Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models

Epilepsy and Behavior

Volumn 24, Issue 1, 2012, Pages 14-22

  Orellana Paucar, Adriana Monserrath ^a,b   Serruys, Ann Sophie K ^a   Afrikanova, Tatiana ^a   Maes, Jan ^a   De Borggraeve, Wim ^c   Alen, Jo ^c   León Tamariz, Fabián ^b   Wilches Arizábala, Isabel María ^b   Crawford, Alexander D ^a   de Witte, Peter A M ^a   Esguerra, Camila V ^a  

^a DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

^b UNIVERSIDAD DE CUENCA   (Ecuador)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

, Turmerone; Atlantone; Ar turmerone; Bisabolene sesquiterpenoids; Curcuma longa; Mouse PTZ model; Pentylenetetrazole; Turmeric; Turmeric oil; Zebrafish PTZ model

Indexed keywords

ALPHA ATLANTONE; ALPHA BETA TURMERONE; ANTICONVULSIVE AGENT; AR TURMERONE; CURCUMIN; METHANOL; PENTETRAZOLE; SESQUITERPENOID; TURMERIC; UNCLASSIFIED DRUG; VALPROIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BIOASSAY; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CURCUMA LONGA; EMBRYO; EPILEPTIC DISCHARGE; FRACTIONATION; IN VIVO STUDY; LARVA; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEIZURE; ZEBRA FISH;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTICONVULSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONVULSANTS; CURCUMA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; ELECTROENCEPHALOGRAPHY; GREEN FLUORESCENT PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MOVEMENT; PENTYLENETETRAZOLE; PHYTOTHERAPY; PLANT EXTRACTS; SEIZURES; VALPROIC ACID; ZEBRAFISH;

EID: 84860668697     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2012.02.020     Document Type: Article

References (46)

1. World Health Organization Atlas: epilepsy care in the world 2005, WHO Press, Geneva, Switzerland, 90 p.
2. Schmidt D. Drug treatment of epilepsy: options and limitations. Epilepsy Behav 2009, 15(1):56-65.
3. Arroyo S., de la Morena A. Life-threatening adverse events of antiepileptic drugs. Epilepsy Res 2001, 47(1-2):155-174.
4. Carpay J.A., Aldenkamp A.P., van Donselaar C.A. Complaints associated with the use of antiepileptic drugs: results from a community-based study. Seizure 2005, 14(3):198-206.
5. Arif H., Buchsbaum R., Weintraub D., Pierro J., Jr.S.R.R., Hirsch L.J. Patient-reported cognitive side effects of antiepileptic drugs: predictors and comparison of all commonly used antiepileptic drugs. Epilepsy Behav 2009, 14(1):202-209.
6. Meador K.J. Cognitive and memory effects of the new antiepileptic drugs. Epilepsy Res 2006, 68(1):63-67.
7. Schachter S.C. Botanicals and herbs: a traditional approach to treating epilepsy. Neurotherapeutics 2009, 6(2):415-420.
8. Nsour W., Lau C.B.-S., Wong I.C. Review on phytotherapy in epilepsy. Seizure 2000, 9(2):96-107.
9. Malawska B. New anticonvulsant agents. Curr Top Med Chem 2005, 5(1):69-85.
10. Willmore L.J., Losigamone, Willmar Schwabe Curr Opin Investig Drugs 2001, 2(12):1763-1766.
11. World Health Organization WHO monographs on selected medicinal plants 1999, WHO library cataloguing in publication data, Geneva, Switzerland, 289 p.
12. Jyoti A., Sethi P., Sharma D. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav 2009, 14(2):300-308.
13. Jithendra C., Murthy T.E., Upadyay L. Protective role of curcumin in maximal electroshock induced seizures, memory impairment and neurotransmitters in rat brain. JPCCR 2008, 2(1):35-39.
14. Sumanont Y., Murakami Y., Tohda M., Vajragupta O., Watanabe H., Matsumoto K. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Life Sci 2006, 78(16):1884-1891.
15. Mehla J., Reeta K.H., Gupta P., Gupta Y.K. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci 2010, 87(19-22):596-603.
16. Antony B., Merina B., Iyer V.S., Judy N., Lennertz K., Joyal S. A pilot cross-over study to evaluate human oral bioavailability of BCM-95®CG (Biocurcumax™), a novel bioenhanced preparation of curcumin. Indian J Pharm Sci. 2008, 70(4):445-449.
17. Sayyah M., Valizadeh J., Kamalinejad M. Anticonvulsant activity of the leaf essential oil of Laurus nobilis against pentylenetetrazole- and maximal electroshock-induced seizures. Phytomedicine 2002, 9(3):212-216.
18. Quintans-Júnior L.J., Souza T.T., Leite B.S., et al. Phytochemical screening and anticonvulsant activity of Cymbopogon winterianus Jowitt (Poaceae) leaf essential oil in rodents. Phytomedicine 2008, 15(8):619-624.
19. Dohare P., Varma S., Ray M. Curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury. Nitric Oxide 2008, 19(1):1-11.
20. Dohare P., Garg P., Sharma U., Jagannathan N.R., Ray M. Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC Complement Altern Med 2008, 8:55.
21. Rathore P., Dohare P., Varma S., Ray A., Sharma U., Jagannathan N.R. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem Res 2008, 33(9):1672-1682.
22. Crawford A.D., Esguerra C.V., de Witte P.A. Fishing for drugs from nature: zebrafish as a technology platform for natural product discovery. Planta Med 2008, 74(6):624-632.
23. Tan J.L., Zon Ll. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2011, 105:493-516.
24. Lockwood B., Bjerke S., Kobayashi K., Guo S. Acute effects of alcohol on larval zebrafish: a genetic system for large-scale screening. Pharmacol Biochem Behav 2004, 77(3):647-654.
25. Zon L., Peterson R. In vivo drug discovery in the zebrafish. Nat Rev 2005, 4(1):35-44.
26. Baraban S.C., Taylor M.R., Castro P.A., Baier H. Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 2005, 131(3):759-768.
27. Berghmans S., Hunt J., Roach A., Goldsmith P. Zebrafish offer the potential for a primary screen to identify a wide variety of potential anticonvulsants. Epilepsy Res 2007, 75(1):18-28.
28. Winter M.J., Redfern W.S., Hayfield A.J., Owen S.F., Valentin J.-P., Hutchinson T.H. Validation of a larval zebrafish locomotor assay for assessing the seizure liability of early-stage development drugs. J Pharmacol Toxicol Methods 2008, 57(3):176-187.
29. Mandhane S.N., Aavula K., Rajamannar T. Timed pentylenetetrazol infusion test: a comparative analysis with s.c. PTZ and MES models of anticonvulsant screening in mice. Seizure 2007, 16(7):636-644.
30. Sills G.J., Butler E., Thompson G.G., Brodie M.J. Pharmacodynamic interaction studies with topiramate in the pentylenetetrazol and maximal electroshock seizure models. Seizure 2004, 13(5):287-295.
31. Jackson B., Snowdon D. Atlas of microscopy of medicinal plants, culinary herbs and spices 1990, 257 p. Belhaven Press, London, U.K.
32. Westerfield M. The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio) 2000, University of Oregon, Eugene, Oregon. 4th ed.
33. He X.-G., Lin L.-Z., Lian L.-Z., Lindenmaier M. Liquid chromatography-electrospray mass spectrometric analysis of curcuminoids and sesquiterpenoids in turmeric (Curcuma longa). J Chromatogr A 1998, 818(1):127-132.
34. Giardina W.J., Gasior M. Acute seizure tests in epilepsy research: electroshock- and chemical-induced convulsions in the mouse. Current protocols in pharmacology 2009, 27-30. Wiley & Sons, Hoboken, NJ, USA. S.J. Enna, M. Williams, J.F. Barret, J.W. Ferkany, T. Kenakin, R.D. Porsolt (Eds.).
35. Scallier A., Massie A., Loyens E., et al. vGLUT2 heterozygous mice show more susceptibility to clonic seizures induced by pentylenetetrazol. Neurochem Int 2009, 55(1-3):41-44.
36. Kamal A., Shaheer Malik M., Azeeza S., Bajee S., Shaik A.A. Total synthesis of (R)- and (S)-turmerone and (7S,9R)-bisacumol by an efficient chemoenzymatic approach. Tetrahedron Asymmetr 2009, 20(11):1267-1271.
37. Uehara S.-I., Yasuda I., Takeya K., Itokawa H. New bisabolane sesquiterpenoids from the rhizomes of Curcuma xanthorrhiza (Zingiberaceae). Chem Pharm Bull 1989, 37(1):237-240.
38. Friesen R.W., Blouin M. Preparation of γ,δ-unsaturated β-ketophosphonates from tertiary α-allenic alcohols. The synthesis of (+/-)-(E)-α-atlantone. J Org Chem 1996, 61:7202-7206.
39. Bharal N., Sahaya K., Jain S., Mediratta P.K., Sharma K.K. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother Res 2008, 22(12):1660-1664.
40. Ribeiro M.C.P., de Ãvila D.S., Schneider C.Y.M., et al. alpha-Tocopherol protects against pentylenetetrazol- and methylmalonate-induced convulsions. Epilepsy Res 2005, 66(1-3):185-194.
41. Lores Arnaiz S., Travacio M., Llesuy S., Rodríguez de Lores Arnaiz G. Regional vulnerability to oxidative stress in a model of experimental epilepsy. Neurochem Res 1998, 23:1477-1483.
42. Willmore L.J. Antiepileptic drugs and neuroprotection: current status and future roles. Epilepsy Behav 2005, 7(Suppl. 3):S25-S28.
43. Löscher W., Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011, 52(4):657-678.
44. Villegas I., Sánchez-Fidalgo S., Alarcón de la Lastra C. New mechanisms and therapeutic potential of curcumin for colorectal cancer. Mol Nutr Food Res 2008, 52:1040-1061.
45. Joshi J., Ghaisas S., Vaidya A., et al. Early human safety study of turmeric oil (Curcuma longa oil) administered orally in healthy volunteers. J Assoc Physicians India 2003, 51:1055-1060.
46. Balaji S., Chempakam B. Toxicity prediction of compounds from turmeric (Curcuma longa L). Food Chem Toxicol 2010, 48(10):2951-2959.