Dense collagen matrix accelerates osteogenic differentiation and rescues the apoptotic response to MMP inhibition

Bone

Volumn 43, Issue 2, 2008, Pages 377-385

  Buxton, P G ^a   Bitar, M ^a,d   Gellynck, K ^a   Parkar, M ^a   Brown, R A ^c   Young, A M ^a   Knowles, J C ^a   Nazhat, S N ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b MCGILL UNIVERSITY   (Canada)

^c ROYAL NATIONAL ORTHOPAEDIC HOSPITAL   (United Kingdom)

^d SWISS FEDERAL LABORATORIES FOR MATERIALS SCIENCE AND TECHNOLOGY   (Switzerland)

Author keywords

Biomechanics; Dense collagen; Mineralisation; MMP; Osteoblast

Indexed keywords

APATITE; BONE MORPHOGENETIC PROTEIN 6; COLLAGEN; COLLAGEN 1A1; COLLAGEN GEL; COLLAGENASE 3; GROWTH FACTOR; ILOMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; PROTEIN; PROTEIN ALP; PROTEIN BSP; PURMORPHAMINE; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

AGONIST; ANIMAL CELL; APOPTOSIS; ARTICLE; BIOMECHANICS; BONE DEVELOPMENT; BONE GROWTH; BONE MATRIX; BONE MINERALIZATION; BONE REMODELING; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION PROFILING; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MINERALIZATION; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RIGIDITY; TISSUE ENGINEERING; UPREGULATION; YOUNG MODULUS; ZYMOGRAPHY; ANIMAL; CELL DIFFERENTIATION; CULTURE MEDIUM; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; ULTRAMICROTOMY;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; COLLAGEN; CRYOULTRAMICROTOMY; CULTURE MEDIA; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED ICR; OSTEOBLASTS; OSTEOGENESIS;

EID: 52449105081     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.03.028     Document Type: Article

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