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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 21, 2013, Pages 5870-5873

Discovery and structure-activity relationships of 6-(benzoylamino) benzoxaboroles as orally active anti-inflammatory agents

(15) Akama, Tsutomu a Dong, Chen a Virtucio, Charlotte a Freund, Yvonne R a Chen, Daitao b Orr, Matthew D b Jacobs, Robert T a,b Zhang, Yong Kang a Hernandez, Vincent a Liu, Yang a Wu, Anne a Bu, Wei a Liu, Liang a Jarnagin, Kurt a Plattner, Jacob J a

a PFIZER INC (United States)

b Scynexis Inc (United States)

Author keywords

Anti inflammatory; Benzoxaborole; Collagen induced arthritis; Cytokine; Interleukin 1beta; Interleukin 6; Pharmacokinetics; Structure activity relationships; Tumor necrosis factor alpha

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (BENZOYLAMINO)BENZOXABOROLE DERIVATIVE; AN 4161; ANTIINFLAMMATORY AGENT; CLOBETASOL; DEXAMETHASONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PREDNISOLONE; SULFONAMIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE COURSE; DRUG CLEARANCE; DRUG SYNTHESIS; HALF LIFE TIME; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION; TREATMENT DURATION;

ANTI-INFLAMMATORY; BENZOXABOROLE; COLLAGEN-INDUCED ARTHRITIS; CYTOKINE; INTERLEUKIN-1BETA; INTERLEUKIN-6; PHARMACOKINETICS; STRUCTURE-ACTIVITY RELATIONSHIPS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, EXPERIMENTAL; BENZENE DERIVATIVES; BORON COMPOUNDS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84885154828 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.08.096 Document Type: Article

Times cited : (20)

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