Metabolic and structural impairment of skeletal muscle in heart failure

Heart Failure Reviews

Volumn 18, Issue 5, 2013, Pages 623-630

  Zizola, Cynthia ^a   Schulze, P Christian ^a  

^a Department of Medicine   (United States)

Author keywords

Heart failure; Metabolism; Skeletal muscle

Indexed keywords

CALCIUM ION; GHRELIN; GROWTH FACTOR; INTERLEUKIN 6; SOMATOMEDIN C;

AEROBIC METABOLISM; CONFERENCE PAPER; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDURANCE TRAINING; HEART FAILURE; HEART FUNCTION; HISTOLOGY; HUMAN; METABOLIC DISORDER; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MUSCLE ATROPHY; MUSCLE CONTRACTION; MUSCLE EXCITATION; MUSCLE EXERCISE; MUSCLE FUNCTION; MUSCLE MASS; MUSCLE METABOLISM; MYOPATHY; MYOSITIS; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TREATMENT RESPONSE;

ANIMALS; ENERGY METABOLISM; HEART FAILURE; HUMANS; MUSCLE, SKELETAL; MYOCYTES, CARDIAC;

EID: 84885220975     PISSN: 13824147     EISSN: 15737322     Source Type: Journal    
DOI: 10.1007/s10741-012-9353-8     Document Type: Conference Paper

References (86)

1. Lunde PK, Sjaastad I, Schiotz Thorud HM, Sejersted OM (2001) Skeletal muscle disorders in heart failure. Acta Physiol Scand 171:277-294
2. Clark AL, Poole-Wilson PA, Coats AJ (1996) Exercise limitation in chronic heart failure: central role of the periphery. J Am Coll Cardiol 28:1092-1102
3. Mancini DM, Schwartz M, Ferraro N, Seestedt R, Chance B et al (1990) Effect of dobutamine on skeletal muscle metabolism in patients with congestive heart failure. Am J Cardiol 65:1121-1126
4. Maskin CS, Forman R, Sonnenblick EH, Frishman WH, LeJemtel TH (1983) Failure of dobutamine to increase exercise capacity despite hemodynamic improvement in severe chronic heart failure. Am J Cardiol 51:177-182
5. Wilson JR, Martin JL, Ferraro N (1984) Impaired skeletal muscle nutritive flow during exercise in patients with congestive heart failure: role of cardiac pump dysfunction as determined by the effect of dobutamine. Am J Cardiol 53:1308-1315
6. Zelis R, Delea CS, Coleman HN, Mason DT (1970) Arterial sodium content in experimental congestive heart failure. Circulation 41:213-216
7. Zelis R, Mason DT, Braunwald E (1968) A comparison of the effects of vasodilator stimuli on peripheral resistance vessels in normal subjects and in patients with congestive heart failure. J Clin Invest 47:960-970
8. Jondeau G, Katz SD, Zohman L, Goldberger M, McCarthy M et al (1992) Active skeletal muscle mass and cardiopulmonary reserve. Failure to attain peak aerobic capacity during maximal bicycle exercise in patients with severe congestive heart failure. Circulation 86:1351-1356
9. Mann DL, Reid MB (2003) Exercise training and skeletal muscle inflammation in chronic heart failure: feeling better about fatigue. J Am Coll Cardiol 42:869-872
10. Velloso CP (2008) Regulation of muscle mass by growth hormone and IGF-I. Br J Pharmacol 154:557-568
11. Drexler H, Riede U, Munzel T, Konig H, Funke E et al (1992) Alterations of skeletal muscle in chronic heart failure. Circulation 85:1751-1759
12. LeJemtel TH, Maskin CS, Lucido D, Chadwick BJ (1986) Failure to augment maximal limb blood flow in response to one-leg versus two-leg exercise in patients with severe heart failure. Circulation 74:245-251
13. Mancini DM, Henson D, LaManca J, Levine S (1992) Respiratory muscle function and dyspnea in patients with chronic congestive heart failure. Circulation 86:909-918
14. Minotti JR, Christoph I, Oka R, Weiner MW, Wells L et al (1991) Impaired skeletal muscle function in patients with congestive heart failure. Relationship to systemic exercise performance. J Clin Invest 88:2077-2082
15. Sullivan MJ, Green HJ, Cobb FR (1990) Skeletal muscle biochemistry and histology in ambulatory patients with long-term heart failure. Circulation 81:518-527
16. Chati Z, Zannad F, Jeandel C, Lherbier B, Escanye JM et al (1996) Physical deconditioning may be a mechanism for the skeletal muscle energy phosphate metabolism abnormalities in chronic heart failure. Am Heart J 131:560-566
17. Chati Z, Zannad F, Robin-Lherbier B, Escanye JM, Jeandel C et al (1994) Contribution of specific skeletal muscle metabolic abnormalities to limitation of exercise capacity in patients with chronic heart failure: a phosphorus 31 nuclear magnetic resonance study. Am Heart J 128:781-792
18. Mettauer B, Zoll J, Sanchez H, Lampert E, Ribera F et al (2001) Oxidative capacity of skeletal muscle in heart failure patients versus sedentary or active control subjects. J Am Coll Cardiol 38:947-954
19. Simonini A, Long CS, Dudley GA, Yue P, McElhinny J et al (1996) Heart failure in rats causes changes in skeletal muscle morphology and gene expression that are not explained by reduced activity. Circ Res 79:128-136
20. Troosters T, Gosselink R, Decramer M (2004) Chronic obstructive pulmonary disease and chronic heart failure: two muscle diseases? J Cardiopulm Rehabil 24:137-145
21. Mann DL (2002) Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res 91:988-998
22. Opie LH, Knuuti J (2009) The adrenergic-fatty acid load in heart failure. J Am Coll Cardiol 54:1637-1646
23. Doehner W, Rauchhaus M, Ponikowski P, Godsland IF, von Haehling S et al (2005) Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure. J Am Coll Cardiol 46:1019-1026
24. Doehner W, von Haehling S, Anker SD (2008) Insulin resistance in chronic heart failure. J Am Coll Cardiol 52:239
25. Gollnick PD, Armstrong RB, Saubert CW IV, Piehl K, Saltin B (1972) Enzyme activity and fiber composition in skeletal muscle of untrained and trained men. J Appl Physiol 33:312-319
26. Schiaffino S, Reggiani C (1996) Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev 76:371-423
27. Schaufelberger M, Eriksson BO, Grimby G, Held P, Swedberg K (1995) Skeletal muscle fiber composition and capillarization in patients with chronic heart failure: relation to exercise capacity and central hemodynamics. J Card Fail 1:267-272
28. Szentesi P, Bekedam MA, van Beek-Harmsen BJ, van der Laarse WJ, Zaremba R et al (2005) Depression of force production and ATPase activity in different types of human skeletal muscle fibers from patients with chronic heart failure. J Appl Physiol 99:2189-2195
29. Opasich C, Aquilani R, Dossena M, Foppa P, Catapano M et al (1996) Biochemical analysis of muscle biopsy in overnight fasting patients with severe chronic heart failure. Eur Heart J 17:1686-1693
30. Miller MS, Vanburen P, Lewinter MM, Lecker SH, Selby DE et al (2009) Mechanisms underlying skeletal muscle weakness in human heart failure: alterations in single fiber myosin protein content and function. Circ Heart Fail 2:700-706
31. Sabbah HN, Shimoyama H, Sharov VG, Kono T, Gupta RC et al (1996) Effects of ACE inhibition and beta-blockade on skeletal muscle fiber types in dogs with moderate heart failure. Am J Physiol 270:H115-H120
32. Schieffer B, Wollert KC, Berchtold M, Saal K, Schieffer E et al (1995) Development and prevention of skeletal muscle structural alterations after experimental myocardial infarction. Am J Physiol 269:H1507-H1513
33. Vescovo G, Dalla LL, Serafini F, Leprotti C, Facchin L et al (1998) Improved exercise tolerance after losartan and enalapril in heart failure: correlation with changes in skeletal muscle myosin heavy chain composition. Circulation 98:1742-1749
34. Fregosi RF, Seals DR (1993) Hypoxic potentiation of the ventilatory response to dynamic forearm exercise. J Appl Physiol 74:2365-2372
35. Lipkin DP, Jones DA, Round JM, Poole-Wilson PA (1988) Abnormalities of skeletal muscle in patients with chronic heart failure. Int J Cardiol 18:187-195
36. Mancini DM, Coyle E, Coggan A, Beltz J, Ferraro N et al (1989) Contribution of intrinsic skeletal muscle changes to 31P NMR skeletal muscle metabolic abnormalities in patients with chronic heart failure. Circulation 80:1338-1346
37. McCully K, Mancini D, Levine S (1999) Nuclear magnetic resonance spectroscopy: its role in providing valuable insight into diverse clinical problems. Chest 116:1434-1441
38. Oelberg DA, Evans AB, Hrovat MI, Pappagianopoulos PP, Patz S et al (1998) Skeletal muscle chemoreflex and pHi in exercise ventilatory control. J Appl Physiol 84:676-682
39. Massie B, Conway M, Yonge R, Frostick S, Ledingham J et al (1987) Skeletal muscle metabolism in patients with congestive heart failure: relation to clinical severity and blood flow. Circulation 76:1009-1019
40. Wiener DH, Fink LI, Maris J, Jones RA, Chance B et al (1986) Abnormal skeletal muscle bioenergetics during exercise in patients with heart failure: role of reduced muscle blood flow. Circulation 73:1127-1136
41. Lang CC, Chomsky DB, Rayos G, Yeoh TK, Wilson JR (1997) Skeletal muscle mass and exercise performance in stable ambulatory patients with heart failure. J Appl Physiol 82:257-261
42. Katz SD, Maskin C, Jondeau G, Cocke T, Berkowitz R et al (2000) Near-maximal fractional oxygen extraction by active skeletal muscle in patients with chronic heart failure. J Appl Physiol 88:2138-2142
43. Peters DG, Mitchell HL, McCune SA, Park S, Williams JH et al (1997) Skeletal muscle sarcoplasmic reticulum Ca(2+)-ATPase gene expression in congestive heart failure. Circ Res 81:703-710
44. Bellinger AM, Mongillo M, Marks AR (2008) Stressed out: the skeletal muscle ryanodine receptor as a target of stress. J Clin Invest 118:445-453
45. Lunde PK, Dahlstedt AJ, Bruton JD, Lannergren J, Thoren P et al (2001) Contraction and intracellular Ca(2+) handling in isolated skeletal muscle of rats with congestive heart failure. Circ Res 88:1299-1305
46. Mancini DM, Walter G, Reichek N, Lenkinski R, McCully KK et al (1992) Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure. Circulation 85:1364-1373
47. Williams AD, Selig S, Hare DL, Hayes A, Krum H et al (2004) Reduced exercise tolerance in CHF may be related to factors other than impaired skeletal muscle oxidative capacity. J Card Fail 10:141-148
48. Schrepper A, Schwarzer M, Schope M, Amorim PA, Doenst T (2012) Biphasic response of skeletal muscle mitochondria to chronic cardiac pressure overload - role of respiratory chain complex activity. J Mol Cell Cardiol 52:125-135
49. Mancini DM, Ferraro N, Tuchler M, Chance B, Wilson JR (1988) Detection of abnormal calf muscle metabolism in patients with heart failure using phosphorus-31 nuclear magnetic resonance. Am J Cardiol 62:1234-1240
50. Witte KK, Clark AL (2007) Why does chronic heart failure cause breathlessness and fatigue? Prog Cardiovasc Dis 49:366-384
51. Duscha BD, Schulze PC, Robbins JL, Forman DE (2008) Implications of chronic heart failure on peripheral vasculature and skeletal muscle before and after exercise training. Heart Fail Rev 13:21-37
52. Miller MS, VanBuren P, LeWinter MM, Braddock JM, Ades PA et al (2010) Chronic heart failure decreases cross-bridge kinetics in single skeletal muscle fibres from humans. J Physiol 588:4039-4053
53. Okada Y, Toth MJ, VanBuren P (2008) Skeletal muscle contractile protein function is preserved in human heart failure. J Appl Physiol 104:952-957
54. Le Jemtel TH, Padeletti M, Jelic S (2007) Diagnostic and therapeutic challenges in patients with coexistent chronic obstructive pulmonary disease and chronic heart failure. J Am Coll Cardiol 49:171-180
55. Song YH, Li Y, Du J, Mitch WE, Rosenthal N et al (2005) Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest 115:451-458
56. Du J, Wang X, Miereles C, Bailey JL, Debigare R et al (2004) Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113:115-123
57. Schulze PC, Fang J, Kassik KA, Gannon J, Cupesi M et al (2005) Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Circ Res 97:418-426
58. Song YH, Li Y, Du J, Mitch WE, Rosenthal N et al (2005) Muscle-specific expression of IGF-1 blocks angiotensin II-induced skeletal muscle wasting. J Clin Invest 115:451-458
59. Pedersen BK, Febbraio MA (2008) Muscle as an endocrine organ: focus on muscle-derived interleukin-6. Physiol Rev 88:1379-1406
60. Caminiti G, Volterrani M, Iellamo F, Marazzi G, Massaro R et al (2009) Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure a double-blind, placebo-controlled, randomized study. J Am Coll Cardiol 54:919-927
61. Jankowska EA, Biel B, Majda J, Szklarska A, Lopuszanska M et al (2006) Anabolic deficiency in men with chronic heart failure: prevalence and detrimental impact on survival. Circulation 114:1829-1837
62. Sacca L (2009) Heart failure as a multiple hormonal deficiency syndrome. Circ Heart Fail 2:151-156
63. Aukrust P, Ueland T, Gullestad L, Yndestad A (2009) Testosterone: a novel therapeutic approach in chronic heart failure? J Am Coll Cardiol 54:928-929
64. Bhasin S, Woodhouse L, Storer TW (2001) Proof of the effect of testosterone on skeletal muscle. J Endocrinol 170:27-38
65. Heineke J, Auger-Messier M, Xu J, Sargent M, York A et al (2010) Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation 121:419-425
66. George I, Bish LT, Kamalakkannan G, Petrilli CM, Oz MC et al (2010) Myostatin activation in patients with advanced heart failure and after mechanical unloading. Eur J Heart Fail 12:444-453
67. Yndestad A, Ueland T, Oie E, Florholmen G, Halvorsen B et al (2004) Elevated levels of activin A in heart failure: potential role in myocardial remodeling. Circulation 109:1379-1385
68. Ferrari R, Bachetti T, Confortini R, Opasich C, Febo O et al (1995) Tumor necrosis factor soluble receptors in patients with various degrees of congestive heart failure. Circulation 92:1479-1486
69. Testa M, Yeh M, Lee P, Fanelli R, Loperfido F et al (1996) Circulating levels of cytokines and their endogenous modulators in patients with mild to severe congestive heart failure due to coronary artery disease or hypertension. J Am Coll Cardiol 28:964-971
70. Gielen S, Adams V, Mobius-Winkler S, Linke A, Erbs S et al (2003) Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. J Am Coll Cardiol 42:861-868
71. Mourkioti F, Rosenthal N (2008) NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases. J Mol Med 86:747-759
72. Janssen SP, Gayan-Ramirez G, Van den Bergh A, Herijgers P, Maes K et al (2005) Interleukin-6 causes myocardial failure and skeletal muscle atrophy in rats. Circulation 111:996-1005
73. Adamopoulos S, Coats AJ, Brunotte F, Arnolda L, Meyer T et al (1993) Physical training improves skeletal muscle metabolism in patients with chronic heart failure. J Am Coll Cardiol 21:1101-1106
74. Hambrecht R, Fiehn E, Yu J, Niebauer J, Weigl C et al (1997) Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure. J Am Coll Cardiol 29:1067-1073
75. Hambrecht R, Schulze PC, Gielen S, Linke A, Mobius-Winkler S et al (2005) Effects of exercise training on insulin-like growth factor-I expression in the skeletal muscle of non-cachectic patients with chronic heart failure. Eur J Cardiovasc Prev Rehabil 12:401-406
76. Williams AD, Carey MF, Selig S, Hayes A, Krum H et al (2007) Circuit resistance training in chronic heart failure improves skeletal muscle mitochondrial ATP production rate-a randomized controlled trial. J Card Fail 13:79-85
77. Shahzad K, Chokshi A, Schulze PC (2011) Supplementation of glutamine and omega-3 polyunsaturated fatty acids as a novel therapeutic intervention targeting metabolic dysfunction and exercise intolerance in patients with heart failure. Curr Clin Pharmacol 6:288-294
78. Nodari S, Triggiani M, Campia U, Manerba A, Milesi G et al (2011) Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol 57:870-879
79. Gissi HFI, Tavazzi L, Maggioni AP, Marchioli R, Barlera S et al (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 372:1223-1230
80. Schulze PC, Fang J, Kassik KA, Gannon J, Cupesi M et al (2005) Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction. Circ Res 97:418-426
81. Nagaya N, Moriya J, Yasumura Y, Uematsu M, Ono F et al (2004) Effects of ghrelin administration on left ventricular function, exercise capacity, and muscle wasting in patients with chronic heart failure. Circulation 110:3674-3679
82. Nagaya N, Itoh T, Murakami S, Oya H, Uematsu M et al (2005) Treatment of cachexia with ghrelin in patients with COPD. Chest 128:1187-1193
83. Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D et al (2001) Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 22:791-797
84. Hambrecht R, Fiehn E, Niebauer J, Dieterle T, Offner B et al (1995) Effects of physical exercise on oxidative enzyme activity and fiber type distribution in skeletal muscle of patients with chronic failure. J Am Coll Cardiol 29:1067-1073
85. Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C et al (1998) Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 98:2709-2715
86. Hambrecht R, Gielen S, Linke A, Fiehn E, Yu J et al (2000) Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure. A randomised trial. JAMA 283:3095-3101