Optimization and Pharmacological Validation of a Leukocyte Migration Assay in Zebrafish Larvae for the Rapid In Vivo Bioactivity Analysis of Anti-Inflammatory Secondary Metabolites

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Cordero Maldonado, María Lorena ^a,b,d   Siverio Mota, Dany ^a,c   Vicet Muro, Liliana ^a,c   Wilches Arizábala, Isabel María ^b   Esguerra, Camila V ^a   de Witte, Peter A M ^a   Crawford, Alexander D ^a,d  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSIDAD DE CUENCA   (Ecuador)

^c CENTRAL UNIVERSITY OF LAS VILLAS   (Cuba)

^d UNIVERSITY OF LUXEMBOURG   (Luxembourg)

Author keywords

[No Author keywords available]

Indexed keywords

AMANTADINE; ANTIINFLAMMATORY AGENT; ARNICA MONTANA EXTRACT; BACTERIUM LIPOPOLYSACCHARIDE; CALENDULA OFFICINALIS EXTRACT; CAPRARIA BIFLORA EXTRACT; CHAMAEMELUM NOBILE EXTRACT; DEXAMETHASONE; DICLOFENAC; DOXEPIN; HARPAGOPHYTUM PROCUMBENS EXTRACT; INDOMETACIN; MATRICARIA RECUTITA EXTRACT; MELAMINE; MYELOPEROXIDASE; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PLANT EXTRACT; PREDNISOLONE; SCHEFFLERA CHIMBUENSIS EXTRACT; SYZYGIUM MONTANUM EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARALIACEAE; ARNICA MONTANA; ARTICLE; CALENDULA OFFICINALIS; CAPRARIA BIFLORA; CHAMAEMELUM; CHAMAEMELUM NOBILE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG ISOLATION; DRUG SCREENING; EMBRYO; FERTILIZATION; HARPAGOPHYTUM; IMMUNOCYTOCHEMISTRY; INFLAMMATION; LARVA; LEUKOCYTE MIGRATION; LEUKOCYTE MIGRATION INHIBITION; MATRICARIA; NONHUMAN; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; SCHEFFLERA CHIMBUENSIS; SCROPHULARIACEAE; SYZYGIUM; SYZYGIUM MONTANUM; VALIDATION PROCESS; ZEBRA FISH;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL MIGRATION ASSAYS, LEUKOCYTE; INFLAMMATION; LARVA; LIPOPOLYSACCHARIDES; ZEBRAFISH;

EID: 84885044668     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075404     Document Type: Article

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