Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum

European Journal of Biochemistry

Volumn 268, Issue 11, 2001, Pages 3354-3359

  Abe, Ikuro ^a   Takahashi, Yusuke ^a   Morita, Hiroyuki ^a   Noguchi, Hiroshi ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Benzalacetone synthase; Chalcone synthase; Phenylbutanoids; Polyketide synthase; Rheum palmatum

Indexed keywords

2 BUTANONE; 4 COUMAROYL COENZYME A; ACETYL COENZYME A; AMINO ACID; BENZALACETONE SYNTHASE; CHALCONE SYNTHASE; COENZYME A; COMPLEMENTARY DNA; CYSTEINE; HEXANOYL COENZYME A; HISTIDINE; ISOBUTYRYL COENZYME A; ISOVALERYL COENZYME A; MALONYL COENZYME A; PHENYL GROUP; PHENYLBUTANONE; POLYKETIDE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; ENZYME PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR CLONING; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RHUBARB; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BUTANONES; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ESCHERICHIA COLI; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PHYLOGENY; PLANT PROTEINS; PLANTS, MEDICINAL; RHEUM;

EMBRYOPHYTA; ESCHERICHIA COLI; RHEUM PALMATUM; RHEUM X CULTORUM; ZINGIBER OFFICINALE;

EID: 0034845768     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02255.x     Document Type: Article

References (30)

1. The chalcone/stilbene synthase-type family of condensing enzymes
2. A family of plant-specific polyketide synthases: Facts and predictions
3. Molecular analysis of resveratrol synthase. cDNA, genomic clones and relationship with chalcone synthase
4. New pathway to polyketides in plants
5. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis
6. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase
7. Studies on rhubarb (Rhei rhizoma). II. Anthraquinone glycosides
8. Studies on rhubarb (Rhei rhizoma). XIV. Stilbene glucosides
9. Studies on Rhubarb (Rhei rhizoma). IV. Naphtalene glycosides
10. Tannins and related compounds. I. Rhubarb (1)
11. Tannins and related compounds. X. Rhubarb (2)
12. Substrate specificity of chalcone synthase: Enzymatic formation of unnatural polyketides from synthetic cinnamoyl-CoA analogs
13. Enzymatic formation of unnatural aromatic polyketides by chalcone synthase
14. Chalcone synthase from Scutellaria baicalensis
15. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
16. Confidence limits on phylogenies: An approach using bootstrap
17. Jacknife, bootstrap and other sampling plans in regression analysis
18. PHYLIP - Phylogeny inference package (version 3.2)
19. Isolation and characterization of the β-ketoacyl-acyl carrier protein synthase III gene (fabH) from Escherichia coli K-12
20. Evidence that stilbene synthases have developed from chalcone synthases several times in the course of evolution
21. Mechanism of chalcone synthase: pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase
22. Evidence for catalytic cysteine-histidine dyad in chalcone synthase
23. Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones
24. Cloning and analysis of valerophenone synthase gene expressed specifically in lupulin gland of hop (Humulus lupulus L.)
25. p-Coumaroyltriacetic acid synthase, a new homologue of chalcone synthase, from Hydrangea macrophylla var. thunbergii
26. Specificities of functionally expressed chalcone and acridone synthases from Ruta graveolens
27. Evolution of the chalcone synthase gene family in the genus Ipomoea
28. Biosynthesis of p-hydroxyphenylbutan-2-one in raspberry fruits and tissue cultures
29. Aromatic polyketide synthases. Purification, characterization, and antibody development to benzalacetone synthase from raspberry fruits
30. Studies in the biosynthesis of [6]-gingerol, pungent principle of ginger (Zingiber officinale)