Kidney dendritic cells become pathogenic during crescentic glomerulonephritis with proteinuria

Journal of the American Society of Nephrology

Volumn 22, Issue 2, 2011, Pages 306-316

  Hochheiser, Katharina ^a   Engel, Daniel R ^a   Hammerich, Linda ^a,c   Heymann, Felix ^a,c   Knolle, Percy A ^a   Panzer, Ulf ^b   Kurts, Christian ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDUCIBLE COSTIMULATORY MOLECULE LIGAND; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23P40; INTERLEUKIN 6; LYMPHOCYTE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATTENUATION; CONTROLLED STUDY; CRESCENTIC GLOMERULONEPHRITIS; CYTOKINE PRODUCTION; DENDRITIC CELL; DISEASE COURSE; DISEASE EXACERBATION; GLOMERULONEPHRITIS; IMMUNE COMPLEX NEPHRITIS; KIDNEY CELL; KIDNEY DENDRITIC CELL; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEINURIA; TH1 CELL; TH17 CELL;

EID: 79551680089     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2010050548     Document Type: Article

References (47)

1. Kaissling B, Le Hir M: Characterization and distribution of interstitial cell types in the renal cortex of rats. Kidney Int 45: 709-720, 1994 (Pubitemid 24094482)
2. Kruger T, Benke D, Eitner F, Lang A, Wirtz M, Hamilton-Williams EE, Engel D, Giese B, Muller-Newen G, Floege J, Kurts C: Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. J Am Soc Nephrol 15: 613-621, 2004
3. Soos TJ, Sims TN, Barisoni L, Lin K, Littman DR, Dustin ML, Nelson PJ: CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. Kidney Int 70: 591-596, 2006
4. Woltman AM, de Fijter JW, Zuidwijk K, Vlug AG, Bajema IM, van der Kooij SW, van Ham V, van Kooten C: Quantification of dendritic cell subsets in human renal tissue under normal and pathological conditions. Kidney Int 71: 1001-1008, 2007 (Pubitemid 46741991)
5. Steinman RM, Bonifaz L, Fujii S, Liu K, Bonnyay D, Yamazaki S, Pack M, Hawiger D, Iyoda T, Inaba K, Nussenzweig MC: The innate functions of dendritic cells in peripheral lymphoid tissues. Adv Exp Med Biol 560: 83-97, 2005
6. Shortman K, Naik SH: Steady-state and inflammatory dendritic-cell development. Nat Rev Immunol 7: 19-30, 2007
7. Anders HJ, Banas B, Schlondorff D: Signaling danger: Toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 15: 854-867, 2004
8. Bretscher P, Cohn M: A theory of self-nonself discrimination. Science 169: 1042-1049, 1970
9. Curtsinger JM, Schmidt CS, Mondino A, Lins DC, Kedl RM, Jenkins MK, Mescher MF: Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. J Immunol 162: 3256-3262, 1999
10. Kurts C, Kosaka H, Carbone FR, Miller JF, Heath WR: Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8(+) T cells. J Exp Med 186: 239-245, 1997
11. Heymann F, Meyer-Schwesinger C, Hamilton-Williams EE, Hammerich L, Panzer U, Kaden S, Quaggin SE, Floege J, Grone HJ, Kurts C: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest 119: 1286-1297, 2009
12. Wakim LM, Waithman J, van Rooijen N, Heath WR, Carbone FR: Dendritic cell-induced memory T cell activation in nonlymphoid tissues. Science 319: 198-202, 2008
13. Dong X, Swaminathan S, Bachman LA, Croatt AJ, Nath KA, Griffin MD: Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int 71: 619-628, 2007
14. Dong X, Bachman LA, Miller MN, Nath KA, Griffin MD: Dendritic cells facilitate accumulation of IL-17 T cells in the kidney following acute renal obstruction. Kidney Int 74: 1294-1309, 2008
15. Iwata Y, Furuichi K, Sakai N, Yamauchi H, Shinozaki Y, Zhou H, Kurokawa Y, Toyama T, Kitajima S, Okumura T, Yamada S, Maruyama I, Matsushima K, Kaneko S, Wada T: Dendritic cells contribute to autoimmune kidney injury in MRL-Faslpr mice. J Rheumatol 36: 306-314, 2009
16. Kurts C, Heymann F, Lukacs-Kornek V, Boor P, Floege J: Role of T cells and dendritic cells in glomerular immunopathology. Semin Immunopathol 29: 317-335, 2007 (Pubitemid 350077267)
17. Segerer S, Heller F, Lindenmeyer MT, Schmid H, Cohen CD, Draganovici D, Mandelbaum J, Nelson PJ, Grone HJ, Grone EF, Figel AM, Nossner E, Schlondorff D: Compartment specific expression of dendritic cell markers in human glomerulonephritis. Kidney Int 74: 37-46, 2008
18. Hochheiser K, Tittel A, Kurts C: Kidney dendritic cells in acute and chronic renal disease. Int J Exp Pathol July 30, 2010 [Epub ahead of print]
19. Tadagavadi RK, Reeves WB: Renal dendritic cells ameliorate nephrotoxic acute kidney injury. J Am Soc Nephrol 21: 53-63, 2009
20. Rogers NM, Matthews TJ, Kausman JY, Kitching RA, Coates PT: Review article: Kidney dendritic cells: Their role in homeostasis, inflammation and transplantation. Nephrology (Carlton) 14: 625-635, 2009
21. Coates PT, Duncan FJ, Colvin BL, Wang Z, Zahorchak AF, Shufesky WJ, Morelli AE, Thomson AW: In vivo-mobilized kidney dendritic cells are functionally immature, subvert alloreactive T-cell responses, and prolong organ allograft survival. Transplantation 77: 1080-1089, 2004 (Pubitemid 38508927)
22. Scholz J, Lukacs-Kornek V, Engel D, Specht S, Kiss E, Eitner F, Floege J, Groene H, Kurts C: Kidney dendritic cells stimulate IL-10 production in nephrotoxic nephritis and attenuate disease. J Am Soc Nephrol 19: 57-637, 2008
23. Tipping PG, Holdsworth SR: T cells in crescentic glomerulonephritis. J Am Soc Nephrol 17: 1253-1263, 2006
24. Kitching AR, Tipping PG, Huang XR, Mutch DA, Holdsworth SR: Interleukin-4 and interleukin-10 attenuate established crescentic glomerulonephritis in mice. Kidney Int 52: 52-59, 1997
25. Wilson HM, Stewart KN, Brown PA, Anegon I, Chettibi S, Rees AJ, Kluth DC: Bone-marrow-derived macrophages genetically modified to produce IL-10 reduce injury in experimental glomerulonephritis. Molec Therap 6: 710-717, 2002
26. Odobasic D, Kitching AR, Semple TJ, Holdsworth SR: Inducible costimulatory molecule ligand is protective during the induction and effector phases of crescentic glomerulonephritis. J Am Soc Nephrol 17: 1044-1053, 2006
27. Paust HJ, Turner JE, Steinmetz OM, Peters A, Heymann F, Holscher C, Wolf G, Kurts C, Mittrucker HW, Stahl RA, Panzer U: The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis. J Am Soc Nephrol 20: 969-979, 2009
28. Steinmetz OM, Turner JE, Paust HJ, Linder M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, HW, M, Stahl RA, Panzer U: CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis. J Immunol 183: 4693-4704, 2009
29. Ooi JD, Phoon RK, Holdsworth SR, Kitching AR: IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen. J Am Soc Nephrol 20: 980-989, 2009
30. Kitching AR, Tipping PG, Holdsworth SR: IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. Eur J Immunol 29: 1-10, 1999
31. Timoshanko JR, Kitching AR, Holdsworth SR, Tipping PG: Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis. J Am Soc Nephrol 12: 464-471, 2001 (Pubitemid 32180015)
32. Timoshanko JR, Holdsworth SR, Kitching AR, Tipping PG: IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol 168: 4135-4141, 2002
33. Timoshanko JR, Sedgwick JD, Holdsworth SR, Tipping PG: Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis. J Am Soc Nephrol 14: 1785-1793, 2003
34. Lukacs-Kornek V, Burgdorf S, Diehl L, Specht S, Kornek M, Kurts C: The kidney-renal lymph node-system contributes to cross-tolerance against innocuous circulating antigen. J Immunol 180: 706-715, 2008
35. Ruth AJ, Kitching AR, Li M, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR: An IL-12-independent role for CD40-CD154 in mediating effector responses: Studies in cell-mediated glomerulonephritis and dermal delayed-type hypersensitivity. J Immunol 173: 136-144, 2004
36. Odobasic D, Kitching AR, Semple TJ, Timoshanko JR, Tipping PG, Holdsworth SR: Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis. J Am Soc Nephrol 16: 2012-2022, 2005
37. Jung S, Unutmaz D, Wong P, Sano G, De los SK, Sparwasser T, Wu S, Vuthoori S, Ko K, Zavala F, Pamer EG, Littman DR, Lang RA: In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17: 211-220, 2002
38. Kitching AR, Turner AL, Wilson GR, Semple T, Odobasic D, Timoshanko JR, O'Sullivan KM, Tipping PG, Takeda K, Akira S, Holdsworth SR: IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment. J Am Soc Nephrol 16: 2023-2033, 2005
39. Ishida H, Muchamuel T, Sakaguchi S, Andrade S, Menon S, Howard M: Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice. J Exp Med 179: 305-310, 1994 (Pubitemid 24012996)
40. Chadban SJ, Tesch GH, Lan HY, Atkins RC, Nikolic-Paterson DJ: Effect of interleukin-10 treatment on crescentic glomerulonephritis in rats. Kidney Int 51: 1809-1817, 1997
41. Geissmann F, Jung S, Littman DR: Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19: 71-82, 2003
42. Liu K, Waskow C, Liu X, Yao K, Hoh J, Nussenzweig M: Origin of dendritic cells in peripheral lymphoid organs of mice. Nat Immunol 8: 578-583, 2007
43. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K: Development of monocytes, macrophages, and dendritic cells. Science 327: 656-661, 2010
44. Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ, Merad M: Langerhans cells arise from monocytes in vivo. Nat Immunol 7: 265-273, 2006
45. Abbate M, Zoja C, Remuzzi G: How does proteinuria cause progressive renal damage? J Am Soc Nephrol 17: 2974-2984, 2006
46. Macconi D, Chiabrando C, Schiarea S, Aiello S, Cassis L, Gagliardini E, Noris M, Buelli S, Zoja C, Corna D, Mele C, Fanelli R, Remuzzi G, Benigni A: Proteasomal processing of albumin by renal dendritic cells generates antigenic peptides. J Am Soc Nephrol 20: 123-130, 2009
47. Assmann KJ, Tangelder MM, Lange WP, Schrijver G, Koene RA: Anti-GBM nephritis in the mouse: Severe proteinuria in the heterologous phase. Virchows Arch A Pathol Anat Histopathol 406: 285-299, 1985