Relative quantitative comparison between lipotoxicity and glucotoxicity affecting the PARP-NAD-SIRT1 pathway in hepatocytes

Cellular Physiology and Biochemistry

Volumn 32, Issue 3, 2013, Pages 719-727

  Pang, Jing ^a   Xi, Chao ^b   Jin, Junhua ^a   Han, Yiwen ^a   Zhang, Tie Mei ^a  

^a BEIJING HOSPITAL   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

Author keywords

Cytotoxicity; Free fatty acids; Hepatocytes; Hyperglycemia; Poly (ADP) ribose polymerase

Indexed keywords

ADENYLATE KINASE; GLUCOSE; INSULIN; INSULIN RECEPTOR; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLEIC ACID; SIRTUIN 1;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; ENZYME PHOSPHORYLATION; GLUCOTOXICITY; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; LIPOTOXICITY; LIVER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

CELL SURVIVAL; GENE EXPRESSION; GLUCOSE; HEP G2 CELLS; HUMANS; HYDROCARBONS, FLUORINATED; INSULIN; NAD; OLEIC ACID; ORPHAN NUCLEAR RECEPTORS; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; RECEPTOR, INSULIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIRTUIN 1; SULFONAMIDES;

EID: 84885008052     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000354474     Document Type: Article

References (17)

1. Robertson RP, Harmon J, Tran PO, Poitout V: Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004; 1:S119-124.
2. Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, Hashizume K: Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells. J Biol Chem 2000;275:20880-20886.
3. Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J: Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Mol Endocrinol 2004;18:2024-2034.
4. Pang J, Gong H, Xi C, Fan W, Dai Y, Zhang TM: Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes. J Cell Biochem 2011;112:299-306.
5. de Murcia JM, Niedergang C, Trucco C, Ricoul M, Dutrillaux B, Mark M, Oliver FJ, Masson M, Dierich A, LeMeur M, Walztinger C, Chambon P, de Murcia G: Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc Natl Acad Sci USA 1997;94:7303-7307.
6. Yi LZ, He J, Liang YZ, Yuan DL, Chau FT: Plasma fatty acid metabolic profiling and biomarkers of type 2 diabetes mellitus based on GC/MS and PLS-LDA. FEBS Lett 2006;580:6837-6845.
7. Azevedo-Martins AK, Monteiro AP, Lima CL, Lenzen S, Curi R: Fatty acid-induced toxicity and neutral lipid accumulation in insulin-producing RINm5F cells. Toxicol In Vitro 2006;20:1106-1113.
8. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P: Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005;434:113-118.
9. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De Oliveira R, Leid M, McBurney MW, Guarente L: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 2004;429:771-776.
10. Sun C, Zhang F, Ge X, Yan T, Chen X, Shi X, Zhai Q: SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metabolism 2007;6:307-319.
11. Groop LC, Bonadonna RC, Del Prato S, Ratheiser K, Zyck K, Ferrannini E, DeFronzo RA: Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance. J Clin Invest 1989;84:205-213.
12. Groop L, Saloranta C, Shank M, Bonadonna RC, Ferrannini E, DeFronzo RA: The role of free fatty acid metabolism in the pathogenesis of insulin resistance in obesity and noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1991;72:96-107.
13. Jucker BM, Rennings AJM, Cline GW, Shulman GI: 13C and 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat. J Biol Chem 1997;272:10464-10473.
14. Peet DJ, Turley SD, Ma W, Janowski BA, Lobaccaro JM, Hammer RE, Mangelsdorf DJ: Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR a. Cell 1998;93:693-704.
15. Tobin KA, Steineger HH, Alberti S, Spydevold O, Auwerx J, Gustafsson JA, Nebb HI: Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Mol Endocrinol 2000;14:741-752.
16. Liu L, Li Y, Guan C, Li K, Wang C, Feng R, Sun C: Free fatty acid metabolic profile and biomarkers of isolated post-challenge diabetes and type 2 diabetes mellitus based on GC-MS and multivariate statistical analysis. J Chromatography B 2010;878:2817-2825.
17. Ricchi M, Odoardi MR, Carulli L, Anzivino C, Ballestri S, Pinetti A, Fantoni LI, Marra F, Bertolotti M, Banni S, Lonardo A, Carulli N, Loria P: Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol Hepatol 2009;24:830-840.