Energetic analysis of the two controversial drug binding sites of the M2 proton channel in influenza A virus

Journal of Theoretical Biology

Volumn 259, Issue 1, 2009, Pages 159-164

  Du, Qi Shi ^a,b,e   Huang, Ri Bo ^a   Wang, Cheng Hua ^c   Li, Xiao Ming ^d   Chou, Kuo Chen ^e  

^a NATIONAL ENGINEERING RESEARCH CENTER FOR NON FOOD BIOREFINERY   (China)

^b GUANGXI UNIVERSITY   (China)

^c NANJING TECH UNIVERSITY   (China)

^d Nanning Fermentation and Enzyme Engineering Research   (China)

^e GORDON LIFE SCIENCE INSTITUTE   (United States)

Author keywords

Allosteric inhibition mechanism; Amantadine; M2 protein; pKa shift; Rimantadine

Indexed keywords

AMANTADINE; ANTIVIRUS AGENT; PROTEIN M2; RIMANTADINE;

BIOENERGETICS; DRUG; INFLUENZA; INHIBITION; PROTEIN;

ALLOSTERISM; ARTICLE; CHANNEL GATING; DRUG BINDING SITE; INFLUENZA VIRUS A; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PKA; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

AMANTADINE; ANTIVIRAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, VIRAL; INFLUENZA A VIRUS; ION CHANNEL GATING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; RIMANTADINE; VIRAL MATRIX PROTEINS;

INFLUENZA A VIRUS;

EID: 67349139888     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.03.003     Document Type: Article

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