Devil's claw (Harpagophytum procumbens): An anti-inflammatory herb with therapeutic potential

Phytochemistry Reviews

Volumn 4, Issue 1, 2005, Pages 47-53

  McGregor, Gerard ^a,b   Fiebich, Bernd ^c,d   Wartenberg, Andrea ^b   Brien, Sarah ^e   Lewith, George ^e   Wegener, Tankred ^f  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b Pascoe Pharmaceutical Preparations GmbH   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d VIVACELL BIOTECHNOLOGY GMBH   (Germany)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^f Consulting Herbal Medicinal Products ^*  (Germany)

Author keywords

Analgesic; Anti inflammatory; Devil's Claw; Harpagophytum procumbens; Osteoarthritis

Indexed keywords

2 CYCLOPENTYL 2 [4 (2 QUINOLINYLMETHOXY)PHENYL]ACETIC ACID; 8 ACETYLHARPAGIDE; 8 PARA COUMAROYL HARPAGIDE; ACETYLSALICYLIC ACID; AUCUBIN; HARPAGIDE; HARPAGOGENIN; HARPAGOPHYTUM EXTRACT; HARPAGOPHYTUM PROCUMBENS EXTRACT; HARPAGOSIDE; HERBACEOUS AGENT; IBUPROFEN; INDOMETACIN; IRIDOID; PHENYLBUTAZONE; PLANT MEDICINAL PRODUCT; PROCUMBIDE; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; CONFERENCE PAPER; DISEASE MODEL; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; HARPAGOPHYTUM; HARPAGOPHYTUM PROCUMBENS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATORY DISEASE; LOW BACK PAIN; MEDICINAL PLANT; MOLECULE; MUSCULOSKELETAL SYSTEM; NONHUMAN; OSTEOARTHRITIS; PAW EDEMA; PRIORITY JOURNAL; SOUTH AFRICA; WRITHING TEST;

HARPAGOPHYTUM PROCUMBENS;

EID: 23944465136     PISSN: 15687767     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11101-004-2374-8     Document Type: Conference Paper

References (27)

1. B Baghdikian MC Lanhers J Fleurentin E Ollivier C Maillard G Balansard F Mortier 1997 An analytical study, anti-inflammatory and analgesic effects of Harpagophytum procumbens and Harpagophytum zeyheri Planta Med 63 171 176
2. PB Benito AM Diaz Lanza AM Silvan en J de Santos Galindez 2000 Effects of some Iridoids from Plant Origin on Arachidonic Acid Metabolism in Cellular Systems Planta Med 66 324 328
3. BGA CEO (1989) Monographie Harpagophyti radix (Südafrikanische Teufelskrallenwurzel), BGA.
4. S Chrubasik C Conradt A Black 2003 The quality of clinical trials with Harpagophytum procumbens Phytomedicine 10 613 623
5. J Eich M Schmidt G Betti 1998 HPLC Analysis of Iridoid Compounds of Harpagophytum taxa: quality control of pharmaceutical drug material Pharm Pharmacol Lett 8 75 78
6. O Eichler C Koch 1970 Antiphlogistic, analgesic and spasmolytic effect of harpagoside, a glycoside from the root of Harpagophytum procumbens DC. Arzneimittelforschung 20 107 109
7. A Erdos R Fontaine H Friehe R Durand T Poppinghaus 1978 Contribution to the pharmacology and toxicology of different extracts as well as the harpagosid from Harpagophytum procumbens DC (author's transl) Planta Med 34 97 108
8. E Ernst S Chrubasik 2000 Phyto-anti-inflammatories. A systematic review of randomized, placebo-controlled, double-blind trials Rheum. Dis. Clin. North Am 26 13 27 vii
9. ESCOP 1996 Monographs of the Medicinal Use of Plant Drugs. Harpagophyti radix-Devil's claw European Scientific Cooperative on Phytotherapy Exeter, UK
10. ESCOP 2003 Monographs of the Medicinal Use of Plant Drugs. Harpagophyti radix-Devil's Claw European Scientific Cooperative on Phytotherapy Exeter, UK
11. Feistel, B & Gaedcke F (2000) Analytische Identifizierung von Radix Harpagophyti procumbentis und zeyheri Zeitschrift für Phytotherapie 21: 246-251.
12. BL Fiebich M Heinrich KO Hiller N Kammerer 2001 Inhibition of TNF-alpha synthesis in LPS-stimulated primary human monocytes by Harpagophytum extract SteiHap 69. Phytomedicine 8 28 30
13. RE Guzman MG Evans S Bove B Morenko K Kilgore 2003 Mono-iodoacetate- induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis Toxicol. Pathol 31 619 624
14. Jadot G. & Lecomte A (1992) Activé anti-inflammatoire d'Harpagophytum Procumbens D.C. Lyon Méditerranée médical médecine du sud-est.
15. MC Lanhers J Fleurentin F Mortier A Vinche C Younos 1992 Anti-inflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens Planta Med 58 117 123
16. D Loew J Mollerfeld A Schrodter S Puttkammer M Kaszkin 2001 Investigations on the pharmacokinetic properties of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo Clin. Pharmacol. Ther 69 356 364
17. DW McLeod P Revell BV Robinson 1979 Investigations of Harpagophytum procumbens (Devil's Claw) in the treatment of experimental inflammation and arthritis in the rat [proceedings] Br. J. Pharmacol 66 140P 141P
18. Morgenstern E & Pollex S (2000) Antiphlogistische und analgetische Wirkung von Teufelskrallenextrakt LI174. Poster P18, Phytopharmakaforschung 2000, Bonn 27-28.11.2002 Abstractband: 92-93.
19. AM Reimold 2002 TNFalpha as therapeutic target: new drugs, more applications Curr. Drug Targets Inflamm. Allergy 1 377 392
20. R Soulimani C Younos F Mortier C Derrieu 1994 The role of stomachal digestion on the pharmacological activity of plant extracts, using as an example extracts of Harpagophytum procumbens Can. J. Physiol. Pharmacol 72 1532 1536
21. Tippler B (1996) PhD Thesis; Harpagophytum procumbens: Wirkung von Extrakten auf die Eicosanoidbiosynthese in Ionophor A23187-stimuliertem menschlichem Vollblut. Department of Pharmakology & Toxikology, University of Bochum.
22. Vogel HG (2002) Drug Discovery and Evaluation, Pharmacological Assays, 2nd ed. Springer.
23. Wegener T (1998) Die Teufelskralle (Harpagophytum procumbens DC.) in der Therapie rheumatischer Erkrankungen. Zeitschrift für Phytotherapie 19. Jahrgang: 284-294.
24. T Wegener 2002 Degenerative diseases of the musculoskeletal system-overview of current clinical studies of Devil's Claw (Harpagophyti radix) Wien. Med. Wochenschr 152 389 392
25. Wegener T & Winterhoff H (2001) Zubereitungen aus der südafrikanischen Teufelskralle. Deutsche Apotheker Zeitung 141. Jahrgang: 5613-5621.
26. Wenzel P & Wegener T (1995) Teufelskralle-Ein pflanzliches Antirheumatikum. Deutsche Apotheker Zeitung 135.
27. LW Whitehouse M Znamirowska CJ Paul 1983 Devil's Claw (Harpagophytum procumbens): no evidence for anti-inflammatory activity in the treatment of arthritic disease Can. Med. Assoc. J 129 249 251