Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression

Journal of Clinical Investigation

Volumn 123, Issue 10, 2013, Pages 4242-4254

  Hochheiser, Katharina ^a   Heuser, Christoph ^a   Krause, Torsten A ^a   Teteris, Simon ^a   Ilias, Anissa ^b   Weisheit, Christina ^a   Hoss, Florian ^a   Tittel, André P ^a   Knolle, Percy A ^a,c   Panzer, Ulf ^d   Engel, Daniel R ^a   Tharaux, Pierre Louis ^b   Kurts, Christian ^a  

^a UNIVERSITY OF BONN   (Germany)

^b PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CX3CR1; FRACTALKINE; CHEMOKINE RECEPTOR; CX3CR1 PROTEIN, MOUSE; HLA ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL INFECTION; CELL COUNT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; DISEASE SEVERITY; GLOMERULONEPHRITIS; HELPER CELL; HISTOPATHOLOGY; IMMUNITY; INNATE IMMUNITY; INTESTINE; KIDNEY CELL; KIDNEY CORTEX; KIDNEY DENDRITIC CELL; KIDNEY MEDULLA; MOUSE; NEUTROPHIL; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PYELONEPHRITIS; STIMULATION; ANIMAL; ANTIGEN PRESENTATION; C57BL MOUSE; CELL CULTURE; FEMALE; GENETICS; IMMUNOLOGY; KIDNEY; MACROPHAGE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIGEN PRESENTATION; CELLS, CULTURED; DENDRITIC CELLS; DISEASE PROGRESSION; FEMALE; GLOMERULONEPHRITIS; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNITY, INNATE; KIDNEY; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PYELONEPHRITIS; RECEPTORS, CHEMOKINE; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84885044625     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI70143     Document Type: Article

References (53)

1. Wakim LM, Waithman J, van Rooijen N, Heath WR, Carbone FR. Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science. 2008;319(5860):198-202.
2. Heymann F, et al. Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest. 2009;119(5):1286-1297.
3. Riedel JH, et al. Immature renal dendritic cells recruit regulatory CXCR6 (+) invariant natural killer T cells to attenuate crescentic GN. J Am Soc Nephrol. 2012;23(12):1987-2000.
4. Tittel AP, Heuser C, Ohliger C, Knolle PA, Engel DR, Kurts C. Kidney dendritic cells induce innate immunity against bacterial pyelonephritis. J Am Soc Nephrol. 2011;22(8):1435-1441.
5. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327(5966):656-661.
6. Kruger T, et al. Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol. 2004;15(3):613-621.
7. Miller JC, et al. Deciphering the transcriptional network of the dendritic cell lineage. Nat Immunol. 2012;13(9):888-899.
8. Soos TJ, et al. CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int. 2006;70(3):591-596.
9. Dong X, Swaminathan S, Bachman LA, Croatt AJ, Nath KA, Griffin MD. Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int. 2007;71(7):619-628.
10. Dong X, Bachman LA, Miller MN, Nath KA, Griffin MD. Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction. Kidney Int. 2008;74(10):1294-1309.
11. Tipping PG, Holdsworth SR. T cells in crescentic glomerulonephritis. J Am Soc Nephrol. 2006;17(5):1253-1263.
12. Scholz J, et al. Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol. 2008;19(3):527-537.
13. Hochheiser K, et al. Kidney dendritic cells become pathogenic during crescentic glomerulonephritis with proteinuria. J Am Soc Nephrol. 2011;22(2):306-316.
14. Paust HJ, et al. Chemokines play a critical role in the cross-regulation of Th1 and Th17 immune responses in murine crescentic glomerulonephritis. Kidney Int. 2012;82(1):72-83.
15. Mora JR, et al. Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells. Nature. 2003;424(6944):88-93.
16. Campbell JJ, et al. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature. 1999;400(6746):776-780.
17. Panina-Bordignon P, et al. The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. J Clin Invest. 2001;107(11):1357-1364.
18. Reboldi A, et al. C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nat Immunol. 2009;10(5):514-523.
19. Villares R, et al. CCR6 regulates EAE pathogenesis by controlling regulatory CD4+ T-cell recruitment to target tissues. Eur J Immunol. 2009;39(6):1671-1681.
20. Jung S, et al. Analysis of fractalkine receptor CX (3) CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol. 2000;20(11):4106-4114.
21. Lee YS, et al. The fractalkine/CX3CR1 system regulates β cell function and insulin secretion. Cell. 2013;153(2):413-425.
22. Medina-Contreras O, et al. CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice. J Clin Invest. 2011;121(12):4787-4795.
23. Niess JH, et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005;307(5707):254-258.
24. Kim KW, et al. In vivo structure/function and expression analysis of the CX3C chemokine fractalkine. Blood. 2011;118(22):e156-e167.
25. Cockwell P, Calderwood JW, Brooks CJ, Chakravorty SJ, Savage CO. Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines. Nephrol Dial Transplant. 2002;17(5):734-744.
26. Segerer S, Hughes E, Hudkins KL, Mack M, Goodpaster T, Alpers CE. Expression of the fractalkine receptor (CX3CR1) in human kidney diseases. Kidney Int. 2002;62(2):488-495.
27. Hoffmann U, et al. Impact of chemokine receptor CX3CR1 in human renal allograft rejection. Transpl Immunol. 2010;23(4):204-208.
28. Haskell CA, et al. Targeted deletion of CX (3) CR1 reveals a role for fractalkine in cardiac allograft rejection. J Clin Invest. 2001;108(5):679-688.
29. Tacke F, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007;117(1):185-194.
30. Landsman L, et al. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood. 2009;113(4):963-972.
31. Karlmark KR, et al. The fractalkine receptor CX (3) CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes. Hepatology. 2010;52(5):1769-1782.
32. Combadiere C, et al. CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest. 2007;117(10):2920-2928.
33. Auffray C, et al. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med. 2009;206(3):595-606.
34. Li L, et al. The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int. 2008;74(12):1526-1537.
35. Furuichi K, Gao JL, Murphy PM. Chemokine receptor CX3CR1 regulates renal interstitial fibrosis after ischemia-reperfusion injury. Am J Pathol. 2006;169(2):372-387.
36. Shimizu K, et al. Fractalkine and its receptor, CX3CR1, promote hypertensive interstitial fibrosis in the kidney. Hypertens Res. 2011;34(6):747-752.
37. Feng L, et al. Prevention of crescentic glomerulonephritis by immunoneutralization of the fractalkine receptor CX3CR1 rapid communication. Kidney Int. 1999;56(2):612-620.
38. Plantinga M, et al. Conventional and monocyte-derived CD11b (+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Immunity. 2013;38(2):322-335.
39. Kurts C, Heymann F, Lukacs-Kornek V, Boor P, Floege J. Role of T cells and dendritic cells in glomerular immunopathology. Semin Immunopathol. 2007;29(4):317-335.
40. Lukacs-Kornek V, Burgdorf S, Diehl L, Specht S, Kornek M, Kurts C. The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol. 2008;180(2):706-715.
41. Delamarre L, Pack M, Chang H, Mellman I, Trombetta ES. Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate. Science. 2005;307(5715):1630-1634.
42. Dong X, Swaminathan S, Bachman LA, Croatt AJ, Nath KA, Griffin MD. Antigen presentation by dendritic cells in renal lymph nodes is linked to systemic and local injury to the kidney. Kidney Int. 2005;68(3):1096-1108.
43. Serbina NV, Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol. 2006;7(3):311-317.
44. Shortman K, Naik SH. Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol. 2007;7(1):19-30.
45. Liu K, et al. In vivo analysis of dendritic cell development and homeostasis. Science. 2009;324(5925):392-397.
46. Tittel AP, et al. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat Methods. 2012;9(4):385-390.
47. Schulz O, et al. Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions. J Exp Med. 2009;206(13):3101-3114.
48. Zigmond E, et al. Ly6C hi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity. 2012;37(6):1076-1090.
49. Bogunovic M, et al. Origin of the lamina propria dendritic cell network. Immunity. 2009;31(3):513-525.
50. Ginhoux F, et al. The origin and development of nonlymphoid tissue CD103+ DCs. J Exp Med. 2009;206(13):3115-3130.
51. Nelson PJ, Rees AJ, Griffin MD, Hughes J, Kurts C, Duffield J. The renal mononuclear phagocytic system. J Am Soc Nephrol. 2012;23(2):194-203.
52. Bollee G, et al. Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med. 2011;17(10):1242-1250.
53. Godaly G, Proudfoot AE, Offord RE, Svanborg C, Agace WW. Role of epithelial interleukin-8 (IL-8) and neutrophil IL-8 receptor A in Escherichia coli-induced transuroepithelial neutrophil migration. Infect Immun. 1997;65(8):3451-3456.