The Novel PPAR α/γ Dual Agonist MHY 966 Modulates UVB-Induced Skin Inflammation by Inhibiting NF-κB Activity

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Park, Min Hi ^a   Park, Ji Young ^a   Lee, Hye Jin ^a   Kim, Dae Hyun ^a   Chung, Ki Wung ^a   Park, Daeui ^a   Jeong, Hyoung Oh ^a   Kim, Hye Rim ^a   Park, Chan Hum ^a   Kim, So Ra ^a   Chun, Pusoon ^b   Byun, Youngjoo ^c   Moon, Hyung Ryong ^a   Chung, Hae Young ^a  

^a Pusan National University   (South Korea)

^b Inje University   (South Korea)

^c Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMO 4 (5 CHLOROBENZO[D]THIAZOL 2 YL)PHENOL; CYCLOOXYGENASE 2; FENOFIBRATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MHY 966; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA GAMMA DUAL AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLLAGEN DEGRADATION; CONTROLLED STUDY; DERMATITIS; DOWN REGULATION; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; DRUG PROTEIN BINDING; ENZYME ACTIVATION; HISTOPATHOLOGY; HYDROPHOBICITY; IN VITRO STUDY; LIPID PEROXIDATION; MALE; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RADIATION EXPOSURE; RAT; REPORTER GENE; SKIN; TRANSCRIPTION INITIATION; TREATMENT INDICATION; ULTRAVIOLET B RADIATION; WRINKLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOTHIAZOLES; COLLAGEN; GENE EXPRESSION REGULATION; INFLAMMATION; LIPID PEROXIDATION; MALE; MICE; MOLECULAR DOCKING SIMULATION; NF-KAPPA B; PEROXYNITROUS ACID; PHENOLS; PPAR ALPHA; PPAR GAMMA; PROTEIN CONFORMATION; PROTEOLYSIS; SKIN; TRANSCRIPTION, GENETIC; ULTRAVIOLET RAYS;

EID: 84885161608     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076820     Document Type: Article

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