Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers

Clinical Therapeutics

Volumn 28, Issue 9, 2006, Pages 1308-1317

  Shah, Jaymin ^a,d   Wesnes, Keith A ^b,c,d   Kovelesky, Rosemary A ^a,d   Henney III, Herbert R ^c,d  

^a ELAN PHARMACEUTICALS   (United States)

^b Harvard Medical School   (United Kingdom)

^c NOVARTIS PHARMA AG   (Switzerland)

^d Aorda Therapeutics Inc   (United States)

Author keywords

bioavailability; formulation; pharmacodynamics; pharmacokinetics; tizanidine

Indexed keywords

TIZANIDINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHENIA; BIOEQUIVALENCE; BLOOD SAMPLING; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DIZZINESS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CAPSULE; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; FEMALE; FOOD DRUG INTERACTION; FUNCTION TEST; HUMAN; HUMAN EXPERIMENT; MALE; ORTHOSTATIC HYPOTENSION; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; SOMNOLENCE; TABLET FORMULATION; VALIDATION STUDY; VOLUNTEER; XEROSTOMIA;

ADOLESCENT; ADULT; CAPSULES; CLONIDINE; COGNITION; CROSS-OVER STUDIES; DISORDERS OF EXCESSIVE SOMNOLENCE; FEMALE; FOLLOW-UP STUDIES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; REFERENCE VALUES; TABLETS;

EID: 33750044052     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2006.09.014     Document Type: Article

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