Novel 3-nitro-1H-1,2,4-triazole-based piperazines and 2-amino-1,3- benzothiazoles as antichagasic agents

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6600-6607

  Papadopoulou, Maria V ^a   Bloomer, William D ^a   Rosenzweig, Howard S ^b   Kaiser, Marcel ^c,d   Chatelain, Eric ^e   Ioset, Jean Robert ^e  

^a NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^b Oakton Community College   (United States)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e Drugs for Neglected Diseases Initiative DNDi   (Switzerland)

Author keywords

Antitrypanosomal agents; Benzothiazoles; Chagas disease; Nitrotriazoles; Piperazines

Indexed keywords

1 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL] 4 (PYRIDIN 2 YL)PIPERAZINE DIHYDROCHLORIDE; 1 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL] 4 (PYRIDIN 4 YL)PIPERAZINE; 1 [3,4 DICHLOROPHENYL] 4 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL]PIPERAZINE DIHYDROCHLORIDE; 1 [4 METHOXYPHENYL] 4 [3 (2 NITRO 1H IMIDAZOL 1 YL)PROPYL]PIPERAZINE DIHYDROCHLORIDE; 1 [4 METHOXYPHENYL] 4 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL]PIPERAZINE DIHYDROCHLORIDE; 1 [4 METHYLPHENYL] 4 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL]PIPERAZINE DIHYDROCHLORIDE; 1 [[3,4 DICHLOROPHENYL]METHYL] 4 [3 (2 NITRO 1H IMIDAZOL 1 YL)PROPYL]PIPERAZINE DIHYDROCHLORIDE; 1 [[3,4 DICHLOROPHENYL]METHYL] 4 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL]PIPERAZINE DIHYDROCHLORIDE; 1 CYCLOPROPANECARBONYL 4 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL]PIPERAZINE HYDROCHLORIDE; 2 [4 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL]PIPERAZIN 1 YL]BENZONITRILE DIHYDROCHLORIDE; 2 [4 [3 (3 NITRO 1H 1,2,4 TRIAZOL 1 YL)PROPYL]PIPERAZIN 1 YL]PYRIMIDINE DIHYDROCHLORIDE; 2 AMINO 1,3 BENZOTHIAZOLE DERIVATIVE; 3 NITRO 1H 1,2,4 TRIAZOLE PIPERAZINE DERIVATIVE; 6 CHLORO N [3 [2 NITRO 1H IMIDAZOL 1 YL]PROPYL] 1,3 BENZOTHIAZOL 2 AMINE; 6 CHLORO N [3 [3 NITRO 1H 1,2,4 TRIAZOL 1 YL]PROPYL] 1,3 BENZOTHIAZOL 2 AMINE; 6 CHLORO N [4 [2 NITRO 1H IMIDAZOL 1 YL]BUTYL] 1,3 BENZOTHIAZOL 2 AMINE; 6 CHLORO N [4 [3 NITRO 1H 1,2,4 TRIAZOL 1 YL]BUTYL] 1,3 BENZOTHIAZOL 2 AMINE; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; BENZOTHIAZOLE DERIVATIVE; N [3 [2 NITRO 1H IMIDAZOL 1 YL]PROPYL] 1,3 BENZOTHIAZOL 2 AMINE; N [3 [3 NITRO 1H 1,2,4 TRIAZOL 1 YL]PROPYL] 1,3 BENZOTHIAZOL 2 AMINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHAGAS DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; LEISHMANIA DONOVANI; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY; TRYPANOCIDAL ACTIVITY; TRYPANOSOMA CRUZI; TRYPANOSOMA RHODESIENSE; TRYPOMASTIGOTE;

LEISHMANIA DONOVANI; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

ANTITRYPANOSOMAL AGENTS; BENZNIDAZOLE (N-BENZYL-2-(2-NITRO-1H-IMIDAZOL-1-YL)ACETAMIDE); BENZOTHIAZOLES; BNZ; CHAGAS DISEASE; CONCENTRATION FOR 50% GROWTH INHIBITION; HAT; HUMAN AFRICAN TRYPANOSOMIASIS; IC(50); NFX; NIFURTIMOX (4-(5-NITROFURFURYLINDENAMINO)-3-METHYLTHIO-MORPHOLINE-1,1-DIOXIDE); NITROTRIAZOLES; NTR; PIPERAZINES; SARS; SELECTIVITY INDEX; SI; STRUCTURE-ACTIVITY RELATIONSHIPS; T. BRUCEI; T. BRUCEI NTR; T. CRUZI; TBNTR; TDR; TROPICAL DISEASES RESEARCH (HTTP://WWW.WHO.INT/TDR/EN/); TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TYPE I NITROREDUCTASE;

ANIMALS; BENZOTHIAZOLES; CELL LINE; CELL SURVIVAL; LEISHMANIA DONOVANI; PIPERAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMA CRUZI;

EID: 84885182984     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.022     Document Type: Article

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