2008)
Nat Genet
, vol.40
, pp. 638-645
-
-
Zeggini, E.1
Scott, L.J.2
Saxena, R.3
-
9
-
-
70349557826
-
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
-
Rung J, Cauchi S, Albrechtsen A., et al Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat Genet. 2009; 41: 1110-1115.
-
(2009)
Nat Genet.
, vol.41
, pp. 1110-1115
-
-
Rung, J.1
Cauchi, S.2
Albrechtsen, A.3
-
10
-
-
58149175669
-
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
-
Lyssenko V, Nagorny CL, Erdos M.R., et al Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet. 2009; 41: 82-88.
-
(2009)
Nat Genet.
, vol.41
, pp. 82-88
-
-
Lyssenko, V.1
Nagorny, C.L.2
Erdos, M.R.3
-
11
-
-
58149175143
-
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
-
Bouatia-Naji N., Bonnefond A, Cavalcanti-Proença C, et al. A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. Nat Genet. 2009; 41: 89-94.
-
(2009)
Nat Genet.
, vol.41
, pp. 89-94
-
-
Bouatia-Naji, N.1
Bonnefond, A.2
Cavalcanti-Proença, C.3
-
12
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
DIAGRAM Consortium; GIANTConsortium; Global BPgen Consortium
-
Dupuis J, Langenberg C, Prokopenko I., et al.; DIAGRAM Consortium; GIANTConsortium; Global BPgen Consortium. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010; 42: 105-116.
-
(2010)
Nat Genet
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
Langenberg, C.2
Prokopenko, I.3
-
13
-
-
77954143522
-
Twelve type2diabetes susceptibility loci identified through large-scale association analysis
-
MAGIC investigators; GIANTConsortium
-
Voight BF, Scott LJ, Steinthorsdottir V, et al.; MAGIC investigators; GIANTConsortium. Twelve type2diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010; 42: 579-589.
-
(2010)
Nat Genet
, vol.42
, pp. 579-589
-
-
Voight, B.F.1
Scott, L.J.2
Steinthorsdottir, V.3
-
14
-
-
84655162045
-
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east asians
-
DIAGRAM Consortium; MuTHER Consortium
-
Cho YS, Chen CH, Hu C, et al.; DIAGRAM Consortium; MuTHER Consortium. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet. 2011; 44: 67-72.
-
(2011)
Nat Genet
, vol.44
, pp. 67-72
-
-
Cho, Y.S.1
Chen, C.H.2
Hu, C.3
-
15
-
-
80053385333
-
Genome-wide association study in individuals of south asian ancestry identifies six new type 2 diabetes susceptibility loci
-
DIAGRAM; MuTHER
-
Kooner JS, Saleheen D, Sim X., et al.; DIAGRAM; MuTHER. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011; 43: 984-989.
-
(2011)
Nat Genet
, vol.43
, pp. 984-989
-
-
Kooner, J.S.1
Saleheen, D.2
Sim, X.3
-
16
-
-
50449085212
-
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in east asian and european populations
-
Unoki H, Takahashi A, Kawaguchi T., et al SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet. 2008; 40: 1098-1102.
-
(2008)
Nat Genet.
, vol.40
, pp. 1098-1102
-
-
Unoki, H.1
Takahashi, A.2
Kawaguchi, T.3
-
17
-
-
50449085998
-
Variants in KCNQ1 are associated with susceptibilityto type2 diabetes mellitus
-
Yasuda K, Miyake K, Horikawa Y., et al Variants in KCNQ1 are associated with susceptibilityto type2 diabetes mellitus. Nat Genet. 2008; 40: 1092-1097.
-
(2008)
Nat Genet.
, vol.40
, pp. 1092-1097
-
-
Yasuda, K.1
Miyake, K.2
Horikawa, Y.3
-
18
-
-
77957553197
-
A genome-wide association studyinthe Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B
-
Yamauchi T, Hara K, Maeda S., et al A genome-wide association studyinthe Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet. 2010; 42: 864-868.
-
(2010)
Nat Genet
, vol.42
, pp. 864-868
-
-
Yamauchi, T.1
Hara, K.2
Maeda, S.3
-
19
-
-
84863503465
-
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations
-
Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium
-
Imamura M, Maeda S, Yamauchi T., et al.; Diabetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet. 2012; 10: 1093-1113.
-
(2012)
Hum Mol Genet
, vol.10
, pp. 1093-1113
-
-
Imamura, M.1
Maeda, S.2
Yamauchi, T.3
-
20
-
-
78049438674
-
Identification of new genetic risk variants for type 2 diabetes
-
Shu XO, Long J, Cai Q., et al Identification of new genetic risk variants for type 2 diabetes. PLoS Genet. 2010; 6: e1001127.
-
(2010)
PLoS Genet
, vol.6
-
-
Shu, X.O.1
Long, J.2
Cai, Q.3
-
21
-
-
84868337361
-
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
-
Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEnT2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium
-
Morris AP, Voight BF, Teslovich T.M., et al.; Wellcome Trust Case Control Consortium; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) Investigators; Genetic Investigation of ANthropometric Traits (GIANT) Consortium; Asian Genetic Epidemiology Network-Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium, DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012; 44: 981-990.
-
(2012)
Nat Genet
, vol.44
, pp. 981-990
-
-
Morris, A.P.1
Voight, B.F.2
Teslovich, T.M.3
-
22
-
-
80755140152
-
A methodological perspective on genetic risk prediction studies in type 2 diabetes: Recommendations for future research
-
Willems SM, Mihaescu R, Sijbrands E.J., van Duijn CM, Janssens AC A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research. Curr Diab Rep. 2011; 11: 511-518.
-
(2011)
Curr Diab Rep
, vol.11
, pp. 511-518
-
-
Willems, S.M.1
Mihaescu, R.2
Sijbrands, E.J.3
Van Duijn, C.M.4
Janssens, A.C.5
-
23
-
-
55649105963
-
Clinical risk factors, DNA variants, and the development of type 2 diabetes
-
Lyssenko V, Jonsson A, Almgren P., et al Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008; 359: 2220-2232.
-
(2008)
N Engl J Med.
, vol.359
, pp. 2220-2232
-
-
Lyssenko, V.1
Jonsson, A.2
Almgren, P.3
-
24
-
-
56749101779
-
Genotype score in addition to common risk factors for prediction of type 2 diabetes
-
Meigs JB, Shrader P, Sullivan L.M., et al Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008; 359: 2208-2219.
-
(2008)
N Engl J Med.
, vol.359
, pp. 2208-2219
-
-
Meigs, J.B.1
Shrader, P.2
Sullivan, L.M.3
-
25
-
-
76249109928
-
Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
-
Talmud PJ, Hingorani AD, Cooper J.A., et al Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ. 2010; 340: b4838.
-
(2010)
BMJ
, vol.340
-
-
Talmud, P.J.1
Hingorani, A.D.2
Cooper, J.A.3
-
26
-
-
79951715822
-
DIAGRAM + investigators genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms
-
MAGIC Investigators
-
de Miguel-Yanes JM, Shrader P, Pencina MJ, et al.; MAGIC Investigators; DIAGRAM + Investigators Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care. 2011; 34: 121-125.
-
(2011)
Diabetes Care
, vol.34
, pp. 121-125
-
-
De Miguel-Yanes, J.M.1
Shrader, P.2
Pencina, M.J.3
-
27
-
-
66249089500
-
Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association
-
Miyake K, Yang W, Hara K., et al Construction of a prediction model for type 2 diabetes mellitus in the Japanese population based on 11 genes with strong evidence of the association. J Hum Genet. 2009; 54: 236-241.
-
(2009)
J Hum Genet
, vol.54
, pp. 236-241
-
-
Miyake, K.1
Yang, W.2
Hara, K.3
-
28
-
-
80054979509
-
Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: The shimanami health promoting program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score
-
Tabara Y, Osawa H, Kawamoto R., et al Genotype risk score of common susceptible variants for prediction of type 2 diabetes mellitus in Japanese: the Shimanami Health Promoting Program (J-SHIPP study). Development of type 2 diabetes mellitus and genotype risk score. Metabolism. 2011; 60: 1634-1640.
-
(2011)
Metabolism
, vol.60
, pp. 1634-1640
-
-
Tabara, Y.1
Osawa, H.2
Kawamoto, R.3
-
29
-
-
84864383698
-
Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals
-
Iwata M, Maeda S, Kamura Y., et al Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals. Diabetes Care. 2012; 35: 1763-1770.
-
(2012)
Diabetes Care
, vol.35
, pp. 1763-1770
-
-
Iwata, M.1
Maeda, S.2
Kamura, Y.3
-
30
-
-
84863670156
-
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared with obese cases
-
MAGIC; DIAGRAM Consortium; GIANT Consortium
-
Perry JR, Voight BF, Yengo L, et al.; MAGIC; DIAGRAM Consortium; GIANT Consortium. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared with obese cases. PLoS Genet. 2012; 8: e1002741.
-
(2012)
PLoS Genet
, vol.8
-
-
Perry, J.R.1
Voight, B.F.2
Yengo, L.3
-
31
-
-
84857249788
-
The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: A population based case-control study
-
Yamakawa-Kobayashi K., Natsume M, Aoki S., et al The combined effect of the T2DM susceptibility genes is an important risk factor for T2DM in non-obese Japanese: a population based case-control study. BMC Med Genet. 2012; 24: 13-11.
-
(2012)
BMC Med Genet
, vol.24
, pp. 13-11
-
-
Yamakawa-Kobayashi, K.1
Natsume, M.2
Aoki, S.3
-
32
-
-
80055035412
-
Association of new loci identified in european genome-wide association studies with susceptibility to type 2 diabetes in the Japanese
-
Ohshige T, Iwata M, Omori S., et al Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One. 2011; 6: e26911.
-
(2011)
PLoS One
, vol.6
-
-
Ohshige, T.1
Iwata, M.2
Omori, S.3
-
33
-
-
82455198579
-
Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population
-
Imamura M, Iwata M, Maegawa H., et al Genetic variants at CDC123/CAMK1D and SPRY2 are associated with susceptibility to type 2 diabetes in the Japanese population. Diabetologia. 2011; 54: 3071-3077.
-
(2011)
Diabetologia
, vol.54
, pp. 3071-3077
-
-
Imamura, M.1
Iwata, M.2
Maegawa, H.3
-
34
-
-
84866946023
-
A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population
-
Fukuda H, Imamura M, Tanaka Y., et al A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population. PLoS One. 2012; 7: e46263.
-
(2012)
PLoS One
, vol.7
-
-
Fukuda, H.1
Imamura, M.2
Tanaka, Y.3
-
35
-
-
0031851293
-
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
-
Alberti KG, Zimmet PZ Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998; 15: 539-553.
-
(1998)
Diabet Med.
, vol.15
, pp. 539-553
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
36
-
-
23844472598
-
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
-
Maeda S, Tsukada S, Kanazawa A., Set al Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J Hum Genet. 2005; 50: 283-292.
-
(2005)
J Hum Genet.
, vol.50
, pp. 283-292
-
-
Maeda, S.1
Tsukada, S.2
Kanazawa, A.S.3
-
37
-
-
84865693929
-
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
-
DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium
-
Scott RA, Lagou V, Welch R.P., et al.; DIAbetes Genetics Replication and Meta-analysis (DIAGRAM) Consortium. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012; 44: 991-1005.
-
(2012)
Nat Genet
, vol.44
, pp. 991-1005
-
-
Scott, R.A.1
Lagou, V.2
Welch, R.P.3
-
38
-
-
0032231375
-
Detecting marker-disease association by testing for hardy-weinberg disequilibrium at a marker locus
-
Nielsen DM, Ehm MG, Weir BS Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am J Hum Genet. 1998; 63: 1531-1540.
-
(1998)
Am J Hum Genet
, vol.63
, pp. 1531-1540
-
-
Nielsen, D.M.1
Ehm, M.G.2
Weir, B.S.3
-
39
-
-
0036856963
-
New criteria for 'obesity disease' in Japan
-
Examination Committee of Criteria for 'Obesity Disease' in Japan, Japan Society for the Study of Obesity
-
Examination Committee of Criteria for 'Obesity Disease' in Japan, Japan Society for the Study of Obesity. New criteria for 'obesity disease' in Japan. Circ J. 2002; 66: 987-992.
-
(2002)
Circ J
, vol.66
, pp. 987-992
-
-
-
40
-
-
34948845069
-
Association study of the genetic polymorphisms of the transcription factor 7-like2(TCF7L2) gene and type 2 diabetes in the Chinese population
-
Chang YC, Chang TJ, Jiang Y.D., et al Association study of the genetic polymorphisms of the transcription factor 7-like2(TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes. 2007; 56: 2631-2637.
-
(2007)
Diabetes
, vol.56
, pp. 2631-2637
-
-
Chang, Y.C.1
Chang, T.J.2
Jiang, Y.D.3
|