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Volumn 123, Issue 10, 2013, Pages 4390-4404

Epithelial stem cell mutations that promote Squamous cell carcinoma metastasis

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; ASPARTIC ACID; CYTOKERATIN 15; DOCETAXEL; GLYCINE; K RAS PROTEIN; MICRORNA 9; MIFEPRISTONE; SMAD4 PROTEIN; UVOMORULIN; VERAPAMIL; KRAS PROTEIN, HUMAN; MICRORNA; MIRN92 MICRORNA, HUMAN; ONCOPROTEIN; RAS PROTEIN; SMAD4 PROTEIN, HUMAN;

EID: 84885064479     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI65856     Document Type: Article
Times cited : (80)

References (66)
  • 1
    • 34547128098 scopus 로고    scopus 로고
    • Metastatic cutaneous squamous cell carcinoma: An update
    • Weinberg AS, Ogle CA, Shim EK. Metastatic cutaneous squamous cell carcinoma: an update. Dermatol Surg. 2007;33(8):885-899.
    • (2007) Dermatol Surg , vol.33 , Issue.8 , pp. 885-899
    • Weinberg, A.S.1    Ogle, C.A.2    Shim, E.K.3
  • 2
    • 0021805298 scopus 로고
    • Prognostic and therapeutic use of microstaging of cutaneous squamous cell carcinoma of the trunk and extremities
    • Friedman HI, Cooper PH, Wanebo HJ. Prognostic and therapeutic use of microstaging of cutaneous squamous cell carcinoma of the trunk and extremities. Cancer. 1985;56(5):1099-1105.
    • (1985) Cancer , vol.56 , Issue.5 , pp. 1099-1105
    • Friedman, H.I.1    Cooper, P.H.2    Wanebo, H.J.3
  • 3
    • 84856557238 scopus 로고    scopus 로고
    • From keratinocyte to cancer: The pathogenesis and modeling of cutaneous squamous cell carcinoma
    • Ratushny V, Gober MD, Hick R, Ridky TW, Seykora JT. From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest. 2012;122(2):464-472.
    • (2012) J Clin Invest , vol.122 , Issue.2 , pp. 464-472
    • Ratushny, V.1    Gober, M.D.2    Hick, R.3    Ridky, T.W.4    Seykora, J.T.5
  • 4
    • 70449338760 scopus 로고    scopus 로고
    • Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
    • Bornstein S, et al. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest. 2009;119(11):3408-3419.
    • (2009) J Clin Invest , vol.119 , Issue.11 , pp. 3408-3419
    • Bornstein, S.1
  • 5
    • 30544444184 scopus 로고    scopus 로고
    • Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin
    • Qiao W, Li AG, Owens P, Xu X, Wang XJ, Deng CX. Hair follicle defects and squamous cell carcinoma formation in Smad4 conditional knockout mouse skin. Oncogene. 2006;25(2):207-217.
    • (2006) Oncogene , vol.25 , Issue.2 , pp. 207-217
    • Qiao, W.1    Li, A.G.2    Owens, P.3    Xu, X.4    Wang, X.J.5    Deng, C.X.6
  • 6
    • 33746919897 scopus 로고    scopus 로고
    • Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse
    • Teng Y, et al. Synergistic function of Smad4 and PTEN in suppressing forestomach squamous cell carcinoma in the mouse. Cancer Res. 2006;66(14):6972-6981.
    • (2006) Cancer Res , vol.66 , Issue.14 , pp. 6972-6981
    • Teng, Y.1
  • 7
    • 84856078085 scopus 로고    scopus 로고
    • A family business: Stem cell progeny join the niche to regulate homeostasis
    • Hsu YC, Fuchs E. A family business: stem cell progeny join the niche to regulate homeostasis. Nat Rev Mol Cell Biol. 2012;13(2):103-114.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , Issue.2 , pp. 103-114
    • Hsu, Y.C.1    Fuchs, E.2
  • 8
    • 84857570226 scopus 로고    scopus 로고
    • Epithelial stem cells, wound healing and cancer
    • Arwert EN, Hoste E, Watt FM. Epithelial stem cells, wound healing and cancer. Nat Rev Cancer. 2012;12(3):170-180.
    • (2012) Nat Rev Cancer , vol.12 , Issue.3 , pp. 170-180
    • Arwert, E.N.1    Hoste, E.2    Watt, F.M.3
  • 10
    • 84881591565 scopus 로고    scopus 로고
    • Follicular cutaneous squamous cell carcinoma: An underrecognized neoplasm arising from hair appendage structures
    • Shendrik I, Crowson AN, Magro CM. Follicular cutaneous squamous cell carcinoma: an underrecognized neoplasm arising from hair appendage structures. Br J Dermatol. 2013;169(2):384-388.
    • (2013) Br J Dermatol , vol.169 , Issue.2 , pp. 384-388
    • Shendrik, I.1    Crowson, A.N.2    Magro, C.M.3
  • 11
    • 0242658564 scopus 로고    scopus 로고
    • Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge
    • Liu Y, Lyle S, Yang Z, Cotsarelis G. Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J Invest Dermatol. 2003;121(5):963-968.
    • (2003) J Invest Dermatol , vol.121 , Issue.5 , pp. 963-968
    • Liu, Y.1    Lyle, S.2    Yang, Z.3    Cotsarelis, G.4
  • 12
    • 0035893252 scopus 로고    scopus 로고
    • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    • Jackson EL, et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 2001;15(24):3243- 3248.
    • (2001) Genes Dev , vol.15 , Issue.24 , pp. 3243-3248
    • Jackson, E.L.1
  • 13
    • 84884817124 scopus 로고    scopus 로고
    • A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse [published online ahead of print March 16
    • doi:10. 1002/mc. 21896
    • Li S, et al. A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse [published online ahead of print March 16, 2012]. Mol Carcinog. doi:10. 1002/mc. 21896.
    • (2012) Mol Carcinog
    • Li, S.1
  • 14
    • 79956317899 scopus 로고    scopus 로고
    • Identifying the cellular origin of squamous skin tumors
    • Lapouge G, et al. Identifying the cellular origin of squamous skin tumors. Proc Natl Acad Sci U S A. 2011;108(18):7431-7436.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.18 , pp. 7431-7436
    • Lapouge, G.1
  • 15
    • 79956317166 scopus 로고    scopus 로고
    • Defining the origins of Ras/p53-mediated squamous cell carcinoma
    • White AC, et al. Defining the origins of Ras/p53-mediated squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011;108(18):7425-7430.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.18 , pp. 7425-7430
    • White, A.C.1
  • 16
    • 78651467232 scopus 로고    scopus 로고
    • Basal cell carcinomas arise from hair follicle stem cells in Ptch1 (+/-) mice
    • Wang GY, Wang J, Mancianti ML, Epstein EH. Basal cell carcinomas arise from hair follicle stem cells in Ptch1 (+/-) mice. Cancer Cell. 2011;19(1):114-124.
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 114-124
    • Wang, G.Y.1    Wang, J.2    Mancianti, M.L.3    Epstein, E.H.4
  • 17
    • 79956351015 scopus 로고    scopus 로고
    • Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    • Chaffer CL, et al. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A. 2011;108(19):7950-7955.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.19 , pp. 7950-7955
    • Chaffer, C.L.1
  • 18
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133(4):704-715.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1
  • 19
    • 0344177195 scopus 로고    scopus 로고
    • Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34
    • Trempus CS, et al. Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol. 2003;120(4):501-511.
    • (2003) J Invest Dermatol , vol.120 , Issue.4 , pp. 501-511
    • Trempus, C.S.1
  • 20
    • 79960573076 scopus 로고    scopus 로고
    • Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-beta and integrin/focal adhesion kinase (FAK) signaling
    • Schober M, Fuchs E. Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-beta and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A. 2011;108(26):10544-10549.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.26 , pp. 10544-10549
    • Schober, M.1    Fuchs, E.2
  • 21
    • 4644306516 scopus 로고    scopus 로고
    • A distinct "side population" of cells with high drug efflux capacity in human tumor cells
    • Hirschmann-Jax C, et al. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. Proc Natl Acad Sci U S A. 2004;101(39):14228-14233.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.39 , pp. 14228-14233
    • Hirschmann-Jax, C.1
  • 22
    • 33748364556 scopus 로고    scopus 로고
    • Side population in adult murine epidermis exhibits phenotypic and functional characteristics of keratinocyte stem cells
    • Redvers RP, Li A, Kaur P. Side population in adult murine epidermis exhibits phenotypic and functional characteristics of keratinocyte stem cells. Proc Natl Acad Sci U S A. 2006;103(35):13168-13173.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.35 , pp. 13168-13173
    • Redvers, R.P.1    Li, A.2    Kaur, P.3
  • 23
    • 0036163391 scopus 로고    scopus 로고
    • Somatic epidermal stem cells can produce multiple cell lineages during development
    • Liang L, Bickenbach JR. Somatic epidermal stem cells can produce multiple cell lineages during development. Stem Cells. 2002;20(1):21-31.
    • (2002) Stem Cells , vol.20 , Issue.1 , pp. 21-31
    • Liang, L.1    Bickenbach, J.R.2
  • 24
    • 77955372945 scopus 로고    scopus 로고
    • Characterization of side populations in HNSCC: Highly invasive, chemoresistant and abnormal Wnt signaling
    • Song J, Chang I, Chen Z, Kang M, Wang CY. Characterization of side populations in HNSCC: highly invasive, chemoresistant and abnormal Wnt signaling. PLoS One. 2010;5(7):e11456.
    • (2010) PLoS One , vol.5 , Issue.7
    • Song, J.1    Chang, I.2    Chen, Z.3    Kang, M.4    Wang, C.Y.5
  • 25
    • 33646537475 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta type II receptor promotes metastatic headand-neck squamous cell carcinoma
    • Lu SL, et al. Loss of transforming growth factor-beta type II receptor promotes metastatic headand-neck squamous cell carcinoma. Genes Dev. 2006;20(10):1331-1342.
    • (2006) Genes Dev , vol.20 , Issue.10 , pp. 1331-1342
    • Lu, S.L.1
  • 26
    • 48749122568 scopus 로고    scopus 로고
    • Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
    • Hoot KE, et al. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest. 2008;118(8):2722-2732.
    • (2008) J Clin Invest , vol.118 , Issue.8 , pp. 2722-2732
    • Hoot, K.E.1
  • 27
    • 0034592978 scopus 로고    scopus 로고
    • Kinetics of UV light-induced cyclobutane pyrimidine dimers in human skin in vivo: An immunohistochemical analysis of both epidermis and dermis
    • Katiyar SK, Matsui MS, Mukhtar H. Kinetics of UV light-induced cyclobutane pyrimidine dimers in human skin in vivo: an immunohistochemical analysis of both epidermis and dermis. Photochem Photobiol. 2000;72(6):788-793.
    • (2000) Photochem Photobiol , vol.72 , Issue.6 , pp. 788-793
    • Katiyar, S.K.1    Matsui, M.S.2    Mukhtar, H.3
  • 28
    • 36148951013 scopus 로고    scopus 로고
    • H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase
    • Hanasoge S, Ljungman M. H2AX phosphorylation after UV irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase. Carcinogenesis. 2007;28(11):2298-2304.
    • (2007) Carcinogenesis , vol.28 , Issue.11 , pp. 2298-2304
    • Hanasoge, S.1    Ljungman, M.2
  • 29
    • 1842529559 scopus 로고    scopus 로고
    • Capturing and profiling adult hair follicle stem cells
    • Morris RJ, et al. Capturing and profiling adult hair follicle stem cells. Nat Biotechnol. 2004;22(4):411-417.
    • (2004) Nat Biotechnol , vol.22 , Issue.4 , pp. 411-417
    • Morris, R.J.1
  • 30
    • 33646537475 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta type II receptor promotes metastatic head-andneck squamous cell carcinoma
    • Lu SL, et al. Loss of transforming growth factor-beta type II receptor promotes metastatic head-andneck squamous cell carcinoma. Genes Dev. 2006;20(10):1331-1342.
    • (2006) Genes Dev , vol.20 , Issue.10 , pp. 1331-1342
    • Lu, S.L.1
  • 31
    • 78651380657 scopus 로고    scopus 로고
    • Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling
    • Mukhopadhyay A, Krishnaswami SR, Yu BD. Activated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling. J Invest Dermatol. 2011;131(2):311-319.
    • (2011) J Invest Dermatol , vol.131 , Issue.2 , pp. 311-319
    • Mukhopadhyay, A.1    Krishnaswami, S.R.2    Yu, B.D.3
  • 32
    • 25444473619 scopus 로고    scopus 로고
    • Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors
    • Yang L, et al. Targeted disruption of Smad4 in mouse epidermis results in failure of hair follicle cycling and formation of skin tumors. Cancer Res. 2005;65(19):8671-8678.
    • (2005) Cancer Res , vol.65 , Issue.19 , pp. 8671-8678
    • Yang, L.1
  • 33
    • 60749125436 scopus 로고    scopus 로고
    • Epidermal homeostasis: A balancing act of stem cells in the skin
    • Blanpain C, Fuchs E. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol. 2009;10(3):207-217.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.3 , pp. 207-217
    • Blanpain, C.1    Fuchs, E.2
  • 34
  • 35
    • 33846512398 scopus 로고    scopus 로고
    • Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
    • Prince ME, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A. 2007;104(3):973-978.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.3 , pp. 973-978
    • Prince, M.E.1
  • 36
    • 79960936439 scopus 로고    scopus 로고
    • Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative
    • Biddle A, et al. Cancer stem cells in squamous cell carcinoma switch between two distinct phenotypes that are preferentially migratory or proliferative. Cancer Res. 2011;71(15):5317-5326.
    • (2011) Cancer Res , vol.71 , Issue.15 , pp. 5317-5326
    • Biddle, A.1
  • 37
    • 43149084824 scopus 로고    scopus 로고
    • Isolation and shortterm culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice
    • Lichti U, Anders J, Yuspa SH. Isolation and shortterm culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice. Nat Protoc. 2008;3(5):799-810.
    • (2008) Nat Protoc , vol.3 , Issue.5 , pp. 799-810
    • Lichti, U.1    Anders, J.2    Yuspa, S.H.3
  • 38
    • 33644619021 scopus 로고    scopus 로고
    • Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
    • Yi R, et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006;38(3):356-362.
    • (2006) Nat Genet , vol.38 , Issue.3 , pp. 356-362
    • Yi, R.1
  • 39
    • 30144435485 scopus 로고    scopus 로고
    • The genetics of ATP-binding cassette transporters
    • Dean M. The genetics of ATP-binding cassette transporters. Methods Enzymol. 2005;400:409-429.
    • (2005) Methods Enzymol , vol.400 , pp. 409-429
    • Dean, M.1
  • 40
    • 70449338760 scopus 로고    scopus 로고
    • Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation
    • Bornstein S, et al. Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest. 2009;119(11):3408-3419.
    • (2009) J Clin Invest , vol.119 , Issue.11 , pp. 3408-3419
    • Bornstein, S.1
  • 41
    • 77649275464 scopus 로고    scopus 로고
    • MiR-9, a MYC/MYCN-activated micro-RNA, regulates E-cadherin and cancer metastasis
    • Ma L, et al. miR-9, a MYC/MYCN-activated micro-RNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol. 2010;12(3):247-256.
    • (2010) Nat Cell Biol , vol.12 , Issue.3 , pp. 247-256
    • Ma, L.1
  • 42
    • 80053450990 scopus 로고    scopus 로고
    • Aberrant hypermethylation of miR-9 genes in gastric cancer
    • Tsai KW, et al. Aberrant hypermethylation of miR-9 genes in gastric cancer. Epigenetics. 2011;6(10):1189-1197.
    • (2011) Epigenetics , vol.6 , Issue.10 , pp. 1189-1197
    • Tsai, K.W.1
  • 43
    • 84858239830 scopus 로고    scopus 로고
    • Genome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers
    • Heller G, et al. Genome-wide microRNA expression profiling identifies miR-9-3 and miR-193a as targets for DNA methylation in non-small cell lung cancers. Clin Cancer Res. 2012;18(6):1619-1629.
    • (2012) Clin Cancer Res , vol.18 , Issue.6 , pp. 1619-1629
    • Heller, G.1
  • 44
    • 84855868539 scopus 로고    scopus 로고
    • Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas
    • Minor J, et al. Methylation of microRNA-9 is a specific and sensitive biomarker for oral and oropharyngeal squamous cell carcinomas. Oral Oncol. 2012;48(1):73-78.
    • (2012) Oral Oncol , vol.48 , Issue.1 , pp. 73-78
    • Minor, J.1
  • 45
    • 77649312099 scopus 로고    scopus 로고
    • Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma
    • Wan HY, Guo LM, Liu T, Liu M, Li X, Tang H. Regulation of the transcription factor NF-kappaB1 by microRNA-9 in human gastric adenocarcinoma. Mol Cancer. 2010;9:16.
    • (2010) Mol Cancer , vol.9 , pp. 16
    • Wan, H.Y.1    Guo, L.M.2    Liu, T.3    Liu, M.4    Li, X.5    Tang, H.6
  • 46
    • 70349263692 scopus 로고    scopus 로고
    • MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-kappaB1
    • Guo LM, et al. MicroRNA-9 inhibits ovarian cancer cell growth through regulation of NF-kappaB1. FEBS J. 2009;276(19):5537-5546.
    • (2009) FEBS J , vol.276 , Issue.19 , pp. 5537-5546
    • Guo, L.M.1
  • 47
    • 84866093563 scopus 로고    scopus 로고
    • Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway
    • Zhuang G, et al. Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. EMBO J. 2012;31(17):3513-3523.
    • (2012) EMBO J , vol.31 , Issue.17 , pp. 3513-3523
    • Zhuang, G.1
  • 48
    • 84870261155 scopus 로고    scopus 로고
    • LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker
    • Chen D, et al. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 2012;18(10):1511-1517.
    • (2012) Nat Med , vol.18 , Issue.10 , pp. 1511-1517
    • Chen, D.1
  • 49
    • 84863790390 scopus 로고    scopus 로고
    • MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility
    • Zhu L, et al. MicroRNA-9 up-regulation is involved in colorectal cancer metastasis via promoting cell motility. Med Oncol. 2012;29(2):1037-1043.
    • (2012) Med Oncol , vol.29 , Issue.2 , pp. 1037-1043
    • Zhu, L.1
  • 50
    • 74949088546 scopus 로고    scopus 로고
    • Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck
    • Goto M, et al. Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck. Clin Cancer Res. 2010;16(1):65-76.
    • (2010) Clin Cancer Res , vol.16 , Issue.1 , pp. 65-76
    • Goto, M.1
  • 51
    • 27144542717 scopus 로고    scopus 로고
    • β-Catenin, Nf-κB and FAS protein expression are independent events in head and neck cancer: Study of their association with clinical parameters
    • Rodriguez-Pinilla M, et al. β-Catenin, Nf-κB and FAS protein expression are independent events in head and neck cancer: study of their association with clinical parameters. Cancer Lett. 2005;230(1):141-148.
    • (2005) Cancer Lett , vol.230 , Issue.1 , pp. 141-148
    • Rodriguez-Pinilla, M.1
  • 52
    • 77955078486 scopus 로고    scopus 로고
    • Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells
    • Chikazawa N, et al. Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Anticancer Res. 2010;30(6):2041-2048.
    • (2010) Anticancer Res , vol.30 , Issue.6 , pp. 2041-2048
    • Chikazawa, N.1
  • 53
    • 0034282519 scopus 로고    scopus 로고
    • Transactivation of the multidrug resistance 1 gene by T-cell factor 4/β-catenin complex in early colorectal carcinogenesis
    • Yamada T, et al. Transactivation of the multidrug resistance 1 gene by T-cell factor 4/β-catenin complex in early colorectal carcinogenesis. Cancer Res. 2000;60(17):4761-4766.
    • (2000) Cancer Res , vol.60 , Issue.17 , pp. 4761-4766
    • Yamada, T.1
  • 54
    • 0037309972 scopus 로고    scopus 로고
    • Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
    • Suzuki A, et al. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res. 2003;63(3):674-681.
    • (2003) Cancer Res , vol.63 , Issue.3 , pp. 674-681
    • Suzuki, A.1
  • 55
    • 28644451449 scopus 로고    scopus 로고
    • Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
    • Ito M, et al. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med. 2005;11(12):1351-1354.
    • (2005) Nat Med , vol.11 , Issue.12 , pp. 1351-1354
    • Ito, M.1
  • 57
    • 25144490181 scopus 로고    scopus 로고
    • Nonmelanoma skin cancer after liver transplantation. Study of risk factors
    • Herrero JI, et al. Nonmelanoma skin cancer after liver transplantation. Study of risk factors. Liver Transpl. 2005;11(9):1100-1106.
    • (2005) Liver Transpl , vol.11 , Issue.9 , pp. 1100-1106
    • Herrero, J.I.1
  • 59
    • 77958489647 scopus 로고    scopus 로고
    • Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma
    • Hildebrandt MA, et al. Hsa-miR-9 methylation status is associated with cancer development and metastatic recurrence in patients with clear cell renal cell carcinoma. Oncogene. 2010;29(42):5724-5728.
    • (2010) Oncogene , vol.29 , Issue.42 , pp. 5724-5728
    • Hildebrandt, M.A.1
  • 60
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature. 2007;449(7163):682-688.
    • (2007) Nature , vol.449 , Issue.7163 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 61
    • 33144490246 scopus 로고    scopus 로고
    • Links between a-catenin, NF-kB, and squamous cell carcinoma in skin
    • Kobielak A, Fuchs E. Links between a-catenin, NF-kB, and squamous cell carcinoma in skin. Proc Natl Acad Sci U S A. 2006;103(7):2322-2327.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.7 , pp. 2322-2327
    • Kobielak, A.1    Fuchs, E.2
  • 62
    • 79952298459 scopus 로고    scopus 로고
    • Yap1 acts downstream of alpha-catenin to control epidermal proliferation
    • Schlegelmilch K, et al. Yap1 acts downstream of alpha-catenin to control epidermal proliferation. Cell. 2011;144(5):782-795.
    • (2011) Cell , vol.144 , Issue.5 , pp. 782-795
    • Schlegelmilch, K.1
  • 64
    • 0034721099 scopus 로고    scopus 로고
    • Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFβRII
    • Go C, et al. Aberrant cell cycle progression contributes to the early-stage accelerated carcinogenesis in transgenic epidermis expressing the dominant negative TGFβRII. Oncogene. 2000;19(32):3623-3631.
    • (2000) Oncogene , vol.19 , Issue.32 , pp. 3623-3631
    • Go, C.1
  • 65
    • 2442548490 scopus 로고    scopus 로고
    • Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder
    • Li AG, Wang D, Feng XH, Wang XJ. Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder. EMBO J. 2004;23(8):1770-1781.
    • (2004) EMBO J , vol.23 , Issue.8 , pp. 1770-1781
    • Li, A.G.1    Wang, D.2    Feng, X.H.3    Wang, X.J.4
  • 66
    • 3042550759 scopus 로고    scopus 로고
    • Targeted disruption of TGF-β/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma
    • Lakos G, et al. Targeted disruption of TGF-β/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Am J Pathol. 2004;165(1):203-217
    • (2004) Am J Pathol , vol.165 , Issue.1 , pp. 203-217
    • Lakos, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.