Small molecule stimulation enhances bone regeneration but not titanium implant osseointegration

Bone

Volumn 57, Issue 2, 2013, Pages 405-412

  Gellynck, Kris ^a   Shah, Rishma ^a   Parkar, Mohammed ^a   Young, Anne ^a   Buxton, Paul ^a   Brett, Peter ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Bone; Hedgehog; Osseointegration; Purmorphamine; Regeneration; Titanium

Indexed keywords

BIOMATERIAL; CALCIUM PHOSPHATE; HYDROXYAPATITE; POLITEF; PURMORPHAMINE; SONIC HEDGEHOG PROTEIN; TITANIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE GROWTH; BONE REGENERATION; BONE REMODELING; CELL ASSAY; CELL DIFFERENTIATION; CHICK EMBRYO; EMBRYO; IN VITRO STUDY; IN VIVO STUDY; MATERIAL COATING; MOUSE; NEWBORN; NONHUMAN; POROSITY; SIGNAL TRANSDUCTION; TRABECULAR BONE;

BONE; HEDGEHOG; OSSEOINTEGRATION; PURMORPHAMINE; REGENERATION; TITANIUM;

ALKALINE PHOSPHATASE; ANIMALS; ANIMALS, NEWBORN; BONE MARROW; BONE REGENERATION; CALCIUM PHOSPHATES; CHICK EMBRYO; COATED MATERIALS, BIOCOMPATIBLE; FEMUR; IMPLANTS, EXPERIMENTAL; MICE; MORPHOLINES; OSSEOINTEGRATION; OSTEOGENESIS; PURINES; SPECTRUM ANALYSIS, RAMAN; TITANIUM;

EID: 84885169341     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2013.09.012     Document Type: Article

References (50)

1. Gamradt S.C., Lieberman J.R. Bone graft for revision hip arthroplasty. Clin Orthop Relat Res 2003, 417:183-194.
2. Albrektsson T., Johansson C. Osteoinduction, osteoconduction and osseointegration. Eur Spine J 2001, 10:S96-S101.
3. Aspenberg P., Goodman S., Toksviglarsen S., Ryd L., Albrektsson T. Intermittent micromotion inhibits bone ingrowth-titanium implants in rabbits. Acta Orthop Scand 1992, 63(2):141-145.
4. Costantino P.D., Hiltzik D., Govindaraj S., Moche J. Bone healing and bone substitutes. Facial Plast Surg 2002, 18(1):13-26.
5. Schindeler A., McDonald M.M., Bokko P., Little D.G. Bone remodeling during fracture repair: the cellular picture. Semin Cell Dev Biol 2008, 19(5):459-466.
6. Tuan R.S. Biology of developmental and regenerative skeletogenesis. Clin Orthop Relat Res 2004, 427:S105-S117.
7. St Jacques B., Hammerschmidt M., McMahon A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 1999, 13(16):2072-2086.
8. Colnot C., Romero D.M., Huang S., Helms J.A. Mechanisms of action of demineralized bone matrix in the repair of cortical bone defects. Clin Orthop Relat Res 2005, 435:69-78.
9. Day T.F., Yang Y.Z. Wnt and hedgehog signaling pathways in bone development. J Bone Joint Surg Am 2008, 90A:19-24.
10. Mak K.K., Chen M.H., Day T.F., Chuang P.T., Yang Y.Z. Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation. Development 2006, 133(18):3695-3707.
11. Edwards P.C., Ruggiero S., Fantasia J., Burakoff R., Moorji S.M., Paric E., et al. Sonic hedgehog gene-enhanced tissue engineering for bone regeneration. Gene Ther 2005, 12(1):75-86.
12. Kinto N., Iwamoto M., EnomotoIwamoto M., Noji S., Ohuchi H., Yoshioka H., et al. Fibroblasts expressing Sonic hedgehog induce osteoblast differentiation and ectopic bone formation. FEBS Lett 1997, 404(2-3):319-323.
13. Wu X., Ding S., Ding Q., Gray N.S., Schultz P.G. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc 2002, 124(49):14520-14521.
14. Beloti M.M., Bellesini L.S., Rosa A.L. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int 2005, 29(7):537-541.
15. Beloti M.M., Bellesini L.S., Rosa A.L. The effect of purmorphamine on osteoblast phenotype expression of human bone marrow mesenchymal cells cultured on titanium. Biomaterials 2005, 26(20):4245-4248.
16. Cousin W., Fontaine C., Dani C., Peraldi P. Hedgehog and adipogenesis: fat and fiction. Biochimie 2007, 89(12):1447-1453.
17. Fontaine C., Cousin W., Plaisant M., Dani C., Peraldi P. Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells. Stem Cells 2008, 26(4):1037-1046.
18. Sinha S., Chen J.K. Purmorphamine activates the hedgehog pathway by targeting Smoothened. Nat Chem Biol 2006, 2(1):29-30.
19. Buscher D., Grotewold L., Ruther U. The Xt(J) allele generates a Gli3 fusion transcript. Mamm Genome 1998, 9(8):676-678.
20. Hardcastle Z., Mo R., Hui C.C., Sharpe P.T. The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 1998, 125(15):2803-2811.
21. Miao D.S., Liu H.L., Plut P., Niu M.J., Huo R.J., Goltzman D., et al. Impaired endochondral bone development and osteopenia in Gli2-deficient mice. Exp Cell Res 2004, 294(1):210-222.
22. Mo R., Freer A.M., Zinyk D.L., Crackower M.A., Michaud J., Heng H.H.Q., et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 1997, 124(1):113-123.
23. Maeda Y., Nakamura E., Nguyen M.T., Suva L.J., Swain F.L., Razzaque M.S., et al. Indian hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trablecular bone. Proc Natl Acad Sci U S A 2007, 104(15):6382-6387.
24. Zhao M., Qiao M., Harris S.E., Chen D., Oyajobi B.O., Mundy G.R. The zinc finger transcription factor Gli2 mediates bone morphogenetic protein 2 expression in osteoblasts in response to hedgehog signaling. Mol Cell Biol 2006, 26(16):6197-6208.
25. Yuasa T., Kataoka H., Kinto N., Iwamoto M., Enomoto-Iwamoto M., Iemura S.I., et al. Sonic hedgehog is involved in osteoblast differentiation by cooperating with BMP-2. J Cell Physiol 2002, 193(2):225-232.
26. Spinella-Jaegle S., Rawadi G., Kawai S., Gallea S., Faucheu C., Mollat P., et al. Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci 2001, 114(11):2085-2094.
27. Nakamura T., Aikawa T., IwamotoEnomoto M., Iwamoto M., Higuchi Y., Maurizio P., et al. Induction of osteogenic differentiation by hedgehog proteins. Biochem Biophys Res Commun 1997, 237(2):465-469.
28. van der Horst G., Farih-Sips H., Lowik C.W.G.M., Karperien M. Hedgehog stimulates only osteoblastic differentiation of undifferentiated KS483 cells. Bone 2003, 33(6):899-910.
29. Peter B., Pioletti D.P., Laïb S., Bujoli B., Pilet P., Janvier P., et al. Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration. Bone 2005, 36(1):52-60.
30. Mori S., Yoshikawa H., Hashimoto J., Ueda T., Funai H., Kato M., et al. Antiangiogenic agent (TNP-470) inhibition of ectopic bone formation induced by bone morphogenetic protein-2. Bone 1998, 22(2):99-105.
31. Wozney J.M. The potential role of bone morphogenetic proteins in periodontal reconstruction. J Periodontol 1995, 66(6):506-510.
32. Wozney J.M. Engineering new bone with bone morphogenic proteins. Ann Endocrinol (Paris) 2006, 67(2):180-181.
33. Moore R., Ferretti P., Copp A., Thorogood P. Blocking endogenous FGF-2 activity prevents cranial osteogenesis. Dev Biol 2002, 243(1):99-114.
34. Buxton P.G., Bitar M., Gellynck K., Parkar M., Brown R.A., Young A.M., et al. Dense collagen matrix accelerates osteogenic differentiation and rescues the apoptotic response to MMP inhibition. Bone 2008, 43(2):377-385.
35. Peck W.A., Birge S.J., Fedak S.A. Bone cells-biochemical+biological studies after enzymatic isolation. Science 1964, 146(365):1476-1477.
36. Tenenbaum H.C., Heersche J.N.M. Dexamethasone stimulates osteogenesis in chick periosteum in vitro. Endocrinology 1985, 117(5):2211-2217.
37. Igarashi M., Kamiya N., Hasegawa M., Kasuya T., Takahashi T., Takagi M. Inductive effects of dexamethasone on the gene expression of Cbfa1, osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts. J Mol Histol 2004, 35(1):3-10.
38. Takada J., Chevalley T., Baylink D.J., Lau K.H.W. Dexamethasone enhances the osteogenic effects of fluoride in human TE85 osteosarcoma cells in vitro. Calcif Tissue Int 1996, 58(5):355-361.
39. Wozney J.M. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 1992, 32(2):160-167.
40. Yamaguchi A., Ishizuya T., Kintou N., Wada Y., Katagiri T., Wozney J.M., et al. Effects of BMP-2, BMP-4, and BMP-6 on osteoblastic differentiation of bone marrow-derived stromal cell lines, ST2 and MC3T3-G2/PA6. Biochem Biophys Res Commun 1996, 220(2):366-371.
41. Pfaffl M.W., Horgan G.W., Dempfle L. Relative expression software tool (REST (c)) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002, 30(9).
42. Liu Y.L., Layrolle P., de Bruijn J., van Blitterswijk C., de Groot K. Biomimetic coprecipitation of calcium phosphate and bovine serum albumin on titanium alloy. J Biomed Mater Res 2001, 57(3):327-335.
43. Sherf B.A., Navarro S.L., Hannah R.R., Wood K.V. Novel reporter gene technology integrating firefly and Renilla luciferase assays for internal control. Mol Biol Cell 1996, 7:925.
44. Paul W., Sharma C.P. Development of porous spherical hydroxyapatite granules: application towards protein delivery. J Mater Sci Mater Med 1999, 10(7):383-388.
45. Andacht T., Hu W., Ivarie R. Rapid and improved method for windowing eggs accessing the stage X chicken embryo. Mol Reprod Dev 2004, 69(1):31-34.
46. Piche J.E., Carnes D.L., Graves D.T. Initial characterization of cells derived from human periodontia. J Dent Res 1989, 68(5):761-767.
47. Hasselgren G. Alkaline-phosphatase in developing teeth and bone of man and macaque monkey. Acta Odontol Scand 1978, 36(3):143-148.
48. Kuroda Kensuke, Okido Masazumi Hydroxyapatite coating of titanium implants using hydroprocessing and evaluation of their osteoconductivity. Bioinorg Chem Appl 2012, 2012. [Article ID 730693, 7 pages].
49. Granéli C., Karlsson C., Lindahl A., Thomsen P. Virtual ligand-based screening reveals purmorphamine analogs with the capacity to induce the osteogenic differentiation of human mesenchymal stem cells. Cells Tissues Organs 2013, 197(2):89-102.
50. Faghihi F., Baghaban Eslaminejad M., Nekookar A., Najar M., Salekdeh G.H. The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Biomed Pharmacother 2013, 67(1):31-38.