Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 6, 2013, Pages 1680-1683

  Akama, Tsutomu ^a   Virtucio, Charlotte ^a   Dong, Chen ^a   Kimura, Richard ^a   Zhang, Yong Kang ^a   Nieman, James A ^b   Sharma, Rashmi ^b   Lu, Xiaosong ^b   Sales, Marcelo ^b   Singh, Rajeshwar ^b   Wu, Anne ^a   Fan, Xiao Qing ^a   Liu, Liang ^a   Plattner, Jacob J ^a   Jarnagin, Kurt ^a   Freund, Yvonne R ^a  

^a PFIZER INC   (United States)

^b NAEJA Pharmaceuticals Inc   (Canada)

Author keywords

Anti inflammatory; Benzoxaborole; Cytokine; Interleukin 1beta; Interleukin 6; Pharmacokinetics; Structure activity relationships; Tumor necrosis factor alpha

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (AMINOMETHYLPHENOXY) BENZOXABOROLE DERIVATIVE; AN 3485; ANTIINFLAMMATORY AGENT; CLOBETASOL; DEXAMETHASONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; ORGANOBORON DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; STRUCTURE ACTIVITY RELATION; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BENZOXAZOLES; BICYCLO COMPOUNDS, HETEROCYCLIC; BORON COMPOUNDS; HALF-LIFE; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; KINETICS; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MICE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84874666253     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.072     Document Type: Article

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