Structure-activity relationship for antiinflammatory effect of luteolin and its derived glycosides

Phytotherapy Research

Volumn 19, Issue 9, 2005, Pages 782-786

  Odontuya, G ^a,c   Hoult, J R S ^b   Houghton, P J ^b  

^a INSTITUTE OF CHEMISTRY AND CHEMICAL TECHNOLOGY   (Mongolia)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c Mongolian Institute Chemistry and Chemical Technology   (Mongolia)

Author keywords

Arachidonic acid inhibition; Hydrogen peroxide scavenging; Luteolin; Luteolin glycosides; Structure activity relationships

Indexed keywords

ARACHIDONIC ACID; CESIOSIDE; FLAVONOID GLYCOSIDE; HYDROGEN PEROXIDE; HYDROXYL GROUP; ISOORIENTIN; LEUKOTRIENE B4; LUTEOLIN; LUTEOLIN 7 GLUCOSIDE; STEREOLENSIN; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; FREE RADICAL SCAVENGERS; GENTIANA; GLYCOSIDES; HYDROGEN PEROXIDE; LEUKOCYTES; LUTEOLIN; MALE; PERITONEUM; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANTS, MEDICINAL; PYROLA; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 27644569566     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1723     Document Type: Article

References (21)

1. 13C NMR spectroscopy of flavonoids. Heterocycles 16: 2181-2236.
2. Arora A, Nair NG, Strasburg GM. 1998. Structure activity relationships for antioxidant activities of a series flavonoids in a liposomal system. Free Radic Biol Med 24: 1350-1363.
3. Bird TGC, Bruneu P, Crawley GC et al. 1991. (Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity. J Med Chem 34: 2176-2186.
4. Bors W, Saran M. 1987. Radical scavenging by flavonoid antioxidants. Free Radic Res Commun 2: 289-294.
5. Chang W-C, Hsu F-L. 1992. Inhibition of platelet activation and endothelial cell injury by polyphenolic compounds isolated from Lonicera japonica Thunb. Prostaglandins Leuko Essent Fatty Acids 45: 307-312.
6. Cos P, Calomme M, Sindambiwe JB et al. 2001. Cytotoxicity and lipid peroxidation-inhibiting activity flavonoids. Planta Med 67: 515-519.
7. Hammerschmidt R, Nuckles EM, Kuc J. 1982. Association of enhanced peroxidase-activity with induced systemic resistance of cucumber to Colletotrichum lagenarium. Physiol Plant Pathol 20: 73.
8. Harborne JB. 1994. The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer. In The Flavonoids, Advances in Research. Chapman and Hall: London, 619.
9. Hirano T, Higa S, Arimitsu J et al. 2004. Flavonoids such as luteolin, fisetin and apigenin are inhibitors of interleukin-4 and interleukin-13 production by activated human basophils. Int Arch Allergy Immunol 134: 135-140.
10. Ilarianov L, Rainova L, Nakov N. 1979. On anti-inflammatory and anti-ulcer activity of some flavonoides, isolated from the genus Genista L. Farmatsiia (Sofia) 29: 39.
11. Lewis DA. 1989. Anti-inflammatory drugs from plant and marine source. In Flavonoids. AAS, Birkhauser Verlag: Berlin, 137-167.
12. Mabry TJ, Markham KR, Thomas MB. 1975. The Systematic Identification of Flavonoids. Springer-Verlag: Berlin-Heidelberg-New York, 3-31.
13. Moroney MA, Alcaraz MJ, Forder RA, Carey F, Hoult JRS. 1988. Selectively of neutrophil 5-LOX and COX inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids. J Pharm Pharmacol 40: 787-792.
14. Odontuya G. 1997. The Chemical Study of γ-pyrones of Over Ground Parts of Halenia corniculata. PhD thesis. Ulaanbaatar, Mongolia, 98-108.
15. Odontuya G, Bayasgalan B, Hoult JRS, Houghton PJ. 2000. Luteolin-6-O-glucoside from Pyrola incarnata and its biological activity. J Pharm Pharmacol 52: 256.
16. Odontuya G, Hoult JRS, Houghton PJ. 2004. Phytochemical constituents of Gentiana azurea and Gentiana tenella and their biological activities (in press).
17. Odontuya G, Ouyn H, Wagner H. 1999. Chemical investigation of the ethyl acetate fraction of Gentiana tenella Rottb. In 2000 Years of Natural Products Research, Past, Present and Future. The Book of Abstracts. Amsterdam, Phytoconsult, Leiden, The Netherlands, 550.
18. Pietta PG. 2000. Flavonoids as antioxidants. J Nat Prod 63: 1035-1042.
19. Robak J, Gryglewski RJ. 1996. Bioactivity of flavonoids. Pol J Pharmacol 48: 555-564.
20. Rodriguez S, Wolfender JL, Odontuya G, Purev O, Hostettmann K. 1995. Xanthones secoiridoids and flavonoids from Halenia corniculata. Phytochemistry 40: 1265-1272.
21. Villar A, Gasco MA, Alcaraz MJ, Manez S, Cortes D. 1985. Hypolaetin-8-O-glucoside, an anti-inflammatory flavonoid from Sideritis mugronensis. Planta Med 51: 70.