Length polymorphism in Heme Oxygenase-1 and cardiovascular events and mortality in hemodialysis patients

Clinical Journal of the American Society of Nephrology

Volumn 8, Issue 10, 2013, Pages 1756-1763

  Chen, Yu Hsin ^a,b   Hung, Szu Chun ^c   Tarng, Der Cherng ^a,b  

^a TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; HEME OXYGENASE 1; MALONALDEHYDE;

ADULT; ALLELE; ARTICLE; BLOOD ANALYSIS; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DNA EXTRACTION; DNA POLYMORPHISM; FEMALE; FOLLOW UP; GENE; GENOTYPE; GUANOSINE THYMIDINE DINUCLEOTIDE REPEAT; HEME OXYGENASE 1 GENE; HEMODIALYSIS; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MORTALITY; OUTCOME ASSESSMENT; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROSPECTIVE STUDY;

ADULT; AGED; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; FEMALE; GENOTYPE; HEME OXYGENASE-1; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PROPORTIONAL HAZARDS MODELS; RENAL DIALYSIS; RENAL INSUFFICIENCY, CHRONIC;

EID: 84885211823     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.01110113     Document Type: Article

References (29)

1. de Jager DJ, Grootendorst DC, Jager KJ, van Dijk PC, Tomas LM, Ansell D, Collart F, Finne P, Heaf JG, De Meester J, Wetzels JF, Rosendaal FR, Dekker FW: Cardiovascular and noncardiovascular mortality among patients starting dialysis. JAMA 302: 1782-1789, 2009
2. Clermont G, Lecour S, Lahet J, Siohan P, Vergely C, Chevet D, Rifle G, Rochette L: Alteration in plasma antioxidant capacities in chronic renal failure and hemodialysis patients: A possible explanation for the increased cardiovascular risk in these patients. Cardiovasc Res 47: 618-623, 2000
3. Maines MD: Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J 2: 2557-2568, 1988
4. Idriss NK, Blann AD, Lip GY: Hemoxygenase-1 in cardiovascular disease. J Am Coll Cardiol 52: 971-978, 2008
5. Abraham NG, Kappas A: Heme oxygenase and the cardiovascular-renal system. Free Radic Biol Med 39: 1-25, 2005
6. Kutty RK, Kutty G, Rodriguez IR, Chader GJ, Wiggert B: Chromosomal localization of the human heme oxygenase genes: Heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3. Genomics 20: 513-516, 1994
7. Exner M, Schillinger M, Minar E, Mlekusch W, Schlerka G, Haumer M, Mannhalter C, Wagner O: Heme oxygenase-1 gene promoter microsatellite polymorphism is associated with restenosis after percutaneous transluminal angioplasty. J Endovasc Ther 8: 433-440, 2001
8. Chen YH, Lin SJ, Lin MW, Tsai HL, Kuo SS, Chen JW, Charng MJ, Wu TC, Chen LC, Ding YA, Pan WH, Jou YS, Chau LY: Microsatellite polymorphism in promoter of heme oxygenase-1 gene is associated with susceptibility to coronary artery disease in type 2 diabetic patients. Hum Genet 111: 1-8, 2002
9. Kaneda H, Ohno M, Taguchi J, Togo M, Hashimoto H, Ogasawara K, Aizawa T, Ishizaka N, Nagai R: Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Arterioscler Thromb Vasc Biol 22: 1680-1685, 2002
10. Dick P, Schillinger M, Minar E, Mlekusch W, Amighi J, Sabeti S, Schlager O, Raith M, Endler G, Mannhalter C, Wagner O, Exner M: Haem oxygenase-1 genotype and cardiovascular adverse events in patients with peripheral artery disease. Eur J Clin Invest 35: 731-737, 2005
11. Wu MM, Chiou HY, Chen CL, Wang YH, Hsieh YC, Lien LM, Lee TC, Chen CJ: GT-repeat polymorphism in the heme oxygenase-1 gene promoter is associated with cardiovascular mortality risk in an arsenic-exposed population in northeastern Taiwan. Toxicol Appl Pharmacol 248: 226-233, 2010
12. Lin CC, Yang WC, Lin SJ, Chen TW, Lee WS, Chang CF, Lee PC, Lee SD, Su TS, Fann CS, Chung MY: Length polymorphism in heme oxygenase-1 is associated with arteriovenous fistula patency in hemodialysis patients. Kidney Int 69: 165-172, 2006
13. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, Kusek JW, Van Lente F; Chronic Kidney Disease Epidemiology Collaboration: Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 145: 247-254, 2006
14. Pritchard JK, Rosenberg NA: Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet 65: 220-228, 1999
15. Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P: Plasma malondialdehyde as biomarker for oxidative stress: Reference interval and effects of life-style factors. Clin Chem 43: 1209-1214, 1997
16. Daugirdas JT: Second generation logarithmic estimates of single-pool variable volume Kt/V: An analysis of error. J Am Soc Nephrol 4: 1205-1213, 1993
17. Kimpara T, Takeda A, Watanabe K, Itoyama Y, Ikawa S, Watanabe M, Arai H, Sasaki H, Higuchi S, Okita N, Takase S, Saito H, Takahashi K, Shibahara S: Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease. Hum Genet 100: 145-147, 1997
18. Lublinghoff N, Winkler K, Winkelmann BR, Seelhorst U, Wellnitz B, Boehm BO, Marz W, Hoffmann MM: Genetic variants of the promoter of the heme oxygenase-1 gene and their influence on cardiovascular disease (the Ludwigshafen Risk and Cardiovascular Health study). BMC Med Genet 10: 36, 2009
19. Yang WC, Hwang SJ; Taiwan Society of Nephrology: Incidence, prevalence and mortality trends of dialysis end-stage renal disease in Taiwan from 1990 to 2001: The impact of national health insurance. Nephrol Dial Transplant 23: 3977-3982, 2008
20. Schillinger M, Exner M, Minar E, Mlekusch W, Mullner M, Mannhalter C, Bach FH, Wagner O: Heme oxygenase-1 genotype and restenosis after balloon angioplasty: A novel vascular protective factor. J Am Coll Cardiol 43: 950-957, 2004
21. Katan MB: Apolipoprotein E isoforms, serum cholesterol, and cancer. Lancet 1: 507-508, 1986
22. Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AM: Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 6: 422-428, 2000
23. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN: Bilirubin is an antioxidant of possible physiological importance. Science 235: 1043-1046, 1987
24. Willis D, Moore AR, Frederick R, Willoughby DA: Heme oxygenase: A novel target for the modulation of the inflammatory response. Nat Med 2: 87-90, 1996
25. Lavrovsky Y, Schwartzman ML, Levere RD, Kappas A, Abraham NG: Identification of binding sites for transcription factors NF-k B and AP-2 in the promoter region of the human heme oxygenase 1 gene. Proc Natl Acad Sci U S A 91: 5987-5991, 1994
26. Chen YH, Chau LY, Lin MW, Chen LC, Yo MH, Chen JW, Lin SJ: Heme oxygenase-1 gene promotor microsatellite polymorphism is associated with angiographic restenosis after coronary stenting. Eur Heart J 25: 39-47, 2004
27. Wu MM, Chiou HY, Lee TC, Chen CL, Hsu LI, Wang YH, Huang WL, Hsieh YC, Yang TY, Lee CY, Yip PK, Wang CH, Hsueh YM, Chen CJ: GT-repeat polymorphism in the heme oxygenase-1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure. J Biomed Sci 17: 70, 2010
28. Wu MM, Chiou HY, Chen CL, Hsu LI, Lien LM, Wang CH, Hsieh YC, Wang YH, Hsueh YM, Lee TC, Cheng WF, Chen CJ: Association of heme oxygenase-1 GT-repeat polymorphism with blood pressure phenotypes and its relevance to future cardiovascular mortality risk: An observation based on arsenic-exposed individuals. Atherosclerosis 219: 704-708, 2011
29. Bai CH, Chen JR, Chiu HC, Chou CC, Chau LY, Pan WH: Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients. J Biomed Sci 17: 12, 2010