Deletion of the Sequence Encoding the Tail Domain of the Bone Morphogenetic Protein type 2 Receptor Reveals a Bone Morphogenetic Protein 7-Specific Gain of Function

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Leyton, Patricio A ^a   Beppu, Hideyuki ^a,b   Pappas, Alexandra ^a   Martyn, Trejeeve M ^a   Derwall, Matthias ^a,c   Baron, David M ^a,d   Galdos, Rita ^a   Bloch, Donald B ^a   Bloch, Kenneth D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF TOYAMA   (Japan)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 2; OSTEOGENIC PROTEIN 1; SMALL INTERFERING RNA;

ALK2 GENE; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTERY MUSCLE; ARTICLE; CONTROLLED STUDY; DEATH; EMBRYO; EMBRYO DEVELOPMENT; GAIN OF FUNCTION MUTATION; GASTRULATION; GENE; GENE DELETION; GENE SEQUENCE; HETEROZYGOSITY; HOMOZYGOSITY; LUNG ARTERY; MOUSE; NONHUMAN; NONSENSE MEDIATED MRNA DECAY; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ACTIVIN RECEPTORS, TYPE I; ACTIVIN RECEPTORS, TYPE II; ANIMALS; BINDING SITES; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 7; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; CELLS, CULTURED; GENE EXPRESSION; GENOTYPE; HYPERTENSION, PULMONARY; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PULMONARY ARTERY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE DELETION; SMAD6 PROTEIN;

EID: 84885158328     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076947     Document Type: Article

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