Reciprocal interferences of TNF-α and Wnt1/β-catenin signaling axes shift bone marrow-derived stem cells towards osteoblast lineage after ethanol exposure

Cellular Physiology and Biochemistry

Volumn 32, Issue 3, 2013, Pages 755-765

  Chen, Yueping ^a,b   Chen, Liang ^b   Yin, Qingshui ^c   Gao, Hui ^b   Dong, Panfeng ^b   Zhang, Xiaoyun ^b   Kang, Jie ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b RUIKANG HOSPITAL AFFILIATED TO GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

^c GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

Adipogenisis; Bone marrow stem cells (BMSC); Ethanol; Multipotential mesenchymal stem cells (MSC); Osteoblast; Osteogenesis; siRNA; TNF ; Wnt1; catenin

Indexed keywords

ALCOHOL; ALKALINE PHOSPHATASE; BETA CATENIN; COLLAGEN TYPE 1; OSTEOCALCIN; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA; WNT1 PROTEIN; TRANSCRIPTION FACTOR AP 2;

ADIPOCYTE; ADULT; ARTICLE; BONE DEVELOPMENT; CALCIFICATION; CELL LINEAGE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSOL; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; OSTEOBLAST; OSTEOCYTE; PRIORITY JOURNAL; UPREGULATION; WNT SIGNALING PATHWAY; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL LEVEL; CELL NUCLEUS; PROTEIN CONTENT; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADIPOGENESIS; BETA CATENIN; BONE MARROW CELLS; CELL LINEAGE; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; ETHANOL; FATTY ACID-BINDING PROTEINS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; OSTEOPONTIN; PPAR GAMMA; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; WNT1 PROTEIN;

EID: 84885004730     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000354477     Document Type: Article

References (42)

1. Fancy SP, Harrington EP, Yuen TJ, Silbereis JC, Zhao C, Baranzini SE, Bruce CC, Otero JJ, Huang EJ, Nusse R, Franklin RJ, Rowitch DH: Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci 2011;14: 1009-1016.
2. Ao A, Hao J, Hopkins CR, Hong CC: DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. PLoS One 2012;7:e41627.
3. Russo I, Caracciolo L, Tweedie D, Choi SH, Greig NH, Barlati S, Bosetti F: 3,6'-Dithiothalidomide, a new TNF-α synthesis inhibitor, attenuates the effect of Aβ1-42 intracerebroventricular injection on hippocampal neurogenesis and memory deficit. J Neurochem 2012;122: 1181-1192.
4. D'Amato RJ, Loughnan MS, Flynn E, Folkman J: Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 1994;91: 4082-4085.
5. Włodarski KH: Haematopoietic and osteogenic bone marrow stem cells. Ortop Traumatol Rehabil 2011;13: 439-447.
6. Pignolo RJ, Shore EM: Circulating osteogenic precursor cells. Crit Rev Eukaryot Gene Expr 2010;20: 171-180.
7. Wu JY, Scadden DT, Kronenberg HM: Role of the osteoblast lineage in the bone marrow hematopoietic niches. J Bone Miner Res 2009;24: 759-764.
8. Heino TJ, Hentunen TA: Differentiation of osteoblasts and osteocytes from mesenchymal stem cells. Curr Stem Cell Res Ther 2008;3: 131-145.
9. Derubeis AR, Cancedda R: Bone marrow stromal cells (BMSCs) in bone engineering: limitations and recent advances. Ann Biomed Eng 2004;32: 160-165.
10. Mareddy S, Broadbent J, Crawford R, Xiao Y: Proteomic profiling of distinct clonal populations of bone marrow mesenchymal stem cells. J Cell Biochem 2009;106: 776-786.
11. Potier E, Noailly J, Ito K: Directing bone marrow-derived stromal cell function with mechanics. J Biomech 2010;43: 807-817.
12. Yang X, Matsuda K, Bialek P, Jacquot S, Masuoka HC, Schinke T, Li L, Brancorsini S, Sassone-Corsi P, Townes TM, Hanauer A, Karsenty G: ATF4 is a substrate of RSK2 and essential regulator of osteoblast biology: Implication for Coffin-Lowry Syndrome. Cell 2004;117: 387-398.
13. Wek RC, Jiang HY, Anthony TG: Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 2006;34: 7-11.
14. Vattem KM, Wek RC: Reinitation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proc Natl Acad Sci USA 2004;101: 11269-11274.
15. Gimble JM, Nuttall ME: The relationship between adipose tissue and bone metabolism. Clin Biochem 2012;45: 874-879.
16. Peng S, Zhang G, He Y, Wang X, Leung P, Leung K, Qin L: Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone 2009;45: 534-544.
17. Liu TM, Martina M, Hutmacher DW, Hui JH, Lee EH, Lim B: Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 2007;25: 750-760.
18. Huang Q, Zhang H, Pei FX, Chen ZY, Wang GL, Shen B, Yang J, Zhou ZK, Kong QQ: Use of small interfering ribonucleic acids to inhibit the adipogenic effect of alcohol on human bone marrow-derived mesenchymal cells. Int Orthop 2010;34: 1059-1068.
19. Hamamura K, Yokota H: Stress to endoplasmic reticulum of mouse osteoblasts induces apoptosis and transcriptional activation for bone remodeling. FEBS Lett 2007;581: 1769-1774.
20. Nusse R, Varmus HE: Wnt genes. Cell 1992;69: 1073-1087.
21. Laine CM, Joeng KS, Campeau PM, Kiviranta R, Tarkkonen K, Grover M, Lu JT, Pekkinen M, Wessman M, Heino TJ, Nieminen-Pihala V, Aronen M, Laine T, Kröger H, Cole WG, Lehesjoki AE, Nevarez L, Krakow D, Curry CJ, Cohn DH, Gibbs RA, Lee BH, Mäkitie O: WNT1 mutations in early-onset osteoporosis and osteogenesis imperfecta. N Engl J Med 2013;368: 1809-1816.
22. Liu G, Vijayakumar S, Grumolato L, Arroyave R, Qiao H, Akiri G, Aaronson SA: Canonical Wnts function as potent regulators of osteogenesis by human mesenchymal stem cells. J Cell Biol 2009;185: 67-75.
23. Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, Zhao W, Li C, Kharode Y, Sauter L, Babij P, Brown EL, Hill AA, Akhter MP, Johnson ML, Recker RR, Komm BS, Bex FJ: Wnt/beta-catenin signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 2006;281: 31720-31728.
24. Day TF, Guo X, Garrett-Beal L, Yang Y: Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 2005;8: 739-750.
25. Hill TP, Spater D, Taketo MM, Birchmeier W, Hartmann C: Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes. Dev Cell 2005;8: 727-738.
26. Bennett CN, Ouyang H, Ma YL, Zeng Q, Gerin I, Sousa KM, Lane TF, Krishnan V, Hankenson KD, MacDougald OA: Wnt10b increases postnatal bone formation by enhancing osteoblast differentiation. J Bone Miner Res 2007;22: 1924-1932.
27. Morvan F, Boulukos K, Clément-Lacroix P, Roman Roman S, Suc-Royer I, Vayssière B, Ammann P, Martin P, Pinho S, Pognonec P, Mollat P, Niehrs C, Baron R, Rawadi G: Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res 2006;21: 934-945.
28. Chen JR, Lazarenko OP, Shankar K, Blackburn ML, Badger TM, Ronis MJ: A role for ethanol-induced oxidative stress in controlling lineage commitment of mesenchymal stromal cellsthrough inhibition of Wnt/beta-catenin signaling. J Bone Miner Res 2010;25: 1117-1127.
29. Wahl EC, Aronson J, Liu L, Liu Z, Perrien DS, Skinner RA, Badger TM, Ronis MJ, Lumpkin CK Jr: Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: role of the TNF signaling axis. Toxicol Appl Pharmacol 2007;220: 302-310.
30. Wang Y, Li Y, Mao K, Li J, Cui Q, Wang GJ: Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res 2003;410: 213-224.
31. Cui Q, Wang Y, Saleh KJ, Wang GJ, Balian G: Alcohol-induced adipogenesis in a cloned bone-marrow stem cell. J Bone Joint Surg Am 2006;88 Suppl 3: 148-154.
32. Rosa ML, Beloti MM, Prando N, Queiroz RH, de Oliveira PT, Rosa AL: Chronic ethanol intake inhibits in vitro osteogenesis induced by osteoblasts differentiated from stem cells. J Appl Toxicol 2008;28: 205-211.
33. Diamond T, Stiel D, Lunzer M, Wilkinson M, Posen S: Ethanol reduces bone formation and may cause osteoporosis. Am J Med 1989;86: 282-288.
34. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science 1999;284: 143-147.
35. Klein RF: Alcohol-induced bone disease: impact of ethanol on osteoblast proliferation. Alcohol Clin Exp Res 1997;21: 392-399.
36. Sato N, Meijer L, Skaltsounis L, Greengard P, Brivanlou AH: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 2004;10: 55-63.
37. Fragoso MA, Patel AK, Nakamura RE, Yi H, Surapaneni K, Hackam AS. The Wnt/β-catenin pathway cross-talks with STAT3 signaling to regulate survival of retinal pigment epithelium cells. PLoS One 2012;7:e46892.
38. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G: Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997;89: 747-754.
39. McKee MD, Nanci A: Osteopontin: an interfacial extracellular matrix protein in mineralized tissues. Connect Tissue Res 1996;35: 197-205.
40. Aubin JE, Liu F: The osteoblast lineage; in Bilezikian JP, Raisz LG, Rodan GA (eds): Principles of Bone Biology. San Diego, Academic Press; 1996, pp 51-67.
41. Verras M, Papandreou I, Lim AL, Denko NC: Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress. Mol Cell Biol 2008;28: 7212-7224.
42. Wei L, Sun C, Lei M, Li G, Yi L, Luo F, Li Y, Ding L, Liu Z, Li S, Xu P: Activation of Wnt/β-catenin pathway by exogenous Wnt1 protects SH-SY5Y cells against 6-hydroxydopamine toxicity. J Mol Neurosci 2013;49: 105-115.