Discovery of novel benzoxaborole-based potent antitrypanosomal agents

ACS Medicinal Chemistry Letters

Volumn 1, Issue 4, 2010, Pages 165-169

  Ding, Dazhong ^a   Zhao, Yaxue ^a   Meng, Qingqing ^a   Xie, Dongsheng ^a   Nare, Bakela ^b   Chen, Daitao ^b   Bacchi, Cyrus J ^c   Yarlett, Nigel ^c   Zhang, Yong Kang ^d   Hernandez, Vincent ^d   Xia, Yi ^d   Freund, Yvonne ^d   Abdulla, Maha ^e   Ang, Kean Hooi ^e   Ratnam, Joseline ^e   McKerrow, James H ^e   Jacobs, Robert T ^b   Zhou, Huchen ^a   Plattner, Jacob J ^d  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SCYNEXIS Inc   (United States)

^c PACE UNIVERSITY   (United States)

^d PFIZER INC   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

African trypanosomiasis; benzoxaborole; Tryapnosoma brucei

Indexed keywords

4 CHLOROPHENYLSULFOXIDE; ANTITRYPANOSOMAL AGENT; BENZOXABOROLE; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOTOXICITY; DRUG EFFICACY; DRUG SYNTHESIS; FEMALE; GROWTH INHIBITION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI; TRYPANOSOMIASIS;

MURINAE;

EID: 77955903018     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100013s     Document Type: Article

References (12)

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