Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells

International Journal of Oncology

Volumn 43, Issue 5, 2013, Pages 1413-1419

  Kanno, Syu Ichi ^a   Yomogida, Shin ^a   Tomizawa, Ayako ^a   Yamazaki, Hiroyuki ^a   Ukai, Kazuyo ^a   Mangindaan, Remy E P ^b   Namikoshi, Michio ^a   Ishikawa, Masaaki ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b SAM RATULANGI UNIVERSITY   (Indonesia)

Author keywords

Autophagy; C Jun N terminal kinase; Cytotoxicity; Mitochondrial damage; Papuamine

Indexed keywords

3 METHYLADENINE; CYTOCHROME C; NATURAL PRODUCT; PAPUAMINE; PROTEIN BAX; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST CANCER; CANCER CELL CULTURE; CELL STRAIN MCF 7; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG CYTOTOXICITY; DRUG EXPOSURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN SECRETION; REDUCTION;

ALKALOIDS; APOPTOSIS; AUTOPHAGY; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; CYTOCHROMES C; FEMALE; HUMANS; MAP KINASE KINASE 4; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 84885075531     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2093     Document Type: Article

References (41)

1. Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell 132: 27-42, 2008.
2. Yang Z and Klionsky DJ: Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131, 2010.
3. Deretic V, Delgado M, Vergne I, et al: Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy. Curr Top Microbiol Immunol 335: 169-188, 2009.
4. Maiuri MC, Zalckvar E, Kimchi A and Kroemer G: Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 8: 741-752, 2007.
5. Livesey KM, Tang D, Zeh HJ and Lotze MT: Autophagy inhibition in combination cancer treatment. Curr Opin Investig Drugs 10: 1269-1279, 2009.
6. Taguchi-Atarashi N, Hamasaki M, Matsunaga K, et al: Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Traffic 11: 468-478, 2010.
7. Adams JM and Cory S: The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26: 1324-1337, 2007.
8. Green DR and Kroemer G: Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest 115: 2610-2617, 2005.
9. Danial NN and Korsmeyer SJ: Cell death: critical control points. Cell 116: 205-219, 2004.
10. Wang X: The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933, 2001.
11. Kim KW, Mutter RW, Cao C, et al: Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling. J Biol Chem 281: 36883-36890, 2006.
12. Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B and Codogno P: Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem 284: 2719-2728, 2009.
13. Ham YM, Chun KH, Choi JS, Kim DH and Lee SK: SEK1-dependent JNK1 activation prolongs cell survival during G-Rh2-induced apoptosis. Biochem Biophys Res Commun 304: 358-364, 2003.
14. Zhou F, Yang Y and Xing D: Bcl-2 and Bcl-xL play important roles in the crosstalk between autophagy and apoptosis. FEBS J 278: 403-413, 2011.
15. Lemasters JJ, Qian T, He L, et al: Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy. Antioxid Redox Signal 4: 769-781, 2002.
16. Baker BJ, Scheuer PJ and Shoolery JN: Papuamine, an antifungal pentacyclic alkaloid from a marine sponge, Haliclona sp. J Am Chem Soc 110: 965-966, 1996.
17. Yamazaki H, Wewengkang DS, Kanno SI, et al: Papuamine and haliclonadiamine, obtained from an Indonesian sponge Haliclona sp., inhibited cell proliferation of human cancer cell lines. Nat Prod Res 27: 1012-1015, 2013.
18. Kanno S, Shouji A, Asou K and Ishikawa M: Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. J Pharmacol Sci 92: 166-170, 2003.
19. Shimizu S, Narita M and Tsujimoto Y: Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483-487, 1999.
20. Mizushima N, Yamamoto A, Matsui M, Yoshimori T and Ohsumi Y: In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111, 2004.
21. Asanuma K, Tanida I, Shirato I, et al: MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J 17: 1165-1167, 2003.
22. Seglen PO and Gordon PB: 3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytes. Proc Natl Acad Sci USA 79: 1889-1892, 1982.
23. Jia L, Dourmashkin RR, Allen PD, Gray AB, Newland AC and Kelsey SM: Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol 98: 673-685, 1997.
24. Herman-Antosiewicz A, Johnson DE and Singh SV: Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. Cancer Res 66: 5828-5835, 2006.
25. Xue L, Fletcher GC and Tolkovsky AM: Autophagy is activated by apoptotic signalling in sympathetic neurons: an alternative mechanism of death execution. Mol Cell Neurosci 14: 180-198, 1999.
26. Shimizu S, Kanaseki T, Mizushima N, et al: Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6: 1221-1228, 2004.
27. Lockshin RA and Zakeri Z: Apoptosis, autophagy, and more. Int J Biochem Cell Biol 36: 2405-2419, 2004.
28. Debnath J: The multifaceted roles of autophagy in tumors - implications for breast cancer. J Mammary Gland Biol Neoplasia 16: 173-187, 2011.
29. Bursch W, Ellinger A, Kienzl H, et al: Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy. Carcinogenesis 17: 1595-1607, 1996.
30. Kim R, Emi M and Tanabe K: Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol 57: 545-553, 2006.
31. Xue LY, Chiu SM, Azizuddin K, Joseph S and Oleinick NL: Protection by Bcl-2 against apoptotic but not autophagic cell death after photodynamic therapy. Autophagy 4: 125-127, 2008.
32. Pattingre S and Levine B: Bcl-2 inhibition of autophagy: a new route to cancer? Cancer Res 66: 2885-2888, 2006.
33. Reed JC: Bcl-2 and the regulation of programmed cell death. J Cell Biol 124: 1-6, 1994.
34. Jia L, Patwari Y, Srinivasula SM, et al: Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis. Oncogene 20: 4817-4826, 2001.
35. Motyl T, Gajkowska B, Zarzynska J, Gajewska M and Lamparska-Przybysz M: Apoptosis and autophagy in mammary gland remodeling and breast cancer chemotherapy. J Physiol Pharmacol 57 (Suppl 7): 17-32, 2006.
36. Hoye AT, Davoren JE, Wipf P, Fink MP and Kagan VE: Targeting mitochondria. Acc Chem Res 41: 87-97, 2008.
37. Mijaljica D, Prescott M and Devenish RJ: Different fates of mitochondria: alternative ways for degradation? Autophagy 3: 4-9, 2007.
38. Lei K and Davis RJ: JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc Natl Acad Sci USA 100: 2432-2437, 2003.
39. Sheng Y, Sun B, Guo WT, et al: 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Biochem Biophys Res Commun 432: 5-9, 2013.
40. Wu YT, Tan HL, Shui G, et al: Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J Biol Chem 285: 10850-10861, 2010.
41. Heckmann BL, Yang X, Zhang X and Liu J: The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes. Br J Pharmacol 168: 163-171, 2013.