Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA 2, COX-1 and COX-2 selective inhibitors, and an LTC 4 receptor antagonist

British Journal of Pharmacology

Volumn 140, Issue 1, 2003, Pages 71-80

  Arumugam, Thiruma V ^a   Arnold, Naomi ^a   Proctor, Lavinia M ^a   Newman, Michelle ^a   Reid, Robert C ^a   Hansford, Karl A ^a   Fairlie, David P ^a   Shiels, Ian A ^a   Taylor, Stephen M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

COX 1; COX 2; Gut ischaemia reperfusion; Histopathology; Inflammation; LTC 4; Neutropenia; Pharmacokinetics; sPLA 2

Indexed keywords

5 (4 BENZYLOXYPHENYL) 4 (7 PHENYLHEPTANOYLAMINO)PENTANOIC ACID; ASPARTATE AMINOTRANSFERASE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; FLUNIXIN; LEUKOTRIENE C4 RECEPTOR ANTAGONIST; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG; ZAFIRLUKAST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SELECTIVITY; EDEMA; ENZYME BLOOD LEVEL; ENZYME INHIBITION; GASTROINTESTINAL HEMORRHAGE; HISTOPATHOLOGY; HYPOTENSION; INTESTINE ISCHEMIA; INTESTINE PERFUSION; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RAT; REPERFUSION INJURY; SMALL INTESTINE MUCOSA;

ANIMALS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; FEMALE; INTESTINE, SMALL; ISOENZYMES; LEUKOTRIENE ANTAGONISTS; MEMBRANE PROTEINS; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; RECEPTORS, LEUKOTRIENE; REPERFUSION INJURY;

EID: 0141730388     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705402     Document Type: Article

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