Inhibition of sPLA2-IIA Prevents LPS-Induced Neuroinflammation by Suppressing ERK1/2-cPLA2α Pathway in Mice Cerebral Cortex

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Xiang, Yanxiao ^a   Chen, Lin ^a   Liu, Huiqing ^a   Liu, Xiaoqian ^a   Wei, Xinbing ^a   Sun, Baozhu ^b   Wang, Tian ^c   Zhang, Xiumei ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANDONG UNIVERSITY   (China)

^c YANTAI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN ENZYME; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; CYTOSOLIC PHOSPHOLIPASE A2 ALPHA; ENZYME INHIBITOR; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; SECRETORY PHOSPHOLIPASE A2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; CONTROLLED STUDY; DISEASE CONTROL; ENCEPHALITIS; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PROSTAGLANDIN RELEASE; PROTEIN TARGETING; RAT;

ANIMALS; ASTROCYTES; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME INHIBITORS; GROUP II PHOSPHOLIPASES A2; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; PHOSPHOLIPASES A2, CYTOSOLIC; RATS; RATS, WISTAR;

EID: 84885153882     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077909     Document Type: Article

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