The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist gsk1521498 in healthy subjects

Journal of Clinical Pharmacology

Volumn 53, Issue 10, 2013, Pages 1078-1090

  Ziauddeen, Hisham ^a,b,g   Nathan, Pradeep J ^a,b,c   Dodds, Chris ^a   Maltby, Kay ^a   Miller, Sam R ^a   Waterworth, Dawn ^d   Song, Kijoung ^d   Warren, Liling ^d   Hosking, Louise ^a   Zucchetto, Mauro ^a   Bush, Mark ^e   Johnson, Lakshmi Vasist ^e   Sarai, Bhopinder ^a   Mogg, Karin ^f   Bradley, Brendan P ^f   Richards, Duncan B ^h   Fletcher, Paul C ^b,g   Bullmore, Edward T ^a,b,g,h  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MONASH UNIVERSITY   (Australia)

^d GLAXOSMITHKLINE   (United States)

^e Kinetigen   (United States)

^f UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^g CAMBRIDGESHIRE AND PETERBOROUGH NHS FOUNDATION TRUST   (United Kingdom)

^h ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Addiction; Alcohol; Mu opioidreceptor; Oprm1; Pharmacodynamics; Pharmacogenetics; Pharmacokinetics; Safety

Indexed keywords

ALCOHOL; GSK 1521498; MU OPIATE RECEPTOR ANTAGONIST; PLACEBO; UNCLASSIFIED DRUG;

ABDOMINAL DISTENSION; ADULT; ALERTNESS; AREA UNDER THE CURVE; ARTICLE; ATTENTION DISTURBANCE; CLINICAL ARTICLE; CONTROLLED STUDY; COORDINATION DISORDER; CROSSOVER PROCEDURE; DECREASED APPETITE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG ALCOHOL INTERACTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STRUCTURE; DRUG TOLERABILITY; DRUNK SENSATION; EUPHORIA; FATIGUE; FEMALE; GAIT DISORDER; GENETIC POLYMORPHISM; HEADACHE; HUMAN; MALE; MAXIMUM PLASMA CONCENTRATION; MOOD; NAUSEA; NAUSEA AND VOMITING; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; RISK ASSESSMENT; SIDE EFFECT; SKIN IRRITATION; SOMNOLENCE; TIME TO MAXIMUM PLASMA CONCENTRATION; VOMITING;

ADDICTION; ALCOHOL; MU-OPIOID RECEPTOR; OPRM1; PHARMACODYNAMICS; PHARMACOGENETICS; PHARMACOKINETICS; SAFETY;

ADULT; AFFECT; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG INTERACTIONS; ETHANOL; HUMANS; INDANS; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, OPIOID, MU; TRIAZOLES; YOUNG ADULT;

EID: 84885114545     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1002/jcph.110     Document Type: Article

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