SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 3986-3991

Synthesis and structure-activity relationships of nitrobenzyl phosphoramide mustards as nitroreductase-activated prodrugs

(12) Hu, Longqin a,b Wu, Xinghua a Han, Jiye a Chen, Lin a Vass, Simon O c Browne, Patrick d Hall, Belinda S e Bot, Christopher e Gobalakrishnapillai, Vithurshaa e Searle, Peter F c Knox, Richard J d Wilkinson, Shane R e

a RUTGERS UNIVERSITY (United States)

b RUTGERS CANCER INSTITUTE OF NEW JERSEY (United States)

c UNIVERSITY OF BIRMINGHAM (United Kingdom)

d Morvus Technology Ltd (United Kingdom)

e QUEEN MARY UNIVERSITY OF LONDON (United Kingdom)

Author keywords

Antiproliferative; Leishmania; Nitroreductase; Phosphoramide mustard; Prodrug; Trypanosoma

Indexed keywords

4 NITROBENZYL CARBAMATE PHOSPHORAMIDE MUSTARD; 4 NITROBENZYL PHOSPHORAMIDE BROMOMUSTARD; 4 NITROBENZYL PHOSPHORAMIDE MUSTARD; 5 NITROPYRID 2 YL METHYL PHOSPHORAMIDE MUSTARD; ANTILEISHMANIAL AGENT; ANTINEOPLASTIC AGENT; ANTIPARASITIC AGENT; BENZYL PHOSPHORAMIDE MUSTARD; HALOGEN; NITROREDUCTASE; PHOSPHORAMIDE MUSTARD; PRODRUG; SULFAMIDITE MUSTARD; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRASSICA; CELL MEMBRANE; DIASTEREOISOMER; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG RELEASE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE DIRECTED ENZYME PRODRUG THERAPY; IC 50; KINETOPLASTIDA; MAMMAL CELL; NONHUMAN; ONE POT SYNTHESIS; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

ANIMALS; CELL PROLIFERATION; ESCHERICHIA COLI; HUMANS; INHIBITORY CONCENTRATION 50; LEISHMANIA; NITROGEN MUSTARD COMPOUNDS; NITROREDUCTASES; ORGANOPHOSPHORUS COMPOUNDS; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BRASSICACEAE; ESCHERICHIA COLI; MAMMALIA; TRYPANOSOMA; TRYPANOSOMATIDAE;

EID: 79958709444 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.05.009 Document Type: Article

Times cited : (41)

References (23)

1
- 39349084237
- Kratz, F.; Muller, I. A.; Ryppa, C.; Warnecke, A. ChemMedChem 2008, 3, 20.
- (2008) ChemMedChem , vol.3 , pp. 20
- Kratz, F.¹ Muller, I.A.² Ryppa, C.³ Warnecke, A.⁴

2
- 16544364403
- Hu, L. IDrugs 2004, 7, 736.
- (2004) IDrugs , vol.7 , pp. 736
- Hu, L.¹

3
- 0035253404
- Huang, P. S.; Oliffa, A. Curr. Opin. Genet. Dev. 2001, 11, 104.
- (2001) Curr. Opin. Genet. Dev. , vol.11 , pp. 104
- Huang, P.S.¹ Oliffa, A.²

4
- 6344282432
- Denny, W. A. Aust. J. Chem. 2004, 57, 821.
- (2004) Aust. J. Chem. , vol.57 , pp. 821
- Denny, W.A.¹

5
- 0030589537
- Sherwood, R. F. Adv. Drug Deliv. Rev. 1996, 22, 269.
- (1996) Adv. Drug Deliv. Rev. , vol.22 , pp. 269
- Sherwood, R.F.¹

6
- 0003962432
- Kluwer Academic/Plenum: New York
- Enzyme-prodrug strategies for cancer therapy; Melton, R. G., Knox, R. J., Eds.; Kluwer Academic/Plenum: New York, 1999.
- (1999) Enzyme-prodrug Strategies for Cancer Therapy
- Melton, R.G.¹ Knox, R.J.²

7
- 0034605189
- Jones, G. B.; Mitchell, M. O.; Weinberg, J. S.; D'Amico, A. V.; Bubley, G. J. Bioorg. Med. Chem. Lett. 2000, 10, 1987.
- (2000) Bioorg. Med. Chem. Lett. , vol.10 , pp. 1987
- Jones, G.B.¹ Mitchell, M.O.² Weinberg, J.S.³ D'Amico, A.V.⁴ Bubley, G.J.⁵

8
- 41649103896
- Atkinson, J. M.; Siller, C. S.; Gill, J. H. Br. J. Pharmacol. 2008, 153, 1344.
- (2008) Br. J. Pharmacol. , vol.153 , pp. 1344
- Atkinson, J.M.¹ Siller, C.S.² Gill, J.H.³

9
- 58849153727
- Chen, Y.; Hu, L. Med. Res. Rev. 2009, 29, 29.
- (2009) Med. Res. Rev. , vol.29 , pp. 29
- Chen, Y.¹ Hu, L.²

10
- 0031558240
- Niculescu-Duvaz, I.; Springer, C. J. Adv. Drug Deliv. Rev. 1997, 26, 151.
- (1997) Adv. Drug Deliv. Rev. , Issue.26 , pp. 151
- Niculescu-Duvaz, I.¹ Springer, C.J.²

11
- 0028090161
- Mauger, A. B.; Burke, P. J.; Somani, H. H.; Friedlos, F.; Knox, R. J. J. Med. Chem. 1994, 37, 3452.
- (1994) J. Med. Chem. , vol.37 , pp. 3452
- Mauger, A.B.¹ Burke, P.J.² Somani, H.H.³ Friedlos, F.⁴ Knox, R.J.⁵

12
- 4444318140
- McKeown, S. R.; Ward, C.; Robson, T. Curr. Opin. Mol. Ther. 2004, 6, 421.
- (2004) Curr. Opin. Mol. Ther. , vol.6 , pp. 421
- McKeown, S.R.¹ Ward, C.² Robson, T.³

13
- 9344252858
- Searle, P. F.; Chen, M. J.; Hu, L. Q.; Race, P. R.; Lovering, A. L.; Grove, J. I.; Guise, C.; Jaberipour, M.; James, N. D.; Mautner, V.; Young, L. S.; Kerr, D. J.; Mountain, A.; White, S. A.; Hyde, E. I. Clin. Exp. Pharmacol. Physiol. 2004, 31, 811.
- (2004) Clin. Exp. Pharmacol. Physiol. , vol.31 , pp. 811
- Searle, P.F.¹ Chen, M.J.² Hu, L.Q.³ Race, P.R.⁴ Lovering, A.L.⁵ Grove, J.I.⁶ Guise, C.⁷ Jaberipour, M.⁸ James, N.D.⁹ Mautner, V.¹⁰ Young, L.S.¹¹ Kerr, D.J.¹² Mountain, A.¹³ White, S.A.¹⁴ Hyde, E.I.¹⁵

14
- 0036015563
- Denny, W. A. Curr. Pharm. Des. 2002, 8, 1349.
- (2002) Curr. Pharm. Des. , vol.8 , pp. 1349
- Denny, W.A.¹

15
- 0031974255
- Friedlos, F.; Court, S.; Ford, M.; Denny, W. A.; Springer, C. Gene Ther. 1998, 5, 105.
- (1998) Gene Ther. , vol.5 , pp. 105
- Friedlos, F.¹ Court, S.² Ford, M.³ Denny, W.A.⁴ Springer, C.⁵

16
- 0141790765
- Johansson, E.; Parkinson, G. N.; Denny, W. A.; Neidle, S. J. Med. Chem. 2003, 46, 4009.
- (2003) J. Med. Chem. , vol.46 , pp. 4009
- Johansson, E.¹ Parkinson, G.N.² Denny, W.A.³ Neidle, S.⁴

17
- 0242299595
- Hu, L.; Yu, C.; Jiang, Y.; Han, J.; Li, Z.; Browne, P.; Race, P. R.; Knox, R. J.; Searle, P. F.; Hyde, E. I. J. Med. Chem. 2003, 46, 4818.
- (2003) J. Med. Chem. , vol.46 , pp. 4818
- Hu, L.¹ Yu, C.² Jiang, Y.³ Han, J.⁴ Li, Z.⁵ Browne, P.⁶ Race, P.R.⁷ Knox, R.J.⁸ Searle, P.F.⁹ Hyde, E.I.¹⁰

18
- 42449155428
- Wilkinson, S. R.; Taylor, M. C.; Horn, D.; Kelly, J. M.; Cheeseman, I. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 5022.
- (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 5022
- Wilkinson, S.R.¹ Taylor, M.C.² Horn, D.³ Kelly, J.M.⁴ Cheeseman, I.⁵

19
- 56649117558
- Kashanian, J.; Hakimian, P.; Blute, M., Jr.; Wong, J.; Khanna, H.; Wise, G.; Shabsigh, R. BJU Int. 2008, 102, 1634.
- (2008) BJU Int. , vol.102 , pp. 1634
- Kashanian, J.¹ Hakimian, P.² Blute Jr., M.³ Wong, J.⁴ Khanna, H.⁵ Wise, G.⁶ Shabsigh, R.⁷

20
- 77149159732
- Hall, B. S.; Wu, X.; Hu, L.; Wilkinson, S. R. Antimicrob. Agents Chemother. 2010, 54, 1193.
- (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1193
- Hall, B.S.¹ Wu, X.² Hu, L.³ Wilkinson, S.R.⁴

21
- 33745827010
- Jiang, Y.; Han, J.; Yu, C.; Vass, S. O.; Searle, P. F.; Browne, P.; Knox, R. J.; Hu, L. J. Med. Chem. 2006, 49, 4333.
- (2006) J. Med. Chem. , vol.49 , pp. 4333
- Jiang, Y.¹ Han, J.² Yu, C.³ Vass, S.O.⁴ Searle, P.F.⁵ Browne, P.⁶ Knox, R.J.⁷ Hu, L.⁸

22
- 0032516304
- McGeary, R. P. Tetrahedron Lett. 1998, 39, 3319.
- (1998) Tetrahedron Lett. , vol.39 , pp. 3319
- McGeary, R.P.¹

23
- 0034212605
- Borch, R. F.; Liu, J. W.; Schmidt, J. P.; Marakovits, J. T.; Joswig, C.; Gipp, J. J.; Mulcahy, R. T. J. Med. Chem. 2000, 43, 2258.
- (2000) J. Med. Chem. , vol.43 , pp. 2258
- Borch, R.F.¹ Liu, J.W.² Schmidt, J.P.³ Marakovits, J.T.⁴ Joswig, C.⁵ Gipp, J.J.⁶ Mulcahy, R.T.⁷

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.