Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 3, 2012, Pages 1299-1307

  Zhang, Yong Kang ^a   Plattner, Jacob J ^a   Freund, Yvonne R ^a   Easom, Eric E ^a   Zhou, Yasheen ^a   Ye, Long ^b   Zhou, Huchen ^b   Waterson, David ^c   Gamo, Francisco Javier ^d   Sanz, Laura M ^d   Ge, Min ^e   Li, Zhiya ^e   Li, Lingchao ^e   Wang, Hailong ^e   Cui, Han ^e  

^a PFIZER INC   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c International Center Cointrin   (Switzerland)

^d GLAXOSMITHKLINE   (Spain)

^e Science and Technology Building 24B   (China)

Author keywords

Antimalarial agent; Benzoxaborole; Boron containing compound; Plasmodium falciparum; Structure activity relationship

Indexed keywords

ANTIMALARIAL AGENT; BORON DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; IC 50; MALARIA FALCIPARUM; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; WITTIG REACTION;

ANTIMALARIALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BORON COMPOUNDS; CELL SURVIVAL; FLUORINE; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; JURKAT CELLS; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 84862810973     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.096     Document Type: Article

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