Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes

Journal of Cellular Biochemistry

Volumn 112, Issue 1, 2011, Pages 299-306

  Pang, Jing ^a,b   Gong, Huan ^b   Xi, Chao ^c   Fan, Wei ^a,b   Dai, Yang ^a,b   Zhang, Tie Mei ^b  

^a GRADUATE SCHOOL OF PEKING UNION MEDICAL COLLEGE   (China)

^b BEIJING HOSPITAL   (China)

^c BEIJING NORMAL UNIVERSITY   (China)

Author keywords

AMPK; Hyperglycemia; Insulin sensitivity; NAD; PARP1; SIRT1

Indexed keywords

GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SMALL INTERFERING RNA;

ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; GLUCOSE METABOLISM; GLUCOSE TOXICITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INSULIN SENSITIVITY; LIVER CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RNA INTERFERENCE;

AMP-ACTIVATED PROTEIN KINASES; GLUCOSE; HEP G2 CELLS; HEPATOCYTES; HUMANS; PHENANTHRENES; POLY(ADP-RIBOSE) POLYMERASES; REACTIVE OXYGEN SPECIES; SIRTUIN 1; TRANSFECTION;

EID: 78651314568     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22919     Document Type: Article

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