Craniofacial defects in mice lacking BMP type I receptor Alk2 in neural crest cells

Mechanisms of Development

Volumn 121, Issue 2, 2004, Pages 173-182

  Dudas, Marek ^a   Sridurongrit, Somyoth ^a   Nagy, Andre ^a   Okazaki, Kenji ^b   Kaartinen, Vesa ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b BIOMOL ENG RESEARCH INSTITUTE   (Japan)

Author keywords

Alk2; Bone morphogenetic protein; Cleft palate; Cranial bones; Craniofacial neural crest; Mandible; Meckel's cartilage; Mental symphysis; Temporomandibular joint

Indexed keywords

BONE MORPHOGENETIC PROTEIN;

ALLELE; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CLEFT PALATE; CRANIOFACIAL DEVELOPMENT; DEVELOPMENT; GENE LOCUS; MANDIBLE; MOLECULE; MORPHOGENESIS; MOUSE; NEURAL CREST; NEURAL CREST CELL; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL PROCESSING;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; ANIMALS, NEWBORN; CLEFT PALATE; CRANIOFACIAL ABNORMALITIES; GENE TARGETING; MANDIBLE; MICE; MICE, KNOCKOUT; NEURAL CREST; PROTEINS;

EID: 1642392579     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mod.2003.12.003     Document Type: Article

References (33)

1. Bronner-Fraser M. Origins and developmental potential of the neural crest. Exp. Cell Res. 218:1995;405-417.
2. Chai Y., Jiang X., Ito Y., Bringas P. Jr., Han J., Rowitch D.H., et al. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development. 127:2000;1671-1679.
3. Danielian P.S., Muccino D., Rowitch D.H., Michael S.K., McMahon A.P. Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Curr. Biol. 8:1998;1323-1326.
4. Derynck R., Feng X.H. TGF-beta receptor signaling. Biochim. Biophys. Acta. 1333:1997;F105-F150.
5. Derynck R., Zhang Y., Feng X.-F. Smads: transcriptional activators of TGF-β responses. Cell. 95:1998;737-740.
6. Dickinson M.E., Selleck M.A., McMahon A.P., Bronner-Fraser M. Dorsalization of the neural tube by the non-neural ectoderm. Development. 121:1995;2099-2106.
7. ten Dijke P., Goumans M.-J., Itoh F., Itoh S. Regulation of cell proliferation by Smad proteins. J. Cell. Physiol. 191:2002;1-16.
8. Dudas M., Nagy A., Laping N.J., Moustakas A., Kaartinen V. Tgf-β3-induced palatal fusion is mediated by Alk-5/Smad pathway. Dev. Biol. 2004;. 266, 96-108.
9. Feng X.H., Derynck R. A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity. Eur. Mol. Biol. Organ. J. 16:1997;3912-3923.
10. Graham A., Francis-West P., Brickell P., Lumsden A. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest. Nature. 372:1994;684-686.
11. Gu Z., Reynolds E.M., Song J., Lei H., Feijen A., Yu L., et al. The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo. Development. 126:1999;2551-2561.
12. Heldin C.-H., Miyazono K., Dijke P.T. Tgf-β signaling from cell membrane to nucleus through Smad proteins. Nature. 390:1997;465-471.
13. Hogan B., Beddington R., Costantini F., Lacy E. Hogan B., Beddington R., Costantini F., Lacy E. Manipulating the mouse embryo. A laboratory manual. 1994;Cold Spring Harbor Laboratory Press, New York.
14. Ito Y., Bringas P. Jr., Mogharei A., Zhao J., Deng C., Chai Y. Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development. Dev. Dyn. 224:2002;69-78.
15. Jiang X., Rowitch D.H., Soriano P., McMahon A.P., Sucov H.M. Fate of the mammalian cardiac neural crest. Development. 127:2000;1607-1616.
16. Kaartinen V., Nagy A. Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo. Genesis. 31:2001;126-129.
17. Kaartinen V., Voncken J.W., Shuler C., Warburton D., Bu D., Heisterkamp N., Groffen J. Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction. Nat. Genet. 11:1995;415-421.
18. Kanzler B., Foreman R.K., Labosky P.A., Mallo M. BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest. Development. 127:2000;1095-1104.
19. LaBonne C., Bronner-Fraser M. Molecular mechanisms of neural crest formation. Annu. Rev. Cell Dev. Biol. 15:1999;81-112.
20. Liem K.F. Jr, Tremml G., Roelink H., Jessell T.M. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell. 82:1995;969-979.
21. Marazzi G., Wang Y., Sassoon D. Msx2 is a transcriptional regulator in the BMP4-mediated programmed cell death pathway. Dev. Biol. 186:1997;127-138.
22. Massague J. TGF-beta signal transduction. Annu. Rev. Biochem. 67:1998;753-791.
23. Mina M., Wang Y.H., Ivanisevic A.M., Upholt W.B., Rodgers B. Region- and stage-specific effects of FGFs and BMPs in chick mandibular morphogenesis. Dev. Dyn. 223:2002;333-352.
24. Mishina Y., Suzuki A., Ueno N., Behringer R.R. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev. 9:1995;3027-3037.
25. Mishina Y., Crombie R., Bradley A., Behringer R.R. Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis. Dev. Biol. 213:1999;314-326.
26. Moustakas A. Smad signaling network. J. Cell Sci. 115:2002;3355-3356.
27. Papaioannou V., Johnson R. Production of chimeras and genetically defined offspring. Joyner A.D. Gene Targeting: A Practical Approach. 1993;104-146 IRL Press, Oxford.
28. Pietri T., Eder O., Blanche M., Thiery J.P., Dufour S. The human plasminogen activator-Cre mouse: a new tool for targeting specifically neural crest cells and their derivatives in vivo. Dev. Biol. 259:2003;176-187.
29. Slavkin H., Nuckolls G., Shum L. Craniofacial Development and Patterning. Tuan R.S., Lo C.W. Methods in Molecular Biology; Developmental Biology Protocolls. 2000;45-54 Humana Press, Totowa.
30. Solloway M.J., Robertson E.J. Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development. 126:1999;1753-1768.
31. Stottmann R.W., Anderson R.M., Klingensmith J. The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. Dev. Biol. 240:2001;457-473.
32. Tan S.S., Morriss-Kay G.M. Analysis of cranial neural crest cell migration and early fates in postimplantation rat chimaeras. J. Embryol. Exp. Morphol. 98:1986;21-58.
33. Yoshikawa S.I., Aota S., Shirayoshi Y., Okazaki K. The ActR-I activin receptor protein is expressed in notochord, lens placode and pituitary primordium cells in the mouse embryo. Mech. Dev. 91:2000;439-444.